Health Services Research & Development

03/05/2018 | Press release | Distributed by Public on 03/05/2018 13:31

Evidence Brief: Hyperbaric Oxygen Therapy (HBOT) for Traumatic Brain Injury and/or Post-traumatic Stress Disorder

Investigators: Kim Peterson, MS; Donald Bourne, MPH; Johanna Anderson, MPH; Erin Boundy, MS; Mark Helfand, MD, MS, MPH

Evidence-based Synthesis Program (ESP) Center, Portland VA Health Care System Portland, OR

Washington (DC): Department of Veterans Affairs; February 2018.

Download PDF:Brief, Supplemental Materials


The ESP Coordinating Center (ESP CC) is responding to a request from the Center for Compassionate Innovation (CCI) for an evidence brief on the use of hyperbaric oxygen therapy (HBOT) for the treatment of traumatic brain injury (TBI), posttraumatic stress disorder (PTSD), or their cooccurrence. Findings from this evidence brief will be used to inform considerations of clinical use of HBOT in Veterans with TBI and/or PTSD.

Key Questions

KQ1: What are the potential benefits of HBOT for the treatment of TBI and/or PTSD?

KQ2: What are the potential risks of using HBOT for the treatment of TBI and/or PTSD?

KQ3: Do the benefits or risks of HBOT differ per patient characteristics (eg, patient demographics, comorbidities, disease severity)?

KQ4: Do the benefits or risks of HBOT differ per treatment protocol (eg, number of sessions, amount of pressure, inpatient vs outpatient treatment)?