01/21/2020 | Press release | Distributed by Public on 01/21/2020 08:48
However, the study did not show improvements in other markers of cardiovascular and metabolic health, a finding that indicates vitamin D supplementation alone may not be the cure-all for improving the heart health of children at highest risk for diabetes and heart disease.
The children were split into three groups and given pills that appeared identical, but contained different quantities of vitamin D, which is measured in international units, or IUs. One group received a 600 IU tablet daily, which is the current recommended daily dietary allowance. The other two groups received either a 1,000 IU or 2,000 IU tablet daily, still well below the 4,000 IU daily maximum considered safe for children in this age range. During the trial, neither the participants, nor their doctors, knew which dose each child was receiving.
Blood tests showed that the higher the daily dose of vitamin D, the greater the improvement in the participants' blood concentration of vitamin D. By the conclusion of the trial, none of the groups was considered vitamin D deficient.
After six months, the children receiving the daily 2,000 IU vitamin D supplement had a reduced fasting blood glucose level and improved insulin sensitivity - both of which reduce susceptibility to diabetes and improve cardiovascular health. After six months, the children receiving 1,000 IUs of vitamin D daily had lower blood pressure. High blood pressure is bad because it increases risk of heart attack, stroke and kidney disease.
The study did not reveal any significant changes in measures of the health of the membrane that lines the blood vessels or arterial stiffness - both of which are strong indicators of heart health and were the primary measures that the researchers were seeking to influence with vitamin D supplementation.
'There are many reasons we might not have seen changes in endothelial function or arterial stiffness,' said Rajakumar, who also is a pediatrician at UPMC Children's Hospital. 'Maybe vitamin D simply doesn't influence these, or perhaps we didn't reach and maintain a level of vitamin D to cause an effect. It could also be that our trial didn't run long enough. However, treatment of vitamin D deficiency with these higher daily doses can have a positive impact on cardiometabolic health of children, without negative side effects.'