Shiseido MIRAI Technology Institute’s Researcher, Satoshi Horiba Won the Best Presentation Award at 22nd Annual Meeting of the Japanese Society of Anti-Aging Medicine

■ IL-34 Downregulation‒Associated M1/M2 Macrophage Imbalance Is Related to Inflammaging in Sun-Exposed Human Skin
It is important to elucidate the mechanism of chronic inflammation in order to improve the quality of life (QOL) in an aging society. Particularly, "inflammaging", in which chronic inflammation accelerates aging, has been shown to cause various diseases, and the elucidation of its mechanism is urgently required. Although it has long been suggested that chronic inflammation occurs in sun-exposed skin, resulting in developing wrinkles and sagging, its detailed mechanism has not been clarified. In this study, we became the first to reveal the possibility that an imbalance of macrophages, a type of immune cell, induces inflammaging in sun-exposed human skin, and that a decrease in IL-34(*2) produced in the epidermis may be involved in the mechanism of developing inflammaging.
*2 A protein secreted by cells and a type of interleukin involved in intercellular interactions. It was identified in 2008, and is known to be highly expressed in skin, especially as an important factor for the maintenance of Langerhans cells.