04/07/2021 | Press release | Distributed by Public on 04/07/2021 00:36
BioInvent receives IND approval for Phase I/IIa trial of anti-TNFR2 antibody BI-1808
The Phase I/IIa study will evaluate the safety, tolerability, and potential signs of efficacy of BI-1808 as a single agent, and in combination with the anti-PD-1 therapy Keytruda® in patients with ovarian cancer, non-small cell lung cancer and CTCL. It is planned to be carried out in the U.S., Denmark, Hungary, the United Kingdom and Russia and is already enrolling patients.
The anti-TNFR2 antibody BI-1808 is a first-in-class drug candidate and is part of BioInvent's tumor-associated regulatory T cells (Treg)-targeting program. This has emerged from the F.I.R.S.T™ platform technology that simultaneously identifies new targets and high-quality antibodies, generating promising new drug candidates to target the tumor microenvironment (TME). TNFR2 is particularly upregulated on Tregs of the TME and has been shown to be important for tumor expansion and survival, representing a new and promising target for cancer immunotherapies.
About BioInventThe Company generates revenues from research collaborations and license agreements with multiple top-tier pharmaceutical companies, as well as from producing antibodies for third parties in the Company's fully integrated manufacturing unit. More information is available at www.bioinvent.com.
For further information, please contact:
Cecilia Hofvander Mary-Ann Chang, LifeSci Advisors
Senior Director Investor Relations +44 7483 284853
+46 (0)46 286 85 50 [email protected]
[email protected]
The information was submitted for publication at 08:30 a.m. CEST on April 7, 2021.