Anglia Ruskin University

08/19/2019 | Press release | Distributed by Public on 08/19/2019 02:31

Age-related illness risk for people living with HIV

Published: 19 August 2019 at 09:18

Study finds increased incidence of heart disease, COPD and bone fractures

The first large-scale review into the health outcomes of people living with HIV has found that this group has an increased risk of contracting specific diseases and illnesses, some of which are more commonly associated with ageing.

The umbrella review, led by academics from Anglia Ruskin University (ARU) in Cambridge and the Medical University of Vienna, combined data from 20 separate observational studies and examined 55 different illnesses.

Published this week in the journal Clinical Infectious Diseases, the study found that people living with HIV have a significantly elevated risk of Chronic Obstructive Pulmonary Disease (COPD) and coughs, heart disease, pregnancy mortality and sepsis, anemia, and bone fractures.

Although the number of people contracting HIV is declining, approximately 1.8 million people are infected every year and HIV remains one of the world's major health issues.

In recent years, people living with HIV have benefited from improved access to antiretroviral treatment. However, increased life expectancy and a lower immunity has meant higher levels of comorbidity, with people living with HIV also more likely to suffer from other illnesses.

The greater prevalence of age-associated diseases may be explained by the persistent immunodeficiency and inflammation connected with HIV. There are also adverse effects associated with antiretroviral treatment.

Previous studies have also suggested that people living with HIV in developed countries, as a population, often exhibit greater risk factors associated with non-AIDS related illnesses, such as smoking, drug use and alcohol use.

Senior author Dr Lee Smith, Reader in Physical Activity and Public Health at Anglia Ruskin University (ARU), said: