American College of Cardiology Foundation

11/17/2019 | Press release | Distributed by Public on 11/17/2019 16:10

Study Looks at Risk Score Performance in Type 2 MI

In patients with type 2 myocardial infarction (MI), the use of current risk scores 'display poor to modest discrimination in identifying mortality and MACE,' according to a study published Nov. 11 in the Journal of the American College of Cardiology, and presented during AHA 2019 in Philadelphia, PA.

Sean Murphy, MBBCh, BAO, et al., looked at 359 patients at Massachusetts General Hospital with type 2 MI using the 2018 Forth Universal Definition of MI. GRACE, TIMI and TARRACO risk scores were calculated for all patients and risk score performance was assessed.

Results showed the mean GRACE, TIMI and TARRACO scores were 140±31, 3.7±1.4, and 4.9±2.2, respectively. In addition, GRACE 'modestly predicted' in-hospital, 30-day, and 90-day mortality, while TIMI and TARRACO did not predict all-cause mortality.

Both TIMI and GRACE 'modestly and similarly' predicted cardiovascular death, whereas TARRACO did not predict cardiovascular death. Finally, TIMI 'modestly predicted' 30-day MACE but not in-hospital or 90-day MACE. Meanwhile, GRACE and TARRACO did not predict MACE.

The authors conclude that moving forward, 'new metrics are needed for risk stratification in order to facilitate the development of therapies for this challenging diagnosis.'

Keywords:AHA19, AHA Annual Scientific Sessions, Myocardial Infarction, Diabetes Mellitus, Type 2

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