01/15/2020 | News release | Distributed by Public on 01/15/2020 06:32
Leader in clinical research for Alzheimer's, Parkinson's and other misfolded protein diseases joins advisory board of global leaders in neurodegenerative diseases
TORONTO, Ontario and CAMBRIDGE, Mass.-January 15, 2020-ProMIS Neurosciences, Inc. (TSX: PMN) (OTCQB: ARFXF), a biotechnology company focused on the discovery and development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases, has welcomed José Luis Molinuevo, MD, PhD, to its scientific advisory board (SAB). Dr. Molinuevo is an internationally recognized neurologist, researcher, professor, principal investigator and clinician focused on Alzheimer's disease (AD) and related disorders, including other protein misfolding diseases such as Parkinson's.
Dr. Molinuevo is the Scientific Director of the Alzheimer Prevention Program at the BarcelonaBeta Brain Research Center (BBRC)in Barcelona, Spain, which focuses on Alzheimer's disease prevention from a clinical, cognitive, genetic, and biomarker perspective. He is an associate professor at the University Pompeu Fabra, member of several professional societies governing neurodegenerative diseases, principal investigator of multiple clinical trials and research studies on AD and author of more than 330 international scientific papers, several books and over 20 book chapters on neurodegenerative diseases. He received his MD from the University of Valencia and his PhD in neurology from the University of Barcelona.
'Dr. Molinuevo's research contributions to Alzheimer's and other protein misfolding diseases has strengthened our understanding of toxicity in the brain,' said Eugene Williams, Executive Chairman of ProMIS Neurosciences. 'He's a beacon among the community of researchers who believe the revised amyloid hypothesis - which zeroes in on the toxic oligomer of beta amyloid as the driver of brain cell death - will drive a next generation of beta-amyloid targeting therapies that offer precision selectivity for this toxic target following anticipated regulatory approval for the first-generation candidate, aducanumab. We're honored to work with such an accomplished, committed SAB, and extend our warmest welcome to Dr. Molinuevo.'
'This is an incredibly exciting time in Alzheimer's disease research,' said Dr. José Luis Molinuevo, MD, PhD. 'In this decade, we'll see the first disease modifying therapy for AD followed by better, second generation therapies, validating decades of data showing the toxic role of misfolded amyloid beta in the brain. Protein misfolding is a root cause of several other neurodegenerative diseases, and ProMIS is uniquely able to target only the toxic oligomer of these misfolded species, a previously elusive accomplishment. I'm honored to join such an esteemed group of leaders in neurodegenerative disease as we embark on a decade that I feel will be marked by several disease-modifying therapies for not only Alzheimer's but a host of other neurodegenerative diseases.'
ProMIS' SAB members are highly published and cited contributors to current scientific understanding of Alzheimer's, Parkinson's, ALS, protein misfolding diseases in general and other neurodegenerative diseases. Current members include:
About misfolded proteins and the toxic oligomer
Misfolded proteins play a key pathogenic role in the development of neurodegenerative diseases. Misfolded proteins aggregate, forming small clumps (oligomers) that are both toxic to neurons and responsible for the 'prion-like' propagation (spreading) of the neurotoxicity, ultimately leading to clinical symptoms of disease. Using its novel drug discovery engine, ProMIS can uniquely and selectively target the toxic oligomer, filling a critical gap for drug developers: traditional approaches to developing antibodies are unable to isolate and target the toxic oligomer with adequate precision. The company's Alzheimer's disease program includes two antibody candidates that offer targeting of the toxic oligomers of tau and amyloid beta, currently one of the most promising areas of therapy development in Alzheimer's disease. ProMIS' Parkinson's disease program includes several potential antibody therapeutic candidates aimed at selectively targeting toxic oligomers of the protein α-synuclein, considered a root cause of Parkinson's disease. ProMIS has also identified antibody candidates that selectively target toxic oligomers of the protein TDP-43, considered a root cause of ALS.
About ProMIS Neurosciences
ProMIS Neurosciences, Inc. is a development stage biotechnology company focused on discovering and developing antibody therapeutics selectively targeting toxic oligomers implicated in the development and progression of neurodegenerative diseases, in particular Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). The Company's proprietary target discovery platform is based on the use of two complementary thermodynamic, computational discovery engines -ProMIS and Collective Coordinates- to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this unique precision approach, the Company is developing novel antibody therapeutics for AD, ALS and PD. ProMIS is headquartered in Toronto, Ontario, with offices in Cambridge, Massachusetts. ProMIS is listed on the Toronto Stock Exchange under the symbol PMN, and on the OTCQB Venture Market under the symbol ARFXF.
For media inquiries, please contact:
Tel. 617 921-0808
For Investor Relations please contact:
Alpine Equity Advisors
Nicholas Rigopulos, President
Tel. 617 901-0785
The TSX has not reviewed and does not accept responsibility for the adequacy or accuracy of this release. This information release contains certain forward-looking information. Such information involves known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to be materially different from those implied by statements herein, and therefore these statements should not be read as guarantees of future performance or results. All forward-looking statements are based on the Company's current beliefs as well as assumptions made by and information currently available to it as well as other factors. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. Due to risks and uncertainties, including the risks and uncertainties identified by the Company in its public securities filings, actual events may differ materially from current expectations. The Company disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.