Explanation of Responses:
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1. The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.
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2. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $72.35 to $73.34, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.
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3. Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.
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4. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $73.35 to $74.20, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.
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5. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $74.64 to $75.50, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.
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6. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $75.69 to $76.64, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.
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7. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $76.69 to $77.015, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.
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8. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $69.315 to $70.31, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.
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9. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $70.315 to $71.31, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.
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10. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $71.315 to $72.305, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.
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11. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $72.32 to $72.55, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.
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12. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $68.92 to $69.875, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.
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13. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $69.92 to $70.69, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.
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14. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $71.09 to $72.08, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.
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15. This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $72.10 to $72.91, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.
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16. David E. Shaw is President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the sole member of D. E. Shaw Technology Development, LLC.
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Remarks:
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