Cincinnati Children's Hospital Medical Center

01/24/2020 | Press release | Distributed by Public on 01/24/2020 13:56

High Air Pollution Exposure in One-Year-Olds Linked to Structural Brain Changes at Age 12

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'If early life TRAP exposure irreversibly harms brain development, structural consequences could persist regardless of the time point for a subsequent examination,' says Beckwith.

The researchers on the study, which is published online in PLOS One, used magnetic resonance imaging to obtain anatomical brain images from 147 12 year olds. These children are a subset of the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS), which recruited volunteers prior to the age of six months to examine early childhood exposure to TRAP and health outcomes.

The volunteers in the CCAAPS had either high or low levels of TRAP exposure during their first year of life. The researchers estimated exposure using an air sampling network of 27 sites in the Cincinnati area, and 24/7 sampling was conducted simultaneously at four or five sites over different seasons. Participating children and their caregivers completed clinic visits at ages 1, 2, 3, 4, 7 and 12.

Previous studies of TRAP suggest that it contributes to neurodegenerative diseases and neurodevelopmental disorders. This work supports that TRAP changes brain structure early in life.

Senior author of the study is Kim Cecil, PhD, a scientist at the Cincinnati Children's Imaging Research Center.

Contact Information

Jim Feuer
513-636-4656