Results

U.S. Department of Health & Human Services

07/07/2020 | Press release | Distributed by Public on 07/07/2020 15:25

Infographic: Tracking MIS-C: Multi-System Inflammatory Syndrome in U.S. Children

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Tracking MIS-C: Multi-System Inflammatory Syndrome in U.S. Children

186 MIS-C Cases, 26 states

March 15-May 20, 2020

Epidemiology of MIS-C

Hospital-reported MIS-C Cases by State:

  • 16 states reported 1-6 cases
  • 4 states reported 7-14 cases
  • 1 state reported 15-21 cases
  • 4 states reported 22-29 cases

MIS-C and COVID-19 Activity

[Chart showing percentage of positive COVID-19 tests and number of MIS-C cases from March 15-May 20]

By leveraging a national influenza surveillance network of pediatric ICUs[i], CDC and partners conducted targeted surveillance for MIS-C from March 15 through May 20, 2020, identifying 186 MIS-C cases in 26 states.

Gender

Age

  • 7%, <1
  • 28%, 1-4
  • 25%, 5-9
  • 24%, 10-14
  • 16%, 15-20

Percentage of U.S. Children with MIS-C, by race and ethnicity*

  • 31% Hispanic or Latino
  • 25% Black, non-Hispanic
  • 19% white, non-Hispanic
  • 5% other, non-Hispanic
  • 22%, unknown

*race categories were non-exclusive

Cases Met 5 Criteria

  1. Hospitalized patients < 21 years
  2. Fever ≥ 24 hours
  3. Laboratory evidence of inflammation
  4. ≥ 2 organs involved
  5. Evidence of SARS-CoV-2[ii] by RT-PCR[iii], antibody test, or exposure to a person with COVID-19 in the prior month

Impact on the Cardiovascular System

Percentage of Patients with Impact on the Heart

  • Any CVI[iv] (80%)
  • Elevated troponin (50%)
  • B-type natriuretic peptide (BNP) > 400 (73%)
  • Echocardiography performed (91%)
  • Pericarditis or pericardial effusion (26%)
  • Ejection fraction of < 30% (5%)
  • Ejection fraction of 30 to < 55% (33%)
  • Ejection fraction ≥ 55% (62%)
  • Z-score of LAD