Alexandria Real Estate Equities Inc.

07/25/2022 | Press release | Distributed by Public on 07/25/2022 14:10

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022 - Form 8-K



(1)Represents annual rental revenue in effect as of June 30, 2022.
(2)As of June 30, 2022. Represents the percentage of our annual rental revenue generated by our top 20 tenants that are also investment-grade or publicly traded large cap tenants. Refer to "Annual rental revenue" and Investment-grade or publicly traded large cap tenants" in the "Definitions and reconciliations" of our Supplemental Information for additional details.
(3)Represents annual rental revenue currently generated from space that is targeted for a future change in use. The weighted-average remaining term of these leases is 4.2 years.
(4)Our other tenants, aggregating 4.0% of our annual rental revenue, comprise 3.0% of annual rental revenue from technology, professional services, finance, telecommunications, and construction/real estate companies and only 1.0% from retail-related tenants.

As of June 30, 2022.
(1)We may also commence additional projects in this time frame, subject to market conditions.


(1)Represents dividend declared on June 30, 2022, annualized.





(1)As of June 30, 2022. Refer to "Key credit metrics" of our Supplemental Information for additional details.
(2)As of June 30, 2022.
(3)As of June 30, 2022. Refer to "Annual rental revenue" and "Investment-grade or publicly traded large cap tenants" in the "Definitions and reconciliations" of our Supplemental Information for additional details.

(1)A credit rating is not a recommendation to buy, sell, or hold securities and may be subject to revision or withdrawal at any time. Top 10% ranking represents credit rating levels from Moody's Investors Service and S&P Global Ratings for publicly traded U.S. REITs, from Bloomberg Professional Services as of June 30, 2022.


(1)A credit rating is not a recommendation to buy, sell, or hold securities and may be subject to revision or withdrawal at any time. Top 10% ranking represents credit rating levels from Moody's Investors Service and S&P Global Ratings for publicly traded U.S. REITs, from Bloomberg Professional Services as of June 30, 2022.
(2)As of June 30, 2022. Refer to "Key credit metrics" of our Supplemental Information for additional details.
(3)Quarter annualized.
(4)As of June 30, 2022.

(1)Source: Barron's, "10 Real Estate Companies That Are Both Greener and More Profitable," February 19, 2022.

Environmental data for 2021 reflected in the chart above received independent limited assurance from DNV Business Assurance USA, Inc.
(1)2025 environmental goal for Alexandria's cumulative progress relative to a 2015 baseline on a like-for-like basis for buildings in operation that the company directly manages.
(2)2025 environmental goal for buildings in operation that Alexandria indirectly and directly manages. In alignment with industry best practice, the company reports waste diversion annually; the 2025 goal is to
achieve a waste diversion rate of at least 45% by 2025.
(3)Progress toward 2025 goal.

Table of Contents
June 30, 2022
EARNINGS PRESS RELEASE Page Page
Second Quarter Ended June 30, 2022 Financial and Operating Results
1
8
4
9
5
10
Guidance
6
11
SUPPLEMENTAL INFORMATION Page Page
14
External Growth / Investments in Real Estate
15
33
16
New Class A Development and Redevelopment Properties:
18
35
19
38
20
43
Internal Growth
47
21
48
22
Balance Sheet Management
23
50
24
51
25
52
26
Definitions and Reconciliations
27
55
This document includes "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Please refer to page 8 of this Earnings Press Release and Supplemental Information for further information.

This document is not an offer to sell or a solicitation to buy securities of Alexandria Real Estate Equities, Inc. Any offers to sell or solicitations to buy our securities shall be made only by means of a prospectus approved for that purpose. Unless otherwise indicated, the "Company," "Alexandria," "ARE," "we," "us," and "our" refer to Alexandria Real Estate Equities, Inc. and our consolidated subsidiaries.
Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2022
xviii

Alexandria Real Estate Equities, Inc. Reports:
2Q22 and 1H22 Net Income per Share - Diluted of $1.67 and $0.74, respectively; and
2Q22 and 1H22 FFO per Share - Diluted, As Adjusted, of $2.10 and $4.15, respectively

PASADENA, Calif. - July 25, 2022 - Alexandria Real Estate Equities, Inc. (NYSE:ARE) announced financial and operating results for the second quarter ended June 30, 2022.
Key highlights
Operating results 2Q22 2Q21 1H22 1H21
Total revenues:
In millions $ 643.8 $ 509.6 $ 1,258.8 $ 989.5
Growth 26.3 % 27.2 %
Net income attributable to Alexandria's common stockholders - diluted
In millions $ 269.3 $ 380.6 $ 118.5 $ 388.5
Per share $ 1.67 $ 2.61 $ 0.74 $ 2.74
Funds from operations attributable to Alexandria's common stockholders - diluted, as adjusted
In millions $ 338.8 $ 282.3 $ 663.4 $ 545.2
Per share $ 2.10 $ 1.93 $ 4.15 $ 3.84
Ringing of the New York Stock Exchange Opening Bell to celebrate our 25th anniversary
In celebration of our 25th anniversary as a publicly traded company, we recently rang The Opening Bell® at the New York Stock Exchange to mark this momentous milestone. From our initial public offering on May 27, 1997 through May 27, 2022, we have generated a total stockholder return ("TSR") of 1,902%, assuming reinvestment of dividends, substantially outperforming the MSCI U.S. REIT Index TSR of 803% and the FTSE Nareit Equity Office Index TSR of 457%.
A REIT industry-leading high-quality roster of over 1,000 tenants with high-quality revenues and cash flows, strong margins, and operational excellence
Percentage of total annual rental revenue in effect from investment-grade or publicly traded large cap tenants 50 %
Sustained strength in tenant collections:
Tenant receivables as of June 30, 2022
$ 7.1 million
July tenant rent and receivables collected as of July 25, 2022
99.9 %
Occupancy of operating properties in North America 94.6 %
Occupancy of operating properties in North America (excluding vacancy at recently acquired properties) 98.4 %
(1)
Operating margin 70 %
Adjusted EBITDA margin 70 %
Weighted-average remaining lease term:
All tenants 7.1 years
Top 20 tenants 10.2 years
(1)Excludes 1.6 million RSF, or 3.8%, of vacancy at recently acquired properties representing lease-up opportunities that are expected to provide incremental annual rental revenue. Refer to "Occupancy" in our Supplemental Information.
(1)

Record rental rate increases and continued historic high leasing volume
•For 2Q22, rental rate increases of 45.4% and 33.9% (cash basis) represent the second- highest and the highest quarterly increases in Company history, respectively.
•During 2Q22, we executed 2,279,758 RSF of leasing activity, representing the third-highest quarter of leasing volume in Company history; 87% of this leasing activity was generated from a roster of over 1,000 tenants and other relationships.
2Q22 1H22
Total leasing activity - RSF 2,279,758 4,743,196
Leasing of development and redevelopment space - RSF 916,436 2,356,132
Lease renewals and re-leasing of space:
RSF (included in total leasing activity above) 1,087,082 1,951,159
Rental rate increases 45.4% 39.0%
Rental rate increases (cash basis) 33.9% 25.2%
Continued strong net operating income and internal growth
•Net operating income (cash basis) of $1.6 billion for 2Q22 annualized, up $315.5 million, or 24.3%, compared to 2Q21 annualized.
•97% of our leases contain contractual annual rent escalations approximating 3%.
•Same property net operating income increases:
•7.5% and 10.2% (cash basis) for 2Q22 over 2Q21, representing the second- and third-highest increases in the past 10 years, respectively.
•7.7% and 8.6% (cash basis) for 1H22 over 1H21.
Strong valuations for partial interest sale and dispositions
During 2Q22, we completed a partial interest sale and dispositions aggregating $548.7 million, including:
•Sale of a 70% interest in 300 Third Street in our Cambridge/Inner Suburbs submarket for a sales price of $166.5 million, or $1,802 per RSF, representing capitalization rates of 4.6% and 4.3% (cash basis).
•Sale of 12 properties in our Route 128 and Route 495 suburban submarkets of Greater Boston for an aggregate sales price of $334.4 million, or $542 per RSF, representing a capitalization rate (cash basis) of 5.1%.
Strong and flexible balance sheet with significant liquidity as of June 30, 2022
•Investment-grade credit ratings ranked in the top 10% among all publicly traded U.S. REITs.
•Net debt and preferred stock to Adjusted EBITDA of 5.5x and fixed-charge coverage ratio of 5.1x for 2Q22 annualized.
•Total debt and preferred stock to gross assets of 28%.
•98.3% of our debt has a fixed rate.
•13.6 years weighted-average remaining term of debt.
•$5.5 billion of liquidity.
Second Quarter Ended June 30, 2022 Financial and Operating Results (continued)
June 30, 2022
Continued high demand for Alexandria's brand drives visibility for future growth aggregating $665 million of incremental annual rental revenue
Our highly leased value-creation pipeline of current and key near-term projects that are under construction or that will commence construction in the next six quarters is expected to generate greater than $665 million of incremental annual rental revenue, primarily commencing from 3Q22 through 2Q25.
•7.8 million RSF of our value-creation projects, which are 78% leased/negotiating, are either under construction or expected to commence construction in the next six quarters.
Continued dividend strategy to share growth in cash flows with stockholders
Common stock dividend declared for 2Q22 of $1.18 per common share, aggregating $4.60 per common share for the twelve months ended June 30, 2022, up 24 cents, or 6%, over the twelve months ended June 30, 2021. Our FFO payout ratio of 56% for the three months ended June 30, 2022 allows us to continue to share growth in cash flows from operating activities with our stockholders while also retaining a significant portion for reinvestment.
Seventh overall Nareit Investor CARE Award winner
We received the 2022 Nareit Investor CARE (Communications and Reporting Excellence) Silver Award in the Large Cap Equity REIT category for superior shareholder communications and reporting. This represents our fifth consecutive and seventh overall Nareit Investor CARE Award since 2015, demonstrating consistency in delivering best-in-class transparency, quality, and efficiency in communications and reporting to the investment community.
Key items included in operating results
Key items included in net income attributable to Alexandria's common stockholders:
(In millions, except per share amounts)
Amount Per Share - Diluted Amount Per Share - Diluted
2Q22 2Q21 2Q22 2Q21 1H22 1H21 1H22 1H21
Unrealized (losses) gains on non-real estate investments $ (68.1) $ 244.0 $ (0.42) $ 1.67 $ (331.6) $ 197.8 $ (2.07) $ 1.39
Significant realized gains on non-real estate investments - 34.8 - 0.24 - 57.7 - 0.41
Gain on sales of real estate 214.2 - 1.33 - 214.2 2.8 1.34 0.02
Impairment of real estate - (4.9) - (0.03) - (10.1) - (0.07)
Loss on early extinguishment of debt (3.3) - (0.02) - (3.3) (67.3) (0.02) (0.47)
Total
$ 142.8 $ 273.9 $ 0.89 $ 1.88 $ (120.7) $ 180.9 $ (0.75) $ 1.28

External growth and investment in real estate
Delivery and commencement of value-creation projects
•During 2Q22, we placed into service development and redevelopment projects aggregating 375,394 RSF across multiple submarkets.
•80% of construction costs related to active development and redevelopment projects aggregating 5.9 million RSF are under a guaranteed maximum price ("GMP") contract or other fixed contracts. Our budgets also include construction cost contingencies in GMP contracts plus additional landlord contingencies that generally range between 3% and 5%.
•Annual net operating income (cash basis) is expected to increase by $39 million upon the burn-off of initial free rent from recently delivered projects.
•During 2Q22, we commenced construction on six value-creation projects aggregating 917,599 RSF, including the following development projects:
•320,809 RSF, 36% leased, at 99 Coolidge Avenue in our Cambridge/Inner Suburbs submarket;
•248,018 RSF, 85% leased, at 500 North Beacon Street and 4 Kingsbury Avenue in our Cambridge/Inner Suburbs submarket;
•90,000 RSF, 29% leased, at 9808 Medical Center Drive in our Rockville submarket; and
•88,038 RSF, 100% leased, at our expansion at 6040 George Watts Hill Drive in our Research Triangle submarket.
•As of 2Q22, our highly leased value-creation pipeline of current and key near-term projects that are under construction or that will commence construction in the next six quarters aggregates 7.8 million RSF and is 78% leased/negotiating.

Value-creation pipeline of new Class A development and redevelopment projects as a percentage of gross assets 2Q22
Under construction projects 75% leased/negotiating
10%
Pre-leased/negotiating near-term projects expected to commence construction in the next six quarters 89% leased/negotiating
1%
Income-producing/potential cash flows/covered land play(1)
8%
Land 2%
(1)Includes projects that have existing buildings that are generating or can generate operating cash flows. Also includes development rights associated with existing operating campuses.
Alexandria is at the vanguard of innovation for a high-quality roster of over 1,000 tenants, with a focus on accommodating their current needs and providing them with a path for future growth
•Reduced the upper end of our range of 2022 guidance for acquisitions by $750 million to a range from $2.6 billion to $2.8 billion.
•During 2Q22, we completed acquisitions in our key life science cluster submarkets aggregating 1.1 million RSF of future development and redevelopment opportunities for an aggregate purchase price of $280.1 million.

Second Quarter Ended June 30, 2022 Financial and Operating Results (continued)
June 30, 2022
Balance sheet management
Key metrics as of June 30, 2022
•$33.7 billion in total market capitalization.
•$23.4 billion in total equity capitalization, which ranks in the top 10% among all publicly traded U.S. REITs.
•No debt maturities prior to 2025.
•13.6 years weighted-average remaining term of debt.
2Q22 Goal
Quarter Trailing 4Q22
Annualized 12 Months Annualized
Net debt and preferred stock to Adjusted EBITDA 5.5x 5.9x Less than or equal to 5.1x
Fixed-charge coverage ratio 5.1x 5.1x Greater than or equal to 5.1x
Key capital events
•During 2Q22, we entered into new forward equity sales agreements aggregating $403.4 million to sell 2.4 million shares under our ATM program at an average price of $169.38 per share (before underwriting discounts). As of June 30, 2022, the remaining aggregate amount available under our ATM program for future sales of common stock was $246.6 million.
•During 2Q22, we did not issue shares to settle our outstanding forward equity agreements. We expect to issue an aggregate of 9.0 million shares at an average price of $187.91 per share to settle all our outstanding forward equity sales agreements and receive net proceeds of approximately $1.7 billion in 2H22.
•In April 2022, we repaid two secured notes payable aggregating $195.0 million due in 2024 with an effective interest rate of 3.40%. As a result, we recognized a loss on early extinguishment of debt of $3.3 million.
Investments
•As of June 30, 2022:
•Our investments aggregated $1.7 billion.
•Unrealized gains presented in our consolidated balance sheets were $459.8 million, comprising gross unrealized gains and losses aggregating $565.5 million and $105.7 million, respectively.
•Investment loss of $39.5 million, presented in our consolidated statements of operations, consisted of $28.6 million of realized gains and $68.1 million of unrealized losses/changes in fair value.
Subsequent event
•On July 1, 2022, Stephen A. Richardson, our Co-Chief Executive Officer, tendered his resignation from all of his positions with the Company and its subsidiaries, effective July 31, 2022, and notified the Company of his intent to retire from full-time employment and his professional career for family and personal reasons.
Industry and ESG leadership: catalyzing and leading the way for positive change to benefit human health and society
•In June 2022, we released our 2021 ESG Report, which highlights our longstanding ESG leadership. The report details our efforts to advance our ESG impact, including by driving high-performance building design and operations to reduce carbon emissions, mitigating climate-related risk in our real estate portfolio, and investing in and providing essential infrastructure for sustainable agrifoodtech companies. It also showcases Alexandria's comprehensive efforts to catalyze the health, wellness, safety, and productivity of our employees, tenants, local communities, and the world through the built environment and beyond, including through our visionary social responsibility endeavors. Notable initiatives presented in the report that highlight our innovative approach include:
•Furthering the development of our approach to physical and transitional climate-related risk by initiating a process to assess and understand potential physical risk and pathways to mitigate and adapt to climate change, as well as preparing for the transition to a low-carbon economy and continuing to develop science-based targets;
•Implementing innovative solutions to minimize fossil fuel use in our state-of-the-art laboratory development projects, such as at 325 Binney Street, which will harness geothermal energy to target a LEED Zero Energy certification and a 92% reduction in fossil fuel use as a key component of its design to be the most sustainable laboratory building in Cambridge; at 751 Gateway Boulevard, which is pursuing electrification and is tracking to be the first all-electric laboratory building in South San Francisco; and at the Alexandria Center® for Life Science - South Lake Union mega campus in Seattle, where the Company is incorporating an innovative wastewater heat recovery system; and
•Increasing our investment in renewable electricity to mitigate carbon emissions in our existing asset base, including through a large-scale solar power purchase agreement that will significantly increase the supply of renewable electricity to our Greater Boston market starting in 2024.
About Alexandria Real Estate Equities, Inc.
Alexandria Real Estate Equities, Inc. (NYSE:ARE), an S&P 500® urban office REIT, is the first, longest-tenured, and pioneering owner, operator, and developer uniquely focused on collaborative life science, agtech, and technology campuses in AAA innovation cluster locations, with a total market capitalization of $33.7 billion and an asset base in North America of 74.1 million SF as of June 30, 2022. The asset base in North America includes 41.1 million RSF of operating properties and 5.9 million RSF of Class A properties undergoing construction, 9.9 million RSF of near-term and intermediate-term development and redevelopment projects, and 17.2 million SF of future development projects. Founded in 1994, Alexandria pioneered this niche and has since established a significant market presence in key locations, including Greater Boston, the San Francisco Bay Area, New York City, San Diego, Seattle, Maryland, and Research Triangle. Alexandria has a longstanding and proven track record of developing Class A properties clustered in urban life science, agtech, and technology campuses that provide our innovative tenants with highly dynamic and collaborative environments that enhance their ability to successfully recruit and retain world-class talent and inspire productivity, efficiency, creativity, and success. Alexandria also provides strategic capital to transformative life science, agtech, and technology companies through our venture capital platform. We believe our unique business model and diligent underwriting ensure a high-quality and diverse tenant base that results in higher occupancy levels, longer lease terms, higher rental income, higher returns, and greater long-term asset value. For additional information on Alexandria, please visit www.are.com.
Acquisitions
June 30, 2022
(Dollars in thousands)
Property Submarket/Market Date of
Purchase
Number of Properties Operating
Occupancy
Square Footage Purchase Price
Acquisitions With Development/Redevelopment Opportunities(1)
Future Development Operating With Future Development/ Redevelopment
Operating(2)
Operating
Total(3)
Completed in 1Q22 29 91 % 4,617,991 2,668,494 451,760 - 7,306,305 $ 1,840,717
Completed in 2Q22:
One Hampshire Street(4)
Cambridge/Inner Suburbs/
Greater Boston
6/23/22 1 100 % - 88,591 - - 88,591 140,000
Other Various Various 2 76 869,000 109,557 - - 978,557 140,146
3 87 % 869,000 198,148
(5)
-
(5)
-
(5)
1,067,148 280,146
Completed in July 2022 9,561
2,130,424
Pending(6)
Various 3Q22 275,000
Other 244,576
2022 acquisitions (midpoint) $ 2,650,000
2022 guidance range(7)
$2,550,000 - $2,750,000

(1)We expect to provide total estimated costs and related yields for development and redevelopment projects in the future, subsequent to the commencement of construction.
(2)Represents the operating component of our value-creation acquisitions that is not expected to undergo future development or redevelopment.
(3)Represents total square footage upon completion of development or redevelopment of a new Class A property. Square footage presented includes RSF of buildings currently in operation with future development or redevelopment opportunities. We intend to demolish and develop or to redevelop the existing properties upon expiration of the existing in-place leases. Refer to "Definitions and reconciliations" in our Supplemental Information for additional details on value-creation square feet currently included in rental properties.
(4)Represents the acquisition of a condominium in two floors of a seven-story building.
(5)We expect the acquisitions completed during the three months ended June 30, 2022 to generate initial annual net operating income of approximately $9 million for the twelve months following acquisition. These acquisitions included three operating properties with a weighted-average acquisition date of June 16, 2022 (weighted by initial annual net operating income).
(6)Represents acquisitions of land parcels to expand our mega campuses in our Cambridge and University Town Center submarkets.
(7)We reduced the upper end of our range of 2022 guidance for acquisitions by $750 million. Refer to "Guidance" on page 6 of this Earnings Press Release for additional information.
Dispositions and Sales of Partial Interest
June 30, 2022
(Dollars in thousands)
Capitalization Rate
(Cash Basis)
Sales Price per RSF Gain or Consideration in Excess of Book Value
Property Submarket/Market Date of Sale Interest Sold RSF Capitalization Rate Sales Price
Completed 1H22:
100 Binney Street Cambridge/Inner Suburbs/Greater Boston 3/30/22 70 % 432,931 3.6 % 3.5 % $ 713,228
(1)
$ 2,353 $ 413,615
(2)
300 Third Street Cambridge/Inner Suburbs/Greater Boston 6/27/22 70 % 131,963 4.6 % 4.3 % 166,485
(1)
$ 1,802 113,020
(2)
Alexandria Park at 128, 285 Bear Hill Road, 111 and 130 Forbes Boulevard, and 20 Walkup Drive Route 128 and Route 495/Greater Boston 6/8/22 100 % 617,043 5.1 % 5.1 % 334,397 $ 542 202,325
Other N/A N/A 47,800 N/A 11,895
1,261,910 $ 740,855
Completed in July 2022:
1450 Owens Street Mission Bay/San Francisco Bay Area 7/1/22 20 %
(3)
191,000 N/A N/A 25,039
(1)
N/A $ 10,083
(2)
1,286,949
Pending San Diego 3Q22 TBD TBD 140,000 - 160,000 TBD
Other TBD TBD TBD 588,051 TBD
2022 dispositions (midpoint) $ 2,025,000
2022 guidance range $1,450,000 - $2,600,000

(1)Represents the contractual sales price for the percentage interest of the property sold by us.
(2)We retained control over the newly formed real estate joint venture and therefore continued to consolidate this property. We accounted for the difference between the consideration received and the book value of the interest sold as an equity transaction, with no gain or loss recognized in earnings.
(3)Relates to the sale of a land parcel. Upon completion of the transaction, the noncontrolling interest share for our joint venture partner is 20% and is anticipated to increase to 75% as our partner contributes capital for construction over time.

Guidance
June 30, 2022
(Dollars in millions)
The following updated guidance is based on our current view of existing market conditions and assumptions for the year ending December 31, 2022. There can be no assurance that actual amounts will not be materially higher or lower than these expectations. Also, refer to our discussion of "forward-looking statements" on page 8 of this Earnings Press Release for
additional details.

Key changes to our guidance include the reduction of an aggregate $635 million to our uses of capital, comprising a $350 million reduction in acquisitions and a $285 million reduction in construction spending. This reduction was offset by construction spending from January through June 2022, which increased by $335 million to slightly above the high end of our previous guidance range, as a result of construction spending associated with the leasing of our development and redevelopment projects under construction and our near-term pipeline projects. In addition, the midpoint of our guidance for funds from operations per share, as adjusted increased by three cents driven by strong same property performance and general and administrative savings in 2H22 resulting from the retirement of Stephen A. Richardson, our Co-Chief Executive Officer.
2022 Guidance
Reduction in uses of capital Reduction Summary of key changes in guidance As of 7/25/22 As of 4/25/22
Construction $285 EPS, FFO per share, and FFO per share, as adjusted
Refer to page 7
Acquisitions $350 Same property net operating income increase 6.0% to 8.0% 5.9% to 7.9%
Same property net operating income increase (cash basis) 6.8% to 8.8% 6.5% to 8.5%
General and administrative expenses $172 to $180 $168 to $176

As of 7/25/22
Key Sources and Uses of Capital
Range Midpoint Certain
Completed Items
As of 4/25/22
Midpoint
Key Changes to Midpoint
Sources of capital:
Net cash provided by operating activities after dividends $ 275 $ 325 $ 300 $ 300
Net incremental debt 1,361 561 961 See below 950
Dispositions and sales of partial interest (refer to page 5)
1,450 2,600 2,025 $ 1,287 1,950 $ 75
Common equity 2,364 2,364 2,364 $ 2,364
(1)
2,750 $ (386)
Total sources of capital $ 5,450 $ 5,850 $ 5,650 $ 5,950
Uses of capital:
Construction $ 2,900 $ 3,100 $ 3,000 $ 2,950 $ 50
Acquisitions (refer to page 4)
2,550 2,750 2,650 $ 2,130 3,000 $ (350)
Total uses of capital
$ 5,450 $ 5,850 $ 5,650 $ 5,950
Incremental debt (included above):
Issuance of unsecured senior notes payable $ 1,800 $ 1,800 $ 1,800 $ 1,800 $ 1,800
Repayments of secured notes payable (195) (195) (195) $ (195) (195)
Unsecured senior line of credit, commercial paper, and other (44) (744) (394) (655)
Incremental cash expected to be held at December 31, 2022(2)
(200) (300) (250) - $ (250)
Net incremental debt $ 1,361 $ 561 $ 961 $ 950

(1)Refer to "Key capital events" on page 3 of this Earnings Press Release for additional details. During the six months ended June 30, 2022, we entered into new forward equity sales agreements aggregating $2.4 billion to sell 12.3 million shares of our common stock. During 1Q22, we settled a portion of these forward equity sales agreements by issuing 3.2 million shares and received net proceeds of $648.2 million. We expect to issue 9.0 million shares to settle our remaining outstanding forward equity sales agreements and receive net proceeds of approximately $1.7 billion in 2022.
(2)We expect this forecasted cash at December 31, 2022 to result in a reduction of our 2023 debt capital needs.

Guidance (continued)
June 30, 2022
(Dollars in millions, except per share amounts)
Projected 2022 Earnings per Share and Funds From Operations per Share Attributable to Alexandria's Common Stockholders - Diluted
As of 7/25/22 As of 4/25/22
Earnings per share(1)
$2.14 to $2.20 $1.08 to $1.18
Depreciation and amortization of real estate assets 5.50 5.65
Gain on sales of real estate (1.34) -
Allocation to unvested restricted stock awards (0.02) (0.02)
Funds from operations per share(2)
$6.28 to $6.34 $6.71 to $6.81
Unrealized losses on non-real estate investments 2.07 1.67
Loss on early extinguishment of debt(3)
0.02 0.02
Acceleration of stock compensation due to executive officer resignation(4)
0.04 -
Allocation to unvested restricted stock awards (0.02) (0.02)
Other (0.01) (0.05)
Funds from operations per share, as adjusted(1)
$8.38 to $8.44 $8.33 to $8.43
Midpoint $8.41 $8.38

As of 7/25/22 As of 4/25/22
Key Assumptions
Low High Low High
Occupancy percentage in North America as of December 31, 2022
95.2% 95.8% 95.2% 95.8%
Lease renewals and re-leasing of space:
Rental rate increases
30.0% 35.0% 30.0% 35.0%
Rental rate increases (cash basis)
18.0% 23.0% 18.0% 23.0%
Same property performance:
Net operating income increase
6.0% 8.0% 5.9% 7.9%
Net operating income increase (cash basis)
6.8% 8.8% 6.5% 8.5%
Straight-line rent revenue(5)
$ 144 $ 154 $ 154 $ 164
General and administrative expenses(4)
$ 172 $ 180 $ 168 $ 176
Capitalization of interest
$ 269 $ 279 $ 269 $ 279
Interest expense
$ 90 $ 100 $ 90 $ 100

Key Credit Metrics As of 7/25/22 As of 4/25/22
Net debt and preferred stock to Adjusted EBITDA - 4Q22 annualized
Less than or equal to 5.1x Less than or equal to 5.1x
Fixed-charge coverage ratio - 4Q22 annualized
Greater than or equal to 5.1x Greater than or equal to 5.1x

(1)Excludes unrealized gains or losses after June 30, 2022 that are required to be recognized in earnings and are excluded from funds from operations per share, as adjusted.
(2)Refer to "Funds from operations and funds from operations, as adjusted, attributable to Alexandria's common stockholders" in the "Definitions and reconciliations" of our Supplemental Information for additional details.
(3)Refer to "Key capital events" on page 3 of this Earnings Press Release for additional details.
(4)Relates to the resignation of an executive officer in July 2022. General & administrative expenses increased by $4 million, including $7 million related to the acceleration of stock compensation due to the resignation of Stephen A. Richardson, our Co-Chief Executive Officer, partially offset by compensation savings in 2H22. Refer to "Subsequent event" on page 3 of this Earnings Press release for additional information.
(5)The $10 million reduction in our guidance range for straight-line rent revenue includes reductions attributable to the following items:
•Changes to our capital plan for 2022 as highlighted in our updated guidance for key sources and uses of capital on the previous page, including the following:
•Lower acquisitions with operating activities in 2022 as well as the $350 million reduction in the midpoint of our guidance range for acquisitions; and
•Higher dispositions compared to sales of partial interest.
•Acceleration of $2 million contractual rental payments due under one long-term lease in our Cambridge/Inner Suburbs submarket.
•Early terminations of below-market leases:
•Includes two spaces aggregating 141,649 RSF in two markets, of which 51% has been re-leased at aggregate rental rate increases of 114% and 140% (cash basis). We expect the re-leased spaces to take occupancy by 3Q22.

Earnings Call Information and About the Company
June 30, 2022
We will host a conference call on Tuesday, July 26, 2022, at 3:00 p.m. Eastern Time ("ET")/noon Pacific Time ("PT"), which is open to the general public, to discuss our financial and operating results for the second quarter ended June 30, 2022. To participate in this conference call, dial (833) 366-1125 or (412) 902-6738 shortly before 3:00 p.m. ET/noon PT and ask the operator to join the call for Alexandria Real Estate Equities, Inc. The audio webcast can be accessed at www.are.com in the "For Investors" section. A replay of the call will be available for a limited time from 5:00 p.m. ET/2:00 p.m. PT on Tuesday, July 26, 2022. The replay number is (877) 344-7529 or (412) 317-0088, and the access code is 7939670.

Additionally, a copy of this Earnings Press Release and Supplemental Information for the second quarter ended June 30, 2022 is available in the "For Investors" section of our website at www.are.com or by following this link: https://www.are.com/fs/2022q2.pdf.

For any questions, please contact Joel S. Marcus, executive chairman and founder; Peter M. Moglia, co-chief executive officer and co-chief investment officer; Stephen A. Richardson, co-chief executive officer; Dean A. Shigenaga, president and chief financial officer; Paula Schwartz, managing director of Rx Communications Group, at (917) 633-7790; or Sara M. Kabakoff, vice president - communications, at (626) 578-0777.

About the Company

Alexandria Real Estate Equities, Inc. (NYSE:ARE), an S&P 500® urban office real estate investment trust ("REIT"), is the first, longest-tenured, and pioneering owner, operator, and developer uniquely focused on collaborative life science, agtech, and technology campuses in AAA innovation cluster locations, with a total market capitalization of $33.7 billion and an asset base in North America of 74.1 million square feet ("SF") as of June 30, 2022. The asset base in North America includes 41.1 million RSF of operating properties and 5.9 million RSF of Class A properties undergoing construction, 9.9 million RSF of near-term and intermediate-term development and redevelopment projects, and 17.2 million SF of future development projects. Founded in 1994, Alexandria pioneered this niche and has since established a significant market presence in key locations, including Greater Boston, the San Francisco Bay Area, New York City, San Diego, Seattle, Maryland, and Research Triangle. Alexandria has a longstanding and proven track record of developing Class A properties clustered in urban life science, agtech, and technology campuses that provide our innovative tenants with highly dynamic and collaborative environments that enhance their ability to successfully recruit and retain world-class talent and inspire productivity, efficiency, creativity, and success. Alexandria also provides strategic capital to transformative life science, agtech, and technology companies through our venture capital platform. We believe our unique business model and diligent underwriting ensure a high-quality and diverse tenant base that results in higher occupancy levels, longer lease terms, higher rental income, higher returns, and greater long-term asset value. For additional information on Alexandria, please visit www.are.com.

***********

This document includes "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements include, without limitation, statements regarding our 2022 earnings per share attributable to Alexandria's common stockholders - diluted, 2022 funds from operations per share attributable to Alexandria's common stockholders - diluted, net operating income, and our projected sources and uses of capital. You can identify the forward-looking statements by their use of forward-looking words, such as "forecast," "guidance," "goals," "projects," "estimates," "anticipates," "believes," "expects," "intends," "may," "plans," "seeks," "should," "targets," or "will," or the negative of those words or similar words. These forward-looking statements are based on our current expectations, beliefs, projections, future plans and strategies, anticipated events or trends, and similar expressions concerning matters that are not historical facts, as well as a number of assumptions concerning future events. There can be no assurance that actual results will not be materially higher or lower than these expectations. These statements are subject to risks, uncertainties, assumptions, and other important factors that could cause actual results to differ materially from the results discussed in the forward-looking statements. Factors that might cause such a difference include, without limitation, our failure to obtain capital (debt, construction financing, and/or equity) or refinance debt maturities, lower than expected yields, increased interest rates and operating costs, adverse economic or real estate developments in our markets, our failure to successfully place into service and lease any properties undergoing development or redevelopment and our existing space held for future development or redevelopment (including new properties acquired for that purpose), our failure to successfully operate or lease acquired properties, decreased rental rates, increased vacancy rates or failure to renew or replace expiring leases, defaults on or non-renewal of leases by tenants, adverse general and local economic conditions, an unfavorable capital market environment, decreased leasing activity or lease renewals, failure to obtain LEED and other healthy building certifications and efficiencies, and other risks and uncertainties detailed in our filings with the Securities and Exchange Commission ("SEC"). Accordingly, you are cautioned not to place undue reliance on such forward-looking statements. All forward-looking statements are made as of the date of this Earnings Press Release and Supplemental Information, and unless otherwise stated, we assume no obligation to update this information and expressly disclaim any obligation to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise. For more discussion relating to risks and uncertainties that could cause actual results to differ materially from those anticipated in our forward-looking statements, and risks to our business in general, please refer to our SEC filings, including our most recent annual report on Form 10-K and any subsequent quarterly reports on Form 10-Q.

Alexandria®, Lighthouse Design® logo, Building the Future of Life-Changing Innovation®, That's What's in Our DNA®, At the Vanguard and Heart of the Life Science Ecosystem™, Alexandria Center®, Alexandria Technology Square®, Alexandria Technology Center®, and Alexandria Innovation Center® are copyrights and trademarks of Alexandria Real Estate Equities, Inc. All other company names, trademarks, and logos referenced herein are the property of their respective owners.
Consolidated Statements of Operations
June 30, 2022
(Dollars in thousands, except per share amounts)
Three Months Ended Six Months Ended
6/30/22

3/31/22 12/31/21 9/30/21 6/30/21 6/30/22 6/30/21
Revenues:
Income from rentals $ 640,959 $ 612,554 $ 574,656 $ 546,527 $ 508,371 $ 1,253,513 $ 987,066
Other income 2,805 2,511 2,267 1,232 1,248 5,316 2,402
Total revenues 643,764 615,065 576,923 547,759 509,619 1,258,829 989,468
Expenses:
Rental operations 196,284 181,328 175,717 165,995 143,955 377,612 281,843
General and administrative 43,397 40,931 41,654 37,931 37,880 84,328 71,876
Interest 24,257 29,440 34,862 35,678 35,158 53,697 71,625
Depreciation and amortization 242,078 240,659 239,254 210,842 190,052 482,737 370,965
Impairment of real estate - - - 42,620 4,926 - 10,055
Loss on early extinguishment of debt 3,317 - - - - 3,317 67,253
Total expenses 509,333 492,358 491,487 493,066 411,971 1,001,691 873,617
Equity in earnings of unconsolidated real estate joint ventures 213 220 3,018 3,091 2,609 433 6,146
Investment (loss) income (39,481) (240,319) (112,884) 67,084 304,263 (279,800) 305,277
Gain (loss) on sales of real estate 214,219 - 124,226 (435) - 214,219 2,779
Net income (loss) 309,382 (117,392) 99,796 124,433 404,520 191,990 430,053
Net income attributable to noncontrolling interests (37,168) (32,177) (24,901) (21,286) (19,436) (69,345) (36,848)
Net income (loss) attributable to Alexandria Real Estate Equities, Inc.'s stockholders 272,214 (149,569) 74,895 103,147 385,084 122,645 393,205
Net income attributable to unvested restricted stock awards
(2,934) (2,081) (2,098) (1,883) (4,521) (4,134) (4,663)
Net income (loss) attributable to Alexandria Real Estate Equities, Inc.'s common stockholders $ 269,280 $ (151,650) $ 72,797 $ 101,264 $ 380,563 $ 118,511 $ 388,542
Net income (loss) per share attributable to Alexandria Real Estate Equities, Inc.'s common stockholders:
Basic $ 1.67 $ (0.96) $ 0.47 $ 0.67 $ 2.61 $ 0.74 $ 2.74
Diluted $ 1.67 $ (0.96) $ 0.47 $ 0.67 $ 2.61 $ 0.74 $ 2.74
Weighted-average shares of common stock outstanding:
Basic 161,412 158,198 153,464 150,854 145,825 159,814 141,596
Diluted 161,412 158,198 154,307 151,561 146,058 159,814 141,896
Dividends declared per share of common stock $ 1.18 $ 1.15 $ 1.15 $ 1.12 $ 1.12 $ 2.33 $ 2.21

Consolidated Balance Sheets
June 30, 2022
(In thousands)

6/30/22 3/31/22 12/31/21 9/30/21 6/30/21
Assets
Investments in real estate $ 27,952,931 $ 27,100,009 $ 24,980,669 $ 23,071,514 $ 21,692,385
Investments in unconsolidated real estate joint ventures 37,587 38,456 38,483 321,737 323,622
Cash and cash equivalents 420,258 775,060 361,348 325,872 323,876
Restricted cash 97,404 95,106 53,879 42,182 33,697
Tenant receivables 7,069 7,570 7,379 7,749 6,710
Deferred rent 905,699 881,743 839,335 816,219 781,600
Deferred leasing costs 498,434 484,184 402,898 329,952 321,005
Investments 1,657,461 1,661,101 1,876,564 2,046,878 1,999,283
Other assets 1,667,210 1,801,027 1,658,818 1,596,615 1,536,672
Total assets $ 33,244,053 $ 32,844,256 $ 30,219,373 $ 28,558,718 $ 27,018,850
Liabilities, Noncontrolling Interests, and Equity
Secured notes payable $ 24,986 $ 208,910 $ 205,198 $ 198,758 $ 227,984
Unsecured senior notes payable 10,096,462 10,094,337 8,316,678 8,314,851 8,313,025
Unsecured senior line of credit and commercial paper 149,958 - 269,990 749,978 299,990
Accounts payable, accrued expenses, and other liabilities
2,317,940 2,172,692 2,210,410 2,149,450 1,825,387
Dividends payable 192,571 187,701 183,847 173,560 170,647
Total liabilities 12,781,917 12,663,640 11,186,123 11,586,597 10,837,033
Commitments and contingencies
Redeemable noncontrolling interests 9,612 9,612 9,612 11,681 11,567
Alexandria Real Estate Equities, Inc.'s stockholders' equity:
Common stock
1,615 1,614 1,580 1,532 1,507
Additional paid-in capital 17,149,571 16,934,094 16,195,256 14,727,735 14,194,023
Accumulated other comprehensive loss (11,851) (5,727) (7,294) (6,029) (4,508)
Alexandria Real Estate Equities, Inc.'s stockholders' equity 17,139,335 16,929,981 16,189,542 14,723,238 14,191,022
Noncontrolling interests 3,313,189 3,241,023 2,834,096 2,237,202 1,979,228
Total equity 20,452,524 20,171,004 19,023,638 16,960,440 16,170,250
Total liabilities, noncontrolling interests, and equity
$ 33,244,053 $ 32,844,256 $ 30,219,373 $ 28,558,718 $ 27,018,850

Funds From Operations and Funds From Operations per Share
June 30, 2022
(In thousands)
The following table presents a reconciliation of net income (loss) attributable to Alexandria's common stockholders, the most directly comparable financial measure presented in accordance with U.S. generally accepted accounting principles ("GAAP"), including our share of amounts from consolidated and unconsolidated real estate joint ventures, to funds from operations attributable to Alexandria's common stockholders - diluted, and funds from operations attributable to Alexandria's common stockholders - diluted, as adjusted, for the periods below:

Three Months Ended Six Months Ended
6/30/22 3/31/22 12/31/21 9/30/21 6/30/21 6/30/22 6/30/21
Net income (loss) attributable to Alexandria's common stockholders $ 269,280 $ (151,650) $ 72,797 $ 101,264 $ 380,563 $ 118,511 $ 388,542
Depreciation and amortization of real estate assets 238,565 237,160 234,979 205,436 186,498 475,725 364,218
Noncontrolling share of depreciation and amortization from consolidated real estate JVs
(26,418) (23,681) (21,265) (17,871) (16,301) (50,099) (31,744)
Our share of depreciation and amortization from unconsolidated real estate JVs
934 955 3,058 3,465 4,135 1,889 7,211
(Gain) loss on sales of real estate (214,219) - (124,226) 435 - (214,219) (2,779)
Impairment of real estate - rental properties
- - - 18,602 1,754 - 6,883
Allocation to unvested restricted stock awards
- - - (1,472) (2,191) - (4,427)
Funds from operations attributable to Alexandria's common stockholders - diluted(1)
268,142 62,784 165,343 309,859 554,458 331,807 727,904
Unrealized losses (gains) on non-real estate investments 68,128 263,433 139,716 14,432 (244,031) 331,561 (197,780)
Significant realized gains on non-real estate investments - - - (52,427) (34,773) - (57,692)
Impairment of real estate
- - - 24,018 3,172 - 3,172
Loss on early extinguishment of debt
3,317 - - - - 3,317 67,253
Allocation to unvested restricted stock awards
(778) (1,604) (1,432) 149 3,428 (3,264) 2,382
Funds from operations attributable to Alexandria's common stockholders - diluted, as adjusted $ 338,809 $ 324,613 $ 303,627 $ 296,031 $ 282,254 $ 663,421 $ 545,239

(1)Calculated in accordance with standards established by the Nareit Board of Governors.
Funds From Operations and Funds From Operations per Share (continued)
June 30, 2022
(In thousands, except per share amounts)

The following table presents a reconciliation of net income (loss) per share attributable to Alexandria's common stockholders, the most directly comparable financial measure presented in accordance with GAAP, including our share of amounts from consolidated and unconsolidated real estate joint ventures, to funds from operations per share attributable to Alexandria's common stockholders - diluted, and funds from operations per share attributable to Alexandria's common stockholders - diluted, as adjusted, for the periods below. Per share amounts may not add due to rounding.

Three Months Ended Six Months Ended
6/30/22 3/31/22 12/31/21 9/30/21 6/30/21 6/30/22 6/30/21
Net income (loss) per share attributable to Alexandria's common stockholders - diluted $ 1.67 $ (0.96) $ 0.47 $ 0.67 $ 2.61 $ 0.74 $ 2.74
Depreciation and amortization of real estate assets
1.32 1.36 1.40 1.26 1.19 2.68 2.39
Gain on sales of real estate (1.33) - (0.80) - - (1.34) (0.02)
Impairment of real estate - rental properties - - - 0.12 0.01 - 0.05
Allocation to unvested restricted stock awards
- - - (0.01) (0.01) - (0.03)
Funds from operations per share attributable to Alexandria's common stockholders - diluted
1.66 0.40 1.07 2.04 3.80 2.08 5.13
Unrealized losses (gains) on non-real estate investments 0.42 1.67 0.91 0.10 (1.67) 2.07 (1.39)
Significant realized gains on non-real estate investments - - - (0.35) (0.24) - (0.41)
Impairment of real estate - - - 0.16 0.02 - 0.02
Loss on early extinguishment of debt
0.02 - - - - 0.02 0.47
Allocation to unvested restricted stock awards
- (0.02) (0.01) - 0.02 (0.02) 0.02
Funds from operations per share attributable to Alexandria's common stockholders - diluted, as adjusted
$ 2.10 $ 2.05 $ 1.97 $ 1.95 $ 1.93 $ 4.15 $ 3.84
Weighted-average shares of common stock outstanding for calculation of:
Earnings per share - diluted 161,412 158,198 154,307 151,561 146,058 159,814 141,896
Funds from operations, diluted, per share 161,412 158,209 154,307 151,561 146,058 159,814 141,896
Funds from operations, diluted, as adjusted, per share 161,412 158,209 154,307 151,561 146,058 159,814 141,896



SUPPLEMENTAL
INFORMATION


Company Profile
June 30, 2022
Alexandria Real Estate Equities, Inc. (NYSE:ARE), an S&P 500® urban office REIT, is the first, longest-tenured, and pioneering owner, operator, and developer uniquely focused on collaborative life science, agtech, and technology campuses in AAA innovation cluster locations, with a total market capitalization of $33.7 billion and an asset base in North America of 74.1 million SF as of June 30, 2022. The asset base in North America includes 41.1 million RSF of operating properties and 5.9 million RSF of Class A properties undergoing construction, 9.9 million RSF of near-term and intermediate-term development and redevelopment projects, and 17.2 million SF of future development projects. Founded in 1994, Alexandria pioneered this niche and has since established a significant market presence in key locations, including Greater Boston, the San Francisco Bay Area, New York City, San Diego, Seattle, Maryland, and Research Triangle. Alexandria has a longstanding and proven track record of developing Class A properties clustered in urban life science, agtech, and technology campuses that provide our innovative tenants with highly dynamic and collaborative environments that enhance their ability to successfully recruit and retain world-class talent and inspire productivity, efficiency, creativity, and success. Alexandria also provides strategic capital to transformative life science, agtech, and technology companies through our venture capital platform. We believe our unique business model and diligent underwriting ensure a high-quality and diverse tenant base that results in higher occupancy levels, longer lease terms, higher rental income, higher returns, and greater long-term asset value. For additional information on Alexandria, please visit www.are.com.

Tenant base

Alexandria is known for our high-quality and diverse tenant base, with 50% of our total annual rental revenue being generated from tenants that are investment-grade rated or publicly traded large cap companies. The quality, diversity, breadth, and depth of our significant relationships with our tenants provide Alexandria with high-quality and stable cash flows. Alexandria's underwriting team and long-term industry relationships positively distinguish us from all other publicly traded REITs and real estate companies.

Executive and senior management team

Alexandria's executive and senior management team has unique experience and expertise in creating, owning, and operating highly dynamic and collaborative campuses in key urban life science, agtech, and technology cluster locations that inspire innovation. From our development of high-quality, sustainable real estate to our ongoing cultivation of collaborative environments with unique amenities and events, the Alexandria team has a best-in-class reputation of excellence in our niche. Alexandria's highly experienced management team also includes regional market directors with leading reputations and longstanding relationships within the life science, agtech, and technology communities in their respective innovation clusters. We believe that our expertise, experience, reputation, and key relationships in the real estate, life science, agtech, and technology sectors provide Alexandria significant competitive advantages in attracting new business opportunities.
Alexandria's executive and senior management team consists of 62 individuals, averaging 24 years of real estate experience, including 12 years with Alexandria. Our executive management team alone averages 18 years with Alexandria.
EXECUTIVE MANAGEMENT TEAM
Joel S. Marcus Peter M. Moglia
Executive Chairman & Founder Co-Chief Executive Officer &
Co-Chief Investment Officer
Dean A. Shigenaga Stephen A. Richardson
President & Chief Financial Officer Co-Chief Executive Officer
Daniel J. Ryan Hunter L. Kass
Co-Chief Investment Officer & Regional Market Director - San Diego Executive Vice President - Regional Market Director - Greater Boston
John H. Cunningham Lawrence J. Diamond
Executive Vice President - Regional Market Director - New York City Co-Chief Operating Officer & Regional Market Director - Maryland
Vincent R. Ciruzzi Joseph Hakman
Chief Development Officer Co-Chief Operating Officer &
Chief Strategic Transactions Officer
Jackie B. Clem Marc E. Binda
General Counsel & Secretary Executive Vice President -
Finance & Treasurer
Andres R. Gavinet Gary D. Dean
Chief Accounting Officer Executive Vice President -
Real Estate Legal Affairs
Terezia C. Nemeth Onn C. Lee
Executive Vice President - Regional Market Director - San Francisco
Bay Area
Executive Vice President -
Accounting
Kristina A. Fukuzaki-Carlson Madeleine T. Alsbrook
Executive Vice President -
Business Operations
Executive Vice President -
Talent Management
Investor Information
June 30, 2022
Corporate Headquarters New York Stock Exchange Trading Symbol Information Requests
26 North Euclid Avenue Common stock: ARE Phone: (626) 578-0777
Pasadena, California 91101 Email: [email protected]
Website: www.are.com
Equity Research Coverage
Alexandria is currently covered by the following research analysts. This list may be incomplete and is subject to change as firms initiate or discontinue coverage of our company. Please note that any opinions, estimates, or forecasts regarding our historical or predicted performance made by these analysts are theirs alone and do not represent opinions, estimates, or forecasts of Alexandria or our management. Alexandria does not by our reference or distribution of the information below imply our endorsement of or concurrence with any opinions, estimates, or forecasts of these analysts. Interested persons may obtain copies of analysts' reports on their own as we do not distribute these reports. Several of these firms may, from time to time, own our stock and/or hold other long or short positions in our stock and may provide compensated services to us.

Bank of America Merrill Lynch Citigroup Global Markets Inc. JMP Securities RBC Capital Markets
Jamie Feldman Michael Bilerman / Michael Griffin Aaron Hecht Michael Carroll
(646) 855-5808 (212) 816-1383 / (212) 816-5871 (415) 835-3963 (440) 715-2649
Berenberg Capital Markets Evercore ISI J.P. Morgan Securities LLC Robert W. Baird & Co. Incorporated
Connor Siversky Sheila McGrath / Wendy Ma Anthony Paolone / Ray Zhong David Rodgers / Nicholas Thillman
(646) 949-9037 (212) 497-0882 / (212) 497-0870 (212) 622-6682 / (212) 622-5411 (216) 737-7341 / (414) 298-5053
BTIG, LLC Green Street Mizuho Securities USA LLC SMBC Nikko Securities America, Inc.
Tom Catherwood / John Nickodemus Daniel Ismail / Dylan Burzinski Vikram Malhotra / Georgi Dinkov Richard Anderson / Jay Kornreich
(212) 738-6140 / (212) 738-6050 (949) 640-8780 / (949) 640-8780 (212) 282-3827 / (617) 352-1721 (646) 521-2351 / (646) 424-3202
CFRA
Kenneth Leon
(646) 517-2552
Fixed Income Coverage Rating Agencies
Barclays Capital Inc. Stifel Financial Corp. Moody's Investors Service S&P Global Ratings
Srinjoy Banerjee Thierry Perrein (212) 553-0376 Fernanda Hernandez / Michael Souers
(212) 526-3521 (646) 376-5303 (212) 438-1347 / (212) 438-2508
J.P. Morgan Securities LLC
Mark Streeter / Ian Snyder
(212) 834-5086 / (212) 834-3798
Financial and Asset Base Highlights
June 30, 2022
(Dollars in thousands, except per share amounts)
Three Months Ended (unless stated otherwise)
6/30/22 3/31/22 12/31/21 9/30/21 6/30/21
Selected financial data from consolidated financial statements and related information
Rental revenues
$ 485,067 $ 469,537 $ 435,637 $ 415,918 $ 396,804
Tenant recoveries
$ 155,892 $ 143,017 $ 139,019 $ 130,609 $ 111,567
General and administrative expenses $ 43,397 $ 40,931 $ 41,654 $ 37,931 $ 37,880
General and administrative expenses as a percentage of net operating income -
trailing 12 months
9.8% 10.0% 10.2% 10.1% 9.8%
Operating margin 70% 71% 70% 70% 72%
Adjusted EBITDA margin
70% 71% 71% 71% 73%
Adjusted EBITDA - quarter annualized
$ 1,797,488 $ 1,734,956 $ 1,631,244 $ 1,557,652 $ 1,483,576
Adjusted EBITDA - trailing 12 months
$ 1,680,335 $ 1,601,857 $ 1,517,838 $ 1,442,929 $ 1,371,586
Net debt at end of period
$ 9,832,722 $ 9,514,256 $ 8,442,115 $ 8,960,645 $ 8,550,339
Net debt and preferred stock to Adjusted EBITDA - quarter annualized 5.5x 5.5x 5.2x 5.8x 5.8x
Net debt and preferred stock to Adjusted EBITDA - trailing 12 months 5.9x 5.9x 5.6x 6.2x 6.2x
Total debt and preferred stock at end of period $ 10,271,406 $ 10,303,247 $ 8,791,866 $ 9,263,587 $ 8,840,999
Gross assets at end of period $ 37,304,589 $ 36,795,922 $ 33,990,614 $ 32,173,158 $ 30,480,630
Total debt and preferred stock to gross assets at end of period 28% 28% 26% 29% 29%
Fixed-charge coverage ratio - quarter annualized
5.1x 5.1x 5.3x 5.1x 4.9x
Fixed-charge coverage ratio - trailing 12 months
5.1x 5.1x 5.0x 4.8x 4.6x
Unencumbered net operating income as a percentage of total net operating income
100% 97% 97% 97% 97%
Closing stock price at end of period
$ 145.03 $ 201.25 $ 222.96 $ 191.07 $ 181.94
Common shares outstanding (in thousands) at end of period
161,456 161,408 158,044 153,284 150,708
Total equity capitalization at end of period
$ 23,415,970 $ 32,483,420 $ 35,237,463 $ 29,287,880 $ 27,419,791
Total market capitalization at end of period
$ 33,687,376 $ 42,786,667 $ 44,029,329 $ 38,551,467 $ 36,260,790
Dividend per share - quarter/annualized
$1.18/$4.72 $1.15/$4.60 $1.15/$4.60 $1.12/$4.48 $1.12/$4.48
Dividend payout ratio for the quarter
56% 57% 60% 58% 60%
Dividend yield - annualized
3.3% 2.3% 2.1% 2.3% 2.5%
Amounts related to operating leases:
Operating lease liabilities at end of period $ 412,535 $ 405,818 $ 434,745 $ 371,538 $ 371,905
Rent expense
$ 7,924 $ 7,718 $ 7,124 $ 6,228 $ 6,213
Capitalized interest
$ 68,202 $ 57,763 $ 44,078 $ 43,185 $ 43,492
Weighted-average interest rate for capitalization of interest during the period
3.56% 3.26% 3.22% 3.30% 3.47%
Financial and Asset Base Highlights (continued)
June 30, 2022
(Dollars in thousands, except annual rental revenue per occupied RSF amounts)
Three Months Ended (unless stated otherwise)
6/30/22 3/31/22 12/31/21 9/30/21 6/30/21
Amounts included in funds from operations and non-revenue-enhancing capital expenditures
Straight-line rent revenue
$ 27,362 $ 42,025 $ 25,942 $ 33,918 $ 27,903
Amortization of acquired below-market leases
$ 16,760 $ 13,915 $ 15,737 $ 13,664 $ 13,267
Straight-line rent expense on ground leases $ 354 $ 416 $ 301 $ 58 $ 248
Stock compensation expense
$ 14,340 $ 14,028 $ 14,253 $ 9,728 $ 12,242
Amortization of loan fees
$ 3,236 $ 3,103 $ 2,911 $ 2,854 $ 2,859
Amortization of debt (discounts) premiums $ (267) $ 424 $ 502 $ 498 $ 465
Non-revenue-enhancing capital expenditures:
Building improvements
$ 4,199 $ 4,110 $ 4,027 $ 3,901 $ 3,669
Tenant improvements and leasing commissions
$ 24,562 $ 27,791 $ 109,516 $ 16,409 $ 47,439
Operating statistics and related information (at end of period)
Number of properties - North America
436 446 414 407 381
RSF - North America (including development and redevelopment projects under construction)
46,934,653 47,364,067 43,670,737 43,044,195 40,076,883
Total square feet - North America
74,087,636 74,185,859 66,970,705 63,858,780 58,108,390
Annual rental revenue per occupied RSF - North America $ 50.80 $ 49.42 $ 48.65 $ 47.73 $ 48.65
Occupancy of operating properties - North America 94.6% 94.7% 94.0% 94.4% 94.3%
Occupancy of operating properties - North America (excluding vacancy at recently acquired properties) 98.4%
(1)
98.6% 98.7% 98.5% 98.1%
Occupancy of operating and redevelopment properties - North America 89.0% 88.9% 88.5% 89.6% 90.1%
Weighted-average remaining lease term (in years)
7.1 7.3 7.5 7.4 7.5
Total leasing activity - RSF
2,279,758 2,463,438 4,094,174 1,810,630 1,933,838
Lease renewals and re-leasing of space - change in average new rental rates over expiring rates:
Rental rate increases
45.4% 32.2% 35.9% 35.3% 42.4%
Rental rate increases (cash basis) 33.9% 16.5% 22.9% 19.3% 25.4%
RSF (included in total leasing activity above) 1,087,082 864,077 1,947,727 671,775 1,472,713
Same property - percentage change over comparable quarter from prior year:
Net operating income increase 7.5% 7.6% 5.0% 3.0% 3.7%
Net operating income increase (cash basis) 10.2% 7.3% 7.5% 7.1% 7.8%

(1)Refer to "Occupancy" in this Supplemental Information for additional details.
High-Quality, Diverse, and Innovative Tenants
June 30, 2022

Long-Duration Cash Flows From High-Quality, Diverse, and
Innovative Tenants

Investment-Grade or
Publicly Traded Large Cap Tenants
Industry Mix of 1,000+ Tenants
50%
of ARE's Total Annual Rental Revenue(1)
Long-Duration Lease Terms
7.1 Years
Weighted-Average Remaining Term(2)
Percentage of ARE's Annual Rental Revenue(1)
(1)Represents annual rental revenue in effect as of June 30, 2022.
(2)Based on aggregate annual rental revenue in effect as of June 30, 2022. Refer to "Annual rental revenue" in the "Definitions and reconciliations"of this Supplemental Information for additional details about our methodology on annual rental revenue from unconsolidated real estate joint ventures.
(3)Represents annual rental revenue currently generated from space that is targeted for a future change in use. The weighted-average remaining term of these leases is 4.2 years.
(4)Our other tenants, aggregating 4.0% of our annual rental revenue, comprise 3.0% of annual rental revenue from technology, professional services, finance, telecommunications, and construction/real estate companies and only 1.0% from retail-related tenants.
Class A Properties in AAA Locations
June 30, 2022
High-Quality Cash Flows From High-Quality Tenants and
Class A Properties in AAA Locations

Industry-Leading
Tenant Roster
AAA Locations
86%
of ARE's Top 20 Tenants
Annual Rental Revenue(1)
Is From Investment-Grade
or Publicly Traded Large Cap Tenants
Percentage of ARE's Annual Rental Revenue(2)

(1)As of June 30, 2022. Represents the percentage of our annual rental revenue generated by our top 20 tenants that are also investment-grade or publicly traded large cap tenants.
(2)Represents annual rental revenue in effect as of June 30, 2022.
Occupancy
June 30, 2022
Solid Historical Occupancy(1)
Occupancy Across Key Locations
96%
Over 10 Years

(1)Represents average occupancy of operating properties in North America as of each December 31 for the last 10 years and as of June 30, 2022.
(2)Excludes 1.6 million RSF, or 3.8%, of vacancy at recently acquired properties (noted below) representing lease-up opportunities that are expected to generate incremental annual rental revenue. Approximately 34% of the vacant 1.6 million RSF is currently leased/negotiating. Additionally, approximately 23% of the vacant 1.6 million RSF represents spaces, spread across multiple recently acquired properties, that are expected to be converted to laboratory/office space in the future. We expect to deliver 19% of the 1.6 million RSF over the next two quarters. Excluding recently acquired vacancies, occupancy of operating properties in North America was 98.4% as of June 30, 2022. The following table provides vacancy detail for our recent acquisitions:
As of June 30, 2022
Percentage of Vacancy Leased/Negotiating RSF
Vacant
RSF
Operating Properties Occupancy Impact
Property Market/Submarket Region North America
Intersection Campus Texas/Austin 159,638 9.6 % 0.4 % 100 %
601 and 611 Gateway Boulevard San Francisco Bay Area/South San Francisco 153,596 1.8 % 0.4 46
Alexandria Center® for Life Science - Durham
Research Triangle/Research Triangle 128,387 3.6 % 0.3 53
275 Grove Street Greater Boston/Route 128 124,240 1.2 % 0.3 -
(3)
Alexandria Center® for Life Science - Fenway
Greater Boston/Fenway 89,458 0.8 % 0.2 20
Other acquisitions Various 909,833 N/A 2.2 24
1,565,152 3.8 % 34 %
(3)We are evaluating options to develop or redevelop this space for laboratory space in the future.
Key Operating Metrics
June 30, 2022
Historical Same Property
Net Operating Income Growth
Favorable Lease Structure(1)
Strategic Lease Structure by Owner and Operator of Collaborative
Life Science, Agtech, and Technology Campuses
Increasing cash flows
Percentage of leases containing
annual rent escalations
97%
Stable cash flows
Percentage of triple
net leases
91%
Lower capex burden
Percentage of leases providing for the
recapture of capital expenditures
94%
Historical Rental Rate Growth:
Renewed/Re-Leased Space
Margins(2)
Operating Adjusted EBITDA
70% 70%
(1)Percentages calculated based on annual rental revenue as of June 30, 2022.
(2)Represents percentages for the three months ended June 30, 2022.
Same Property Performance
June 30, 2022
(Dollars in thousands)
June 30, 2022 June 30, 2022
Same Property Financial Data
Three Months Ended Six Months Ended
Same Property Statistical Data
Three Months Ended Six Months Ended
Percentage change over comparable period from prior year:
Number of same properties
287 266
Net operating income increase
7.5% 7.7%
Rentable square feet
28,897,189 27,008,468
Net operating income increase (cash basis)
10.2% 8.6%
Occupancy - current-period average
95.9% 95.8%
Operating margin
71% 71%
Occupancy - same-period prior-year average
94.5% 94.6%

Three Months Ended June 30, Six Months Ended June 30,
2022 2021 $ Change % Change 2022 2021 $ Change % Change
Income from rentals:
Same properties $ 378,130 $ 350,577 $ 27,553 7.9 % $ 708,840 $ 656,182 $ 52,658 8.0 %
Non-same properties 106,937 46,227 60,710 131.3 245,764 110,855 134,909 121.7
Rental revenues 485,067 396,804 88,263 22.2 954,604 767,037 187,567 24.5
Same properties 124,693 101,088 23,605 23.4 235,108 196,835 38,273 19.4
Non-same properties 31,199 10,479 20,720 197.7 63,801 23,194 40,607 175.1
Tenant recoveries 155,892 111,567 44,325 39.7 298,909 220,029 78,880 35.8
Income from rentals 640,959 508,371 132,588 26.1 1,253,513 987,066 266,447 27.0
Same properties 193 134 59 44.0 324 209 115 55.0
Non-same properties 2,612 1,114 1,498 134.5 4,992 2,193 2,799 127.6
Other income 2,805 1,248 1,557 124.8 5,316 2,402 2,914 121.3
Same properties 503,016 451,799 51,217 11.3 944,272 853,226 91,046 10.7
Non-same properties 140,748 57,820 82,928 143.4 314,557 136,242 178,315 130.9
Total revenues 643,764 509,619 134,145 26.3 1,258,829 989,468 269,361 27.2
Same properties 147,045 120,686 26,359 21.8 271,903 228,963 42,940 18.8
Non-same properties 49,239 23,269 25,970 111.6 105,709 52,880 52,829 99.9
Rental operations 196,284 143,955 52,329 36.4 377,612 281,843 95,769 34.0
Same properties 355,971 331,113 24,858 7.5 672,369 624,263 48,106 7.7
Non-same properties 91,509 34,551 56,958 164.9 208,848 83,362 125,486 150.5
Net operating income $ 447,480 $ 365,664 $ 81,816 22.4 % $ 881,217 $ 707,625 $ 173,592 24.5 %
Net operating income - same properties
$ 355,971 $ 331,113 $ 24,858 7.5 % $ 672,369 $ 624,263 $ 48,106 7.7 %
Straight-line rent revenue (15,859) (22,214) 6,355 (28.6) (41,101) (41,360) 259 (0.6)
Amortization of acquired below-market leases (9,875) (9,338) (537) 5.8 (14,063) (14,365) 302 (2.1)
Net operating income - same properties (cash basis)
$ 330,237 $ 299,561 $ 30,676 10.2 % $ 617,205 $ 568,538 $ 48,667 8.6 %

Refer to "Same property comparisons" in the "Definitions and reconciliations" of this Supplemental Information for a reconciliation of same properties to total properties. "Definitions and reconciliations" also contains definitions of "Tenant recoveries" and "Net operating income" and their respective reconciliations from the most directly comparable financial measures presented in accordance with GAAP.
Leasing Activity
June 30, 2022
(Dollars per RSF)
Three Months Ended Six Months Ended Year Ended
June 30, 2022 June 30, 2022 December 31, 2021
Including
Straight-Line Rent
Cash Basis Including
Straight-Line Rent
Cash Basis Including
Straight-Line Rent
Cash Basis
Leasing activity:
Renewed/re-leased space(1)
Rental rate changes
45.4%
(2)
33.9%
(2)
39.0% 25.2% 37.9% 22.6%
New rates
$54.34 $52.31 $56.61 $54.47 $59.00 $55.60
Expiring rates
$37.36 $39.07 $40.73 $43.50 $42.80 $45.36
RSF
1,087,082 1,951,159 4,614,040
Tenant improvements/leasing commissions
$22.54 $26.83 $41.05
Weighted-average lease term
5.2 years 4.8 years 6.3 years
Developed/redeveloped/previously vacant space leased(3)
New rates
$76.69 $68.39 $79.72 $70.20 $78.52 $69.42
RSF
1,192,676 2,792,037 4,902,261
Weighted-average lease term
12.7 years 12.9 years 11.2 years
Leasing activity summary (totals):
New rates
$66.03 $60.72 $70.21 $63.73 $69.05 $62.72
RSF
2,279,758 4,743,196
(4)
9,516,301
Weighted-average lease term
9.1 years 9.5 years 8.8 years
Lease expirations(1)
Expiring rates
$34.82 $36.26 $38.15 $38.30 $41.53 $43.70
RSF 1,572,185 3,094,767 5,747,192

Leasing activity includes 100% of results for each property in which we have an investment in North America.

(1)Excludes month-to-month leases aggregating 210,038 RSF and 110,180 RSF as of June 30, 2022 and December 31, 2021, respectively.
(2)For 2Q22, rental rate increases of 45.4% and 33.9% (cash basis) represent the second-highest and the highest quarterly increases in Company history, respectively.
(3)Refer to "New Class A development and redevelopment properties: summary of pipeline" of this Supplemental Information for additional details on total project costs.
(4)During the six months ended June 30, 2022, we granted tenant concessions/free rent averaging 2.8 months with respect to the 4,743,196 RSF leased. Approximately 58% of the leases executed during the six months ended June 30, 2022 did not include concessions for free rent.
Contractual Lease Expirations
June 30, 2022
Year RSF Percentage of
Occupied RSF
Annual Rental Revenue (per RSF)(1)
Percentage of Total
Annual Rental Revenue
2022
(2)
987,720 2.6 % $ 51.62 2.6 %
2023 3,897,615 10.1 % $ 44.39 9.0 %
2024 3,444,777 8.9 % $ 45.38 8.1 %
2025 3,488,483 9.0 % $ 48.77 8.8 %
2026 2,515,497 6.5 % $ 50.94 6.6 %
2027 2,671,591 6.9 % $ 53.50 7.4 %
2028 3,782,340 9.8 % $ 49.10 9.6 %
2029 2,345,066 6.1 % $ 58.28 7.1 %
2030 2,486,008 6.4 % $ 56.28 7.3 %
2031 3,034,985 7.9 % $ 52.91 8.3 %
Thereafter 9,987,771 25.8 % $ 48.39 25.2 %

Market
2022 Contractual Lease Expirations (in RSF)
Annual Rental Revenue
(per RSF)(1)
2023 Contractual Lease Expirations (in RSF)
Annual Rental Revenue
(per RSF)(1)
Leased Negotiating/
Anticipating
Targeted for
Development/
Redevelopment(3)
Remaining
Expiring
Leases(4)
Total(2)
Leased Negotiating/
Anticipating
Targeted for
Development/
Redevelopment(3)
Remaining
Expiring Leases
Total
Greater Boston 36,379 - 48,793 118,677 203,849 $ 75.06 110,943

80,506 323,110

637,785 1,152,344 $ 57.53
San Francisco Bay Area - 74,992 - 60,622 135,614 44.87 15,711 160,622 250,000

338,410 764,743 59.11
New York City - - - 24,303 24,303 N/A - - - 85,055 85,055 N/A
San Diego 165,146 - 34,715 91,376

291,237 47.45 6,619 10,563

269,048 699,206 985,436 26.62
Seattle - 7,566 50,552 41,087 99,205 13.67 - - 110,885 266,752 377,637 25.19
Maryland 34,001 21,241 - 59,988 115,230 22.95 - 74,054 -

218,233 292,287 28.18
Research Triangle - - - 30,855 30,855 35.48 - 81,956 - 126,941 208,897 32.40
Texas 65,188 - - - 65,188 24.89 - - - - - -
Canada - 14,590 - - 14,590 34.66 - 13,321 - - 13,321 29.99
Non-cluster/other markets - - - 7,649 7,649 82.26 - - - 17,895 17,895 68.01
Total 300,714 118,389 134,060 434,557 987,720 $ 51.62 133,273 421,022 953,043 2,390,277

3,897,615 $ 44.39
Percentage of expiring leases
30 % 12 % 14 % 44 % 100 % 3 % 11 % 24 % 62 % 100 %

(1)Represents amounts in effect as of June 30, 2022.
(2)Excludes month-to-month leases aggregating 210,038 RSF as of June 30, 2022.
(3)Represents RSF targeted for development or redevelopment upon expiration of existing in-place leases primarily related to recently acquired properties with an average contractual lease expiration date of September 29, 2022 and January 30, 2023 for 2022 and 2023, respectively, weighted by annual rental revenue. Refer to "Investments in real estate" in the "Definitions and reconciliations" of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.
(4)The largest remaining contractual expiration is 73,273 RSF in our Cambridge/Inner Suburbs submarket.
Top 20 Tenants
June 30, 2022
(Dollars in thousands, except average market cap amounts)
86% of Top 20 Annual Rental Revenue From Investment-Grade
or Publicly Traded Large Cap Tenants(1)

Tenant
Remaining Lease Term(1) (in years)
Aggregate
RSF
Annual Rental Revenue(1)
Percentage of Aggregate Annual Rental Revenue(1)
Investment-Grade
Credit Ratings
Average Market Cap(1)
(in billions)
Moody's S&P
1 Bristol-Myers Squibb Company 6.4 919,292 $ 67,575 3.5 % A2 A+ $ 146.4
2 Eli Lilly and Company 7.0 733,781 48,836 2.5 A2 A+ $ 252.5
3 Moderna, Inc. 15.1 878,933 48,777 2.5 - - $ 98.2
4 Sanofi 6.3 490,154 42,284 2.2 A1 AA $ 129.6
5 Takeda Pharmaceutical Company Limited 7.5 549,760 37,399 1.9 Baa2 BBB+ $ 47.3
6 Illumina, Inc. 8.1 891,495 36,196 1.9 Baa3 BBB $ 57.0
7
2seventy bio, Inc.(2)
11.2 312,805 33,617 1.7 - - $ 0.5
8 Novartis AG 6.1 447,831 30,582 1.6 A1 AA- $ 211.3
9 TIBCO Software Inc. 4.7
(3)
292,013 28,537 1.5 - - $ -
10 Uber Technologies, Inc. 60.2
(4)
1,009,188 27,677 1.4 - - $ 71.9
11 Roche 7.0 416,833 26,541 1.4 Aa3 AA $ 326.1
12 Merck & Co., Inc. 10.4 339,344 21,889 1.1 A1 A+ $ 204.3
13 Maxar Technologies 3.5
(5)
478,000 21,803 1.1 - - $ 2.2
14 Massachusetts Institute of Technology 6.5 257,626 21,165 1.1 Aaa AAA $ -
15 The Children's Hospital Corporation 14.3 269,816 20,066 1.0 Aa2 AA $ -
16 New York University 9.4 203,500 19,241 1.0 Aa2 AA- $ -
17 Pfizer Inc. 3.0 416,996 17,742 0.9 A2 A+ $ 276.2
18 Apple Inc. 2.9 604,382 17,512 0.9 Aaa AA+ $ 2,560.6
19 United States Government 7.6 315,908 17,491 0.9 Aaa AA+ $ -
20 Alphabet Inc. 4.7 354,304 16,985 0.9 Aa2 AA+ $ 1,775.6
Total/weighted-average
10.2
(4)
10,181,961 $ 601,915 31.0 %

(1)Based on aggregate annual rental revenue in effect as of June 30, 2022. Represents the percentage of our annual rental revenue generated by our top 20 tenants that are also investment-grade or publicly traded large cap tenants. Refer to "Annual rental revenue" and "Investment-grade or publicly traded large cap tenants" in the "Definitions and reconciliations"of this Supplemental Information for additional details about our methodology on annual rental revenue from unconsolidated real estate joint ventures and average market capitalization, respectively.
(2)Represents two leases in our Greater Boston and Seattle markets with in-place cash rents that are 5%-10% below current market. As of March 31, 2022, 2seventy bio, Inc. held $270.9 million of cash and cash equivalents.
(3)Represents the remaining lease term at four recently acquired properties with future redevelopment and development opportunities. The leases with this tenant were in place when we acquired the properties during the three months ended March 31, 2022.
(4)Includes (i) ground leases for land at 1455 and 1515 Third Street (two buildings aggregating 422,980 RSF) and (ii) leases at 1655 and 1725 Third Street (two buildings aggregating 586,208 RSF) owned by our unconsolidated real estate joint venture in which we have an ownership interest of 10%. Annual rental revenue is presented using 100% of the annual rental revenue from our consolidated properties and our share of annual rental revenue from our unconsolidated real estate joint ventures. Refer to footnote 1 for additional details. Excluding the ground leases, the weighted-average remaining lease term for our top 20 tenants was 7.8 years as of June 30, 2022.
(5)Represents the remaining lease term at two acquired properties with future redevelopment and development opportunities. The leases with this tenant were in place when we acquired the properties in 2019.
Summary of Properties and Occupancy
June 30, 2022
(Dollars in thousands, except per RSF amounts)

Summary of properties
Market
RSF Number of Properties Annual Rental Revenue
Operating Development Redevelopment Total % of Total Total % of Total Per RSF
Greater Boston
10,654,420 1,887,038 1,300,281 13,841,739 29 % 85 $ 661,389 34 % $ 65.33
San Francisco Bay Area 8,678,996 230,592 300,010 9,209,598 20 72 477,206 25 61.26
New York City
1,204,461 - 65,558 1,270,019 3 5 96,228 5 82.14
San Diego
8,000,319 229,094 - 8,229,413 18 102 331,296 17 42.98
Seattle
2,813,803 311,631 213,976 3,339,410 7 46 108,333 6 39.60
Maryland
3,427,753 282,000 122,856 3,832,609 8 50 111,204 6 33.79
Research Triangle
3,550,170 329,718 376,871 4,256,759 9 42 94,291 5 28.41
Texas 1,668,718 - 201,499 1,870,217 4 14 36,884 1 28.20
Canada
614,028 - - 614,028 1 7 11,190 - 23.74
Non-cluster/other markets 412,128 - - 412,128 1 12 14,415 1 45.58
Properties held for sale
58,733 - - 58,733 - 1 428 - N/A
North America 41,083,529 3,270,073 2,581,051 46,934,653 100 % 436 $ 1,942,864 100 % $ 50.80
5,851,124

Summary of occupancy
Operating Properties Operating and Redevelopment Properties
Market 6/30/22 3/31/22 6/30/21 6/30/22 3/31/22 6/30/21
Greater Boston 95.0 %
(1)
95.4 % 95.5 % 84.7 % 85.0 % 91.0 %
San Francisco Bay Area 95.8 95.6 94.0 92.6 92.4 92.9
New York City 97.3
(2)
98.4 99.4 92.2 91.9 90.1
San Diego 96.3 94.2 93.8 96.3 92.7 92.3
Seattle 97.2 97.9 97.6 90.4 91.0 90.2
Maryland 97.6
(3)
100.0 98.9 94.2 96.4 90.3
Research Triangle 93.5 93.6 92.8 84.5 85.5 84.1
Texas 78.4 N/A N/A 69.9 N/A N/A
Subtotal 95.1 95.7 95.2 89.3 89.8 90.9
Canada 76.8 76.5 77.0 76.8 76.5 77.0
Non-cluster/other markets 76.7 80.4 46.0 76.7 75.7 46.0
North America 94.6 %
(4)
94.7 % 94.3 % 89.0 % 88.9 % 90.1 %
(1)Decline in occupancy primarily related to temporary vacancy of 40,282 RSF at one property in our Cambridge submarket.
(2)Decline in occupancy related to temporary vacancy of 13,298 RSF at 450 E. 29th Street. This space is leased with occupancy to commence in 3Q22.
(3)Decline in occupancy primarily related to temporary vacancy at one property in our Alexandria Technology Center® - Gaithersburg II campus. This space is leased with occupancy to commence in 1Q23.
(4)Refer to "Occupancy" of this Supplemental Information for additional details on vacancy at recently acquired properties.

Property Listing
June 30, 2022
(Dollars in thousands)
Mega Campuses Encompass 66% of Our Operating Property RSF(1)
Market / Submarket / Address
RSF
Number of Properties Annual Rental Revenue
Occupancy Percentage
Operating Operating and Redevelopment
Operating Development Redevelopment Total
Greater Boston
Cambridge/Inner Suburbs
Mega Campus: Alexandria Center® at Kendall Square
2,369,854 - 403,892 2,773,746 11 $ 185,373 98.9 % 84.5 %
50(2), 60(2), 75/125(2), 100(2), and 225(2) Binney Street, 161 and 215 First Street, 150 Second Street, 300 Third Street(2), 11 Hurley Street, and One Rogers Street
Mega Campus: Alexandria Center® at One Kendall Square
903,777 462,100 - 1,365,877 12 83,028 97.7 97.7
One Kendall Square - Buildings 100, 200, 300, 400, 500, 600/700, 1400, 1800, and 2000, 325 and 399 Binney Street, and One Hampshire Street
Mega Campus: Alexandria Technology Square®
1,181,635 - - 1,181,635 7 114,427 100.0 100.0
100, 200, 300, 400, 500, 600, and 700 Technology Square
Mega Campus: The Arsenal on the Charles 772,557 248,018 100,108 1,120,683 13 44,134 94.8 84.0
311, 321, and 343 Arsenal Street, 300, 400, and 500 North Beacon Street,
1, 2, 3, and 4 Kingsbury Avenue, and 100, 200, and 400 Talcott Avenue
Mega Campus: 480 Arsenal Way and 500 and 550 Arsenal Street 495,127 - - 495,127 3 23,014 98.3 98.3
99 Coolidge Avenue(2)
- 320,809 - 320,809 1 - N/A N/A
640 Memorial Drive
225,504 - - 225,504 1 15,551 82.1 82.1
780 and 790 Memorial Drive 99,658 - - 99,658 2 9,168 100.0 100.0
167 Sidney Street and 99 Erie Street 54,549 - - 54,549 2 4,028 100.0 100.0
79/96 13th Street (Charlestown Navy Yard)
25,309 - - 25,309 1 797 100.0 100.0
Cambridge/Inner Suburbs
6,127,970 1,030,927 504,000 7,662,897 53 479,520 97.8 90.4
Fenway
Mega Campus: Alexandria Center® for Life Science - Fenway
927,499 510,116 - 1,437,615 2 59,172 90.4 90.4
401 Park Drive and 201 Brookline Avenue(2)
Seaport Innovation District
5 and 15(2) Necco Street
95,400 345,995 - 441,395 2 6,331 86.6 86.6
Mega Campus: 380 and 420 E Street 195,506 - - 195,506 2 4,472 100.0 100.0
Seaport Innovation District 290,906 345,995 - 636,901 4 10,803 95.6 95.6
Route 128
Mega Campus: One Upland Road, 100 Tech Drive, and One Investors Way 706,988 - - 706,988 4 29,059 100.0 100.0
19, 225, and 235 Presidential Way 585,022 - - 585,022 3 13,508 99.9 99.9
Reservoir Woods 312,845 - 202,428 515,273 3 15,469 100.0 60.7
40, 50, and 60 Sylvan Road
275 Grove Street
509,702 - - 509,702 3 17,253 75.6 75.6
225, 266, and 275 Second Avenue
329,005 - - 329,005 3 18,461 100.0 100.0
840 Winter Street 28,230 - 139,984 168,214 1 1,239 100.0 16.8
100 Beaver Street
82,330 - - 82,330 1 5,110 100.0 100.0
Route 128 2,554,122 - 342,412 2,896,534 18 100,099 95.1 83.9
Other 753,923 - 453,869 1,207,792 8 11,795 77.5 48.3
Greater Boston
10,654,420 1,887,038 1,300,281 13,841,739 85 $ 661,389 95.0 % 84.7 %

(1)Refer to "New Class A development and redevelopment properties: summary of pipeline" and to "Mega campus" in the "Definitions and reconciliations" of this Supplemental Information for additional details.
(2)We own a partial interest in this property through a real estate joint venture. Refer to "Joint venture financial information" of this Supplemental Information for additional details.
Property Listing (continued)
June 30, 2022
(Dollars in thousands)
Market / Submarket / Address
RSF
Number of Properties Annual Rental Revenue
Occupancy Percentage
Operating Operating and Redevelopment
Operating Development Redevelopment Total
San Francisco Bay Area
Mission Bay
Mega Campus: Alexandria Center® for Science and Technology -
Mission Bay(1)
2,015,177 - - 2,015,177 9 $ 96,014 99.9 % 99.9 %
1455(2), 1515(2), 1655, and 1725 Third Street, 409 and 499 Illinois Street, 1500 and 1700 Owens Street, and 455 Mission Bay Boulevard South
Mission Bay 2,015,177 - - 2,015,177 9 96,014 99.9 99.9
South San Francisco
Mega Campus: Alexandria Technology Center® - Gateway(1)
1,114,890 230,592 300,010 1,645,492 12 53,869 85.0 67.0
600(2), 601, 611, 630(2), 650(2), 651, 681, 685, 701, 751, 901(2), and 951(2)
Gateway Boulevard
Mega Campus: 213(1), 249, 259, 269, and 279 East Grand Avenue
919,704 - - 919,704 5 48,951 100.0 100.0
Mega Campus: 1122 and 1150 El Camino Real 725,172 - - 725,172 2 13,081 97.6 97.6
Alexandria Center® for Life Science - South San Francisco
504,551 - - 504,551 3 36,750 100.0 100.0
201 Haskins Way and 400 and 450 East Jamie Court
500 Forbes Boulevard(1)
155,685 - - 155,685 1 10,680 100.0 100.0
7000 Shoreline Court
139,709 - - 139,709 1 8,657 100.0 100.0
341 and 343 Oyster Point Boulevard
108,208 - - 108,208 2 6,788 100.0 100.0
849/863 Mitten Road/866 Malcolm Road
103,857 - - 103,857 1 4,829 100.0 100.0
South San Francisco 3,771,776 230,592 300,010 4,302,378 27 183,605 95.1 88.1
Greater Stanford
Mega Campus: Alexandria Center® for Life Science - San Carlos
739,192 - - 739,192 9 49,745 95.3 95.3
825, 835, 960, and 1501-1599 Industrial Road
Alexandria Stanford Life Science District
703,742 - - 703,742 9 63,683 98.9 98.9
3160, 3165, 3170, and 3181 Porter Drive and 3301, 3303, 3305, 3307, and 3330 Hillview Avenue
3825 and 3875 Fabian Way
478,000 - - 478,000 2 21,802 100.0 100.0
3412, 3420, 3440, 3450, and 3460 Hillview Avenue 338,751 - - 338,751 5 21,133 73.8 73.8
2100, 2200, 2300, and 2400 Geng Road 194,648 - - 194,648 4 9,302 79.2 79.2
2475 and 2625/2627/2631 Hanover Street and 1450 Page Mill Road 194,503 - - 194,503 3 18,012 100.0 100.0
2425 Garcia Avenue/2400/2450 Bayshore Parkway
99,208 - - 99,208 1 4,257 100.0 100.0
Shoreway Science Center
82,462 - - 82,462 2 5,322 100.0 100.0
75 and 125 Shoreway Road
3350 West Bayshore Road
61,537 - - 61,537 1 4,331 93.7 93.7
Greater Stanford 2,892,043 - - 2,892,043 36 197,587 93.9 93.9
San Francisco Bay Area 8,678,996 230,592 300,010 9,209,598 72 $ 477,206 95.8 % 92.6 %

Refer to "New Class A development and redevelopment properties: summary of pipeline" and to "Mega campus" in the "Definitions and reconciliations" of this Supplemental Information for additional details.

(1)We own a partial interest in this property through a real estate joint venture. Refer to "Joint venture financial information" of this Supplemental Information for additional details.
(2)We own 100% of this property.
Property Listing (continued)
June 30, 2022
(Dollars in thousands)
Market / Submarket / Address
RSF
Number of Properties Annual Rental Revenue
Occupancy Percentage
Operating Operating and Redevelopment
Operating Development Redevelopment Total
New York City
New York City
Mega Campus: Alexandria Center® for Life Science - New York City
740,972 - - 740,972 3 $ 75,933 95.5 % 95.5 %
430 and 450 East 29th Street
219 East 42nd Street
349,947 - - 349,947 1 14,006 100.0 100.0
Alexandria Center® for Life Science - Long Island City
113,542 - 65,558 179,100 1 6,289 100.0 63.4
30-02 48th Avenue
New York City
1,204,461 - 65,558 1,270,019 5 96,228 97.3 92.2
San Diego
Torrey Pines
Mega Campus: One Alexandria Square and One Alexandria North
904,883 - - 904,883 10 52,801 97.8 97.8
3115 and 3215 Merryfield Row, 3010, 3013, and 3033 Science Park Road, 10975 and 11119 North Torrey Pines Road, 10975, 10995, and 10996 Torreyana Road, and 3545 Cray Court
ARE Torrey Ridge
298,863 - - 298,863 3 15,688 100.0 100.0
10578, 10618, and 10628 Science Center Drive
ARE Nautilus
213,900 - - 213,900 4 12,352 88.1 88.1
3530 and 3550 John Hopkins Court and 3535 and 3565 General Atomics Court
Torrey Pines 1,417,646 - - 1,417,646 17 80,841 96.8 96.8
University Town Center
Mega Campus: Alexandria Point(1)
1,436,198 - - 1,436,198 8 69,937 97.3 97.3
9880(2), 10210, 10260, 10290, and 10300 Campus Point Drive and 4161, 4224, and 4242Campus Point Court
Mega Campus: 5200 Illumina Way(1)
792,687 - - 792,687 6 29,978 100.0 100.0
Mega Campus: University District 415,462 - - 415,462 7 18,709 100.0 100.0
9625 Towne Centre Drive(1), 4755, 4757, and 4767 Nexus Center Drive, 4796 Executive Drive, 8505 Costa Verde Boulevard, and 4260 Nobel Drive
University Town Center 2,644,347 - - 2,644,347 21 118,624 98.5 98.5
Sorrento Mesa
Mega Campus: SD Tech by Alexandria(1)
976,842 84,981 - 1,061,823 14 37,866 93.4 93.4
9605, 9645, 9675, 9685, 9725, 9735, 9808, 9855, and 9868 Scranton Road, 5505 Morehouse Drive(2), and 10055, 10065, 10121(2), and 10151(2) Barnes Canyon Road
Mega Campus: Sequence District by Alexandria 805,223 - - 805,223 7 34,183 100.0 100.0
6260, 6290, 6310, 6340, 6350, 6420, and 6450 Sequence Drive
Pacific Technology Park(1)
572,887 - - 572,887 6 8,926 96.0 96.0
9389, 9393, 9401, 9444, 9455, and 9477 Waples Street
Summers Ridge Science Park
316,531 - - 316,531 4 $ 11,077 100.0 % 100.0 %
9965, 9975, 9985, and 9995 Summers Ridge Road

Refer to "New Class A development and redevelopment properties: summary of pipeline" and to "Mega campus" in the "Definitions and reconciliations" of this Supplemental Information for additional details.

(1)We own a partial interest in this property through a real estate joint venture. Refer to "Joint venture financial information" of this Supplemental Information for additional details.
(2)We own 100% of this property.
Property Listing (continued)
June 30, 2022
(Dollars in thousands)
Market / Submarket / Address
RSF
Number of Properties Annual Rental Revenue
Occupancy Percentage
Operating Operating and Redevelopment
Operating Development Redevelopment Total
San Diego (continued)
Sorrento Mesa (continued)
Scripps Science Park by Alexandria 99,970 144,113 - 244,083 3 $ 2,498 100.0 % 100.0 %
10102 Hoyt Park Drive and 10256 and 10260 Meanley Drive
ARE Portola
101,857 - - 101,857 3 3,603 100.0 100.0
6175, 6225, and 6275 Nancy Ridge Drive
7330 and 7360 Carroll Road
84,442 - - 84,442 2 3,247 100.0 100.0
5810/5820 Nancy Ridge Drive
83,354 - - 83,354 1 3,853 100.0 100.0
9877 Waples Street 63,774 - - 63,774 1 2,374 100.0 100.0
5871 Oberlin Drive
33,842 - - 33,842 1 1,772 100.0 100.0
Sorrento Mesa 3,138,722 229,094 - 3,367,816 42 109,399 97.2 97.2
Sorrento Valley
3911, 3931, 3985, 4025, and 4045 Sorrento Valley Boulevard 131,698 - - 131,698 5 5,051 84.0 84.0
11025, 11035, 11045, 11055, 11065, and 11075 Roselle Street
119,513 - - 119,513 6 3,853 95.0 95.0
Sorrento Valley 251,211 - - 251,211 11 8,904 89.3 89.3
Other 548,393 - - 548,393 11 13,528 82.8 82.8
San Diego
8,000,319 229,094 - 8,229,413 102 331,296 96.3 96.3
Seattle
Lake Union
Mega Campus: The Eastlake Life Science Campus by Alexandria 937,290 311,631 - 1,248,921 9 56,410 97.8 97.8
1150, 1165, 1201(1), 1208(1), 1551, and 1616 Eastlake Avenue East, 188 and 199(1) East Blaine Street, and 1600 Fairview Avenue East
Mega Campus: Alexandria Center® for Life Science - South Lake Union
400(1) and 601 Dexter Avenue North
308,791 - - 308,791 2 15,380 100.0 100.0
219 Terry Avenue North
30,705 - - 30,705 1 1,855 100.0 100.0
Lake Union 1,276,786 311,631 - 1,588,417 12 73,645 98.4 98.4
SoDo
830 4th Avenue South 42,380 - - 42,380 1 1,628 70.5 70.5
Elliott Bay
3000/3018 Western Avenue
47,746 - - 47,746 1 3,147 100.0 100.0
410 West Harrison Street and 410 Elliott Avenue West
36,849 - - 36,849 2 1,570 100.0 100.0
Elliott Bay 84,595 - - 84,595 3 $ 4,717 100.0 % 100.0 %

Refer to "New Class A development and redevelopment properties: summary of pipeline" and to "Mega campus" in the "Definitions and reconciliations" of this Supplemental Information for additional details.

(1)We own a partial interest in this property through a real estate joint venture. Refer to "Joint venture financial information" of this Supplemental Information for additional details.
Property Listing (continued)
June 30, 2022
(Dollars in thousands)
Market / Submarket / Address
RSF
Number of Properties Annual Rental Revenue
Occupancy Percentage
Operating Operating and Redevelopment
Operating Development Redevelopment Total
Seattle (continued)
Bothell
Mega Campus: Alexandria Center® for Advanced Technologies - Canyon Park
1,060,958 - - 1,060,958 22 $ 22,634 97.4 % 97.4 %
22121 and 22125 17th Avenue Southeast, 22021, 22025, 22026, 22030, 22118, and 22122 20th Avenue Southeast, 22333, 22422, 22515, 22522, 22722, and 22745 29th Drive Southeast, 21540, 22213, and 22309 30th Drive Southeast, and 1629, 1631, 1725, 1916, and 1930 220th Street Southeast
Alexandria Center® for Advanced Technologies - Monte Villa Parkway
246,647 - 213,976 460,623 6 4,645 97.3 52.1
3301, 3303, 3305, 3307, 3555, and 3755 Monte Villa Parkway
Bothell 1,307,605 - 213,976 1,521,581 28 27,279 97.4 83.7
Other 102,437 - - 102,437 2 1,064 90.0 90.0
Seattle
2,813,803 311,631 213,976 3,339,410 46 108,333 97.2 90.4
Maryland
Rockville
Mega Campus: Alexandria Center® for Life Science - Shady Grove
1,072,891 282,000 78,533 1,433,424 19 45,645 98.3 91.6
9601, 9603, 9605, 9704, 9708, 9712, 9714, 9800, 9804, 9808, 9900, and 9950 Medical Center Drive, 14920 and 15010 Broschart Road, 9920 Belward Campus Drive, and 9810 Darnestown Road
1330 Piccard Drive
131,511 - - 131,511 1 4,021 100.0 100.0
1405 and 1450(1) Research Boulevard
114,849 - - 114,849 2 2,497 62.8 62.8
1500 and 1550 East Gude Drive
91,359 - - 91,359 2 1,844 100.0 100.0
5 Research Place
63,852 - - 63,852 1 2,992 100.0 100.0
5 Research Court
51,520 - - 51,520 1 1,788 100.0 100.0
12301 Parklawn Drive
49,185 - - 49,185 1 1,530 100.0 100.0
Rockville 1,575,167 282,000 78,533 1,935,700 27 60,317 96.2 91.6
Gaithersburg
Alexandria Technology Center® - Gaithersburg I
613,438 - - 613,438 9 17,844 100.0 100.0
9, 25, 35, 45, 50, and 55 West Watkins Mill Road and 910, 930, and 940 Clopper Road
Alexandria Technology Center® - Gaithersburg II
486,324 - - 486,324 7 17,557 96.5 96.5
700, 704, and 708 Quince Orchard Road and 19, 20, 21, and 22 Firstfield Road
20400 Century Boulevard 36,227 - 44,323 80,550 1 1,400 100.0 45.0
401 Professional Drive
63,154 - - 63,154 1 1,903 100.0 100.0
950 Wind River Lane
50,000 - - 50,000 1 1,004 100.0 100.0
620 Professional Drive
27,950 - - 27,950 1 1,207 100.0 100.0
Gaithersburg 1,277,093 - 44,323 1,321,416 20 40,915 98.7 95.4
Beltsville
8000/9000/10000 Virginia Manor Road 191,884 - - 191,884 1 2,865 100.0 100.0
101 West Dickman Street(1)
135,423 - - 135,423 1 980 96.7 96.7
Beltsville 327,307 - - 327,307 2 $ 3,845 98.6 % 98.6 %

Refer to "New Class A development and redevelopment properties: summary of pipeline" and to "Mega campus" in the "Definitions and reconciliations" of this Supplemental Information for additional details.

(1)We own a partial interest in this property through a real estate joint venture. Refer to "Joint venture financial information" of this Supplemental Information for additional details.
Property Listing (continued)
June 30, 2022
(Dollars in thousands)
Market / Submarket / Address
RSF
Number of Properties Annual Rental Revenue
Occupancy Percentage
Operating Operating and Redevelopment
Operating Development Redevelopment Total
Maryland (continued)
Northern Virginia
14225 Newbrook Drive 248,186 - - 248,186 1 $ 6,127 100.0 % 100.0 %
Maryland
3,427,753 282,000 122,856 3,832,609 50 111,204 97.6 94.2
Research Triangle
Research Triangle
Mega Campus: Alexandria Center® for Life Science - Durham
1,880,185 - 376,871 2,257,056 16 37,636 93.2 77.6
6, 8, 10, 12, 14, 40, 41, 42, and 65 Moore Drive, 21, 25, 27, 29, and 31
Alexandria Way, 2400 Ellis Road, and 14 TW Alexander Drive
Mega Campus: Alexandria Center® for Advanced Technologies
367,240 180,000 - 547,240 5 14,179 87.3 87.3
4, 6, 8, 10, and 12 Davis Drive
Alexandria Center® for AgTech
279,099 61,680 - 340,779 2 12,443 98.7 98.7
5 and 9 Laboratory Drive
104 and 108/110/112/114 TW Alexander Drive 227,902 - - 227,902 5 7,508 96.7 96.7
Alexandria Technology Center® - Alston
186,870 - - 186,870 3 4,227 90.8 90.8
100, 800, and 801 Capitola Drive
6040 George Watts Hill Drive 61,547 88,038 - 149,585 2 2,148 100.0 100.0
Alexandria Innovation Center® - Research Triangle
136,729 - - 136,729 3 4,398 94.3 94.3
7010, 7020, and 7030 Kit Creek Road
7 Triangle Drive
104,531 - - 104,531 1 3,479 100.0 100.0
2525 East NC Highway 54
82,996 - - 82,996 1 3,651 100.0 100.0
407 Davis Drive
81,956 - - 81,956 1 1,644 100.0 100.0
601 Keystone Park Drive
77,395 - - 77,395 1 1,072 74.3 74.3
5 Triangle Drive
32,120 - - 32,120 1 1,147 100.0 100.0
6101 Quadrangle Drive
31,600 - - 31,600 1 759 100.0 100.0
Research Triangle
3,550,170 329,718 376,871 4,256,759 42 94,291 93.5 84.5
Texas
Austin
Mega Campus: Intersection Campus 1,525,613 - - 1,525,613 12 36,884 85.7 85.7
Greater Houston
8800 Technology Forest Place - - 201,499 201,499 1 - N/A -
Other 143,105 - - 143,105 1 - - -
Greater Houston 143,105 - 201,499 344,604 2 - - -
Texas 1,668,718 - 201,499 1,870,217 14 36,884 78.4 69.9
Canada
614,028 - - 614,028 7 11,190 76.8 76.8
Non-cluster/other markets 412,128 - - 412,128 12 14,415 76.7 76.7
North America, excluding properties held for sale 41,024,796 3,270,073 2,581,051 46,875,920 435 1,942,436 94.6 % 89.0 %
Properties held for sale
58,733 - - 58,733 1 428 100.0 % 100.0 %
Total - North America
41,083,529 3,270,073 2,581,051 46,934,653 436 $ 1,942,864

Refer to "New Class A development and redevelopment properties: summary of pipeline" and to "Mega campus" in the "Definitions and reconciliations" of this Supplemental Information for additional details.

Investments in Real Estate
June 30, 2022

Demand for our value-creation development and redevelopment projects consisting of high-quality office/laboratory space, and for our continued operational excellence at our world-class and sophisticated laboratory facilities, has translated into record leasing activity.

Projects Either Under Construction or
Expected to Commence Construction in the Next Six Quarters(1)
>$665 Million
Projected Incremental Annual Rental Revenue
Primarily Commencing From 3Q22 Through 2Q25
7.8 million RSF(2)
78% Leased/Negotiating

As of June 30, 2022.

(1)We may also commence additional projects in this time frame, subject to market conditions.
(2)Includes 5.9 million RSF under construction that is 75% leased/negotiating and 2.0 million RSF expected to commence construction in the next six quarters that is 89% leased/negotiating.
Investments in Real Estate
June 30, 2022
(Dollars in thousands)

Development and Redevelopment
Operating Under Construction Near
Term
Intermediate
Term
Future Subtotal Total
Investments in real estate
Gross book value as of June 30, 2022(1)
$ 24,153,058 $ 3,746,801 $ 1,578,141 $ 687,091 $ 1,831,371 $ 7,843,404 $ 31,996,462
Square footage
Operating 41,083,529 - - - - - 41,083,529
New Class A development and redevelopment properties - 5,851,124 6,984,447
(2)
3,920,041 20,419,252 37,174,864 37,174,864
Value-creation square feet currently included in rental properties(3)
- - (944,983) (28,535) (3,197,239) (4,170,757) (4,170,757)
Total square footage
41,083,529 5,851,124 6,039,464 3,891,506 17,222,013 33,004,107 74,087,636

(1)Balances exclude accumulated depreciation and our share of the cost basis associated with our properties held by our unconsolidated real estate joint ventures, which is classified as investments in unconsolidated real estate joint ventures in our consolidated balance sheets. Refer to "Investments in real estate" in the "Definitions and reconciliations"of this Supplemental Information for reconciliation detail of investments in real estate.
(2)Includes 2.0 million RSF currently 89% leased/negotiating and expected to commence construction in the next six quarters. Refer to "New Class A development and redevelopment properties: current projects" for additional details.
(3)Refer to "Investments in real estate" in the "Definitions and reconciliations"of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.
New Class A Development and Redevelopment Properties: Recent Deliveries
June 30, 2022
The Arsenal on the Charles 201 Haskins Way 825 and 835 Industrial Road 3160 Porter Drive
Greater Boston/
Cambridge/Inner Suburbs
San Francisco Bay Area/
South San Francisco
San Francisco Bay Area/
Greater Stanford
San Francisco Bay Area/
Greater Stanford
287,570 RSF 323,190 RSF 526,129 RSF 92,300 RSF
100% Occupancy 100% Occupancy 100% Occupancy 83% Occupancy
30-02 48th Avenue 3115 Merryfield Row 10055 Barnes Canyon Road 5505 Morehouse Drive
New York City/New York City San Diego/Torrey Pines San Diego/Sorrento Mesa San Diego/Sorrento Mesa
71,629 RSF 146,456 RSF 110,454 RSF 79,945 RSF
100% Occupancy 93% Occupancy 100% Occupancy 100% Occupancy

New Class A Development and Redevelopment Properties: Recent Deliveries (continued)
June 30, 2022
9601 and 9603 Medical Center Drive 9950 Medical Center Drive 20400 Century Boulevard
Maryland/Rockville Maryland/Rockville Maryland/Gaithersburg
17,378 RSF 84,264 RSF 36,227 RSF
100% Occupancy 100% Occupancy 100% Occupancy
2400 Ellis Road, 40 and 41 Moore Drive, and
14 TW Alexander Drive(1)
5 and 9 Laboratory Drive(2)
8 and 10 Davis Drive(3)
Research Triangle/Research Triangle Research Triangle/Research Triangle Research Triangle/Research Triangle
326,445 RSF 278,720 RSF 250,000 RSF
100% Occupancy 100% Occupancy 94% Occupancy
(1)Image represents 2400 Ellis Road in our Alexandria Center® for Life Science - Durham mega campus.
(2)Image represents 9 Laboratory Drive in our Alexandria Center® for AgTech campus.
(3)Image represents 10 Davis Drive in our Alexandria Center® for Advanced Technologies mega campus.
New Class A Development and Redevelopment Properties: Recent Deliveries (continued)
June 30, 2022
(Dollars in thousands)

Property/Market/Submarket Our Ownership Interest RSF Placed in Service
Occupancy Percentage(3)
Total Project Unlevered Yields
2Q22 Delivery Date(1)
Prior to 1/1/22 1Q22
2Q22(2)
Total Initial Stabilized Initial Stabilized (Cash Basis)
RSF Investment
Development projects
201 Haskins Way/San Francisco Bay Area/South San Francisco N/A 100% 270,879 52,311 - 323,190 100% 323,190 $ 367,000 6.3 % 6.0 %
825 and 835 Industrial Road/San Francisco Bay Area/Greater Stanford N/A 100% 476,211 49,918 - 526,129 100% 526,129 631,000 6.7 6.5
3115 Merryfield Row/San Diego/Torrey Pines N/A 100% - 146,456 - 146,456 93% 146,456 150,000 6.3 6.2
10055 Barnes Canyon Road/San Diego/Sorrento Mesa 5/11/22 50% - - 110,454 110,454 100% 195,435 181,000 7.2 6.6
9950 Medical Center Drive/Maryland/Rockville N/A 100% - 84,264 - 84,264 100% 84,264 57,000 8.9 7.8
5 and 9 Laboratory Drive/Research Triangle/Research Triangle N/A 100% 267,509 11,211 - 278,720 100% 340,400 216,000 7.2 7.1
8 and 10 Davis Drive/Research Triangle/Research Triangle 6/21/22 100% 65,247 44,980 139,773 250,000 94% 250,000 159,000 7.6 7.3
Redevelopment projects
The Arsenal on the Charles/Greater Boston/Cambridge/Inner Suburbs 5/7/22 100% 137,111 99,796 50,663 287,570 100% 872,665 831,000 6.3 5.5
3160 Porter Drive/San Francisco Bay Area/Greater Stanford N/A 100% 57,696 34,604 - 92,300 83% 92,300 117,000 4.6 4.6
30-02 48th Avenue/New York City/New York City 5/16/22 100% 41,848 11,092 18,689 71,629 100% 179,100 224,000 5.8 5.8
5505 Morehouse Drive/San Diego/Sorrento Mesa 4/27/22 100% 28,324 - 51,621 79,945 100% 79,945 68,000 7.1 7.2
9601 and 9603 Medical Center Drive/Maryland/Rockville N/A 100% 17,378 - - 17,378 100% 95,911 54,000 8.4 7.1
20400 Century Boulevard/Maryland/Gaithersburg 6/1/22 100% - 32,033 4,194 36,227 100% 80,550 35,000 8.5 8.6
2400 Ellis Road, 40 and 41 Moore Drive, and 14 TW Alexander Drive/Research Triangle/Research Triangle N/A 100% 326,445 - - 326,445 100% 703,316 337,000 7.5 6.7
Total 5/18/22 1,688,648 566,665 375,394 2,630,707 3,969,661 $ 3,427,000 6.7 % 6.2 %

Refer to "New Class A development and redevelopment properties: current projects" of this Supplemental Information for details on the RSF in service and under construction, if applicable.

(1)Represents the average delivery date for deliveries that occurred during the current quarter, weighted by annual rental revenue.
(2)We expect the development and redevelopment RSF placed in service during the three months ended June 30, 2022 to generate initial annual net operating income of approximately $21 million for the twelve months following delivery.
(3)Relates to total operating RSF placed in service as of the most recent delivery.
New Class A Development and Redevelopment Properties: Current Projects
June 30, 2022

325 Binney Street One Rogers Street 99 Coolidge Avenue 500 North Beacon Street and
4 Kingsbury Avenue
The Arsenal on the Charles
Greater Boston/
Cambridge/Inner Suburbs
Greater Boston/
Cambridge/Inner Suburbs
Greater Boston/
Cambridge/Inner Suburbs
Greater Boston/
Cambridge/Inner Suburbs
Greater Boston/
Cambridge/Inner Suburbs
462,100 RSF 403,892 RSF 320,809 RSF 248,018 RSF 100,108 RSF
100% Leased 100% Leased 36% Leased/Negotiating 85% Leased/Negotiating 95% Leased/Negotiating

201 Brookline Avenue 15 Necco Street 40, 50, and 60 Sylvan Road 840 Winter Street 651 Gateway Boulevard
Greater Boston/Fenway Greater Boston/
Seaport Innovation District
Greater Boston/Route 128 Greater Boston/Route 128 San Francisco Bay Area/
South San Francisco
510,116 RSF 345,995 RSF 202,428 RSF 139,984 RSF 300,010 RSF
96% Leased/Negotiating 97% Leased/Negotiating 61% Leased/Negotiating 100% Leased 7% Leased/Negotiating

New Class A Development and Redevelopment Properties: Current Projects (continued)
June 30, 2022
751 Gateway Boulevard 30-02 48th Avenue 10055 Barnes Canyon Road 1150 Eastlake Avenue East 9810 Darnestown Road
San Francisco Bay Area/
South San Francisco
New York City/New York City San Diego/Sorrento Mesa Seattle/Lake Union Maryland/Rockville
230,592 RSF 65,558 RSF 84,981 RSF 311,631 RSF 192,000 RSF
100% Leased 72% Leased/Negotiating 100% Leased 89% Leased/Negotiating 100% Leased

9808 Medical Center Drive 9601 and 9603 Medical Center Drive
2400 Ellis Road, 40 and 41 Moore Drive, and 14 TW Alexander Drive(1)
4 Davis Drive 6040 George Watts Hill Drive,
Phase II
Maryland/Rockville Maryland/Rockville Research Triangle/Research Triangle Research Triangle/Research Triangle Research Triangle/Research Triangle
90,000 RSF 78,533 RSF 376,871 RSF 180,000 RSF 88,038 RSF
29% Leased/Negotiating 100% Leased 86% Leased/Negotiating -% Leased/Negotiating 100% Leased

(1)Image represents 14 TW Alexander Drive in our Alexandria Center® for Life Science - Durham mega campus.

New Class A Development and Redevelopment Properties: Current Projects (continued)
June 30, 2022
Market
Property/Submarket
Square Footage Percentage
Occupancy(1)
Dev/Redev In Service CIP Total Leased Leased/Negotiating Initial Stabilized
Under construction
Greater Boston
325 Binney Street/Cambridge/Inner Suburbs Dev - 462,100 462,100 100 % 100 % 2023 2024
One Rogers Street/Cambridge/Inner Suburbs Redev 4,367 403,892 408,259 100 100 2023 2023
99 Coolidge Avenue/Cambridge/Inner Suburbs Dev - 320,809 320,809 36 36 2024 2025
500 North Beacon Street and 4 Kingsbury Avenue/Cambridge/Inner Suburbs Dev - 248,018 248,018 85 85 2024 2025
The Arsenal on the Charles/Cambridge/Inner Suburbs Redev 772,557 100,108 872,665 95 95 3Q21 2022
201 Brookline Avenue/Fenway Dev - 510,116 510,116 96 96 2022 2023
15 Necco Street/Seaport Innovation District Dev - 345,995 345,995 97 97 2024 2024
40, 50, and 60 Sylvan Road/Route 128 Redev 312,845 202,428 515,273 61 61 2023 2024
840 Winter Street/Route 128 Redev 28,230 139,984 168,214 100 100 2024 2024
Other Redev - 453,869 453,869 - - 2023 2025
San Francisco Bay Area
651 Gateway Boulevard/South San Francisco Redev - 300,010 300,010 - 7
(2)
2023 2025
751 Gateway Boulevard/South San Francisco Dev - 230,592 230,592 100 100 2023 2023
New York City
30-02 48th Avenue/New York City Redev 113,542 65,558 179,100 67 72 4Q20 2022
San Diego
10055 Barnes Canyon Road/Sorrento Mesa Dev 110,454 84,981 195,435 100 100 2Q22 2022
10102 Hoyt Park Drive/Sorrento Mesa Dev - 144,113 144,113 100 100 2023 2023
Seattle
1150 Eastlake Avenue East/Lake Union Dev - 311,631 311,631 73 89 2023 2024
Alexandria Center® for Advanced Technologies - Monte Villa Parkway/Bothell
Redev 246,647 213,976 460,623 70 70 2022 2023
Maryland
9810 Darnestown Road/Rockville Dev - 192,000 192,000 100 100 2024 2024
9808 Medical Center Drive/Rockville Dev - 90,000 90,000 29 29 2023 2024
9601 and 9603 Medical Center Drive/Rockville Redev 17,378 78,533 95,911 100 100 4Q21 2023
20400 Century Boulevard/Gaithersburg Redev 36,227 44,323 80,550 77 100 1Q22 2023
Research Triangle
2400 Ellis Road, 40 and 41 Moore Drive, and 14 TW Alexander Drive/
Research Triangle
Redev 326,445 376,871 703,316 86 86 2Q21 2024
4 Davis Drive/Research Triangle Dev - 180,000 180,000 - -
(2)
2023 2024
6040 George Watts Hill Drive, Phase II/Research Triangle Dev - 88,038 88,038 100 100 2024 2024
5 and 9 Laboratory Drive/Research Triangle Redev/Dev 278,720 61,680 340,400 96 96 3Q21 2022
Texas
8800 Technology Forest Place/Greater Houston Redev - 201,499 201,499 23 23 2023 2024
2,247,412 5,851,124 8,098,536 74 % 75 %
(1)Initial occupancy dates are subject to leasing and/or market conditions. Multi-tenant projects may have occupancy by tenants over a period of time. Stabilized occupancy may vary depending on single tenancy versus multi-tenancy.
(2)This development project is focused on demand from our existing tenants in our adjacent properties/campuses. This project will also address demand from other non-ARE properties/campuses.
New Class A Development and Redevelopment Properties: Current Projects (continued)
June 30, 2022

Market
Property/Submarket
Square Footage Percentage
Dev/Redev In Service CIP Total Leased Leased/Negotiating
Pre-leased/negotiating near-term projects expected to commence construction in the next six quarters
San Francisco Bay Area
230 Harriet Tubman Way/South San Francisco Dev - 285,346 285,346 100 % 100 %
San Diego
11255 and 11355 North Torrey Pines Road/Torrey Pines Dev - 309,094 309,094 100 100
10931 and 10933 North Torrey Pines Road/Torrey Pines Dev - 299,158 299,158 100 100
Alexandria Point, Phase II/University Town Center Dev - 426,927 426,927 100 100
Alexandria Point, Phase I/University Town Center Dev - 171,102 171,102 100 100
Seattle
701 Dexter Avenue North/Lake Union Dev - 226,586 226,586 - 9
Maryland
9820 Darnestown Road/Rockville Dev - 250,000 250,000 - 100
- 1,968,213 1,968,213 76 89
2,247,412 7,819,337 10,066,749 74 % 78 %
New Class A Development and Redevelopment Properties: Current Projects (continued)
June 30, 2022
(Dollars in thousands)
Our Ownership Interest Unlevered Yields
Market
Property/Submarket
In Service CIP Cost to Complete Total at
Completion
Initial Stabilized Initial Stabilized (Cash Basis)
Under construction
Greater Boston
325 Binney Street/Cambridge/Inner Suburbs 100 % $ - $ 334,164 $ 446,836 $ 781,000 8.6 % 7.2 %
One Rogers Street/Cambridge/Inner Suburbs 100 % 10,765 916,883 278,352 1,206,000 5.2 % 4.2 %
99 Coolidge Avenue/Cambridge/Inner Suburbs 75.0 % - 103,179 TBD
500 North Beacon Street and 4 Kingsbury Avenue/Cambridge/Inner Suburbs 100 % - 85,054 341,946 427,000 6.2 % 5.5 %
The Arsenal on the Charles/Cambridge/Inner Suburbs 100 % 668,330 112,141 50,529 831,000 6.3 % 5.5 %
201 Brookline Avenue/Fenway 98.6 % - 600,014 133,986 734,000 7.2 % 6.2 %
15 Necco Street/Seaport Innovation District 90.0 % - 268,155 298,845 567,000 6.7 % 5.5 %
40, 50, and 60 Sylvan Road/Route 128 100 % 173,674 110,661 TBD
840 Winter Street/Route 128 100 % 13,227 86,450 108,323 208,000 7.5 % 6.5 %
Other 100 % - 120,171 TBD
San Francisco Bay Area
651 Gateway Boulevard/South San Francisco 50.0 % - 129,655 TBD
751 Gateway Boulevard/South San Francisco 51.0 % - 134,513 155,487 290,000 6.5 % 6.3 %
New York City
30-02 48th Avenue/New York City 100 % 115,134 83,635 25,231 224,000 5.8 % 5.8 %
San Diego
10055 Barnes Canyon Road/Sorrento Mesa 50.0 % 67,997 44,054 68,949 181,000 7.2 % 6.6 %
10102 Hoyt Park Drive/Sorrento Mesa 100 % - 65,628 48,372 114,000 7.4 % 6.5 %
Seattle
1150 Eastlake Avenue East/Lake Union 100 % - 154,126 250,874 405,000 6.4 % 6.2 %
Alexandria Center® for Advanced Technologies - Monte Villa Parkway/Bothell
100 % 56,563 76,841 TBD
Maryland
9810 Darnestown Road/Rockville 100 % - 49,148 83,852 133,000 6.9 % 6.2 %
9808 Medical Center Drive/Rockville 100 % - 30,123 TBD
9601 and 9603 Medical Center Drive/Rockville 100 % 6,288 28,911 18,801 54,000 8.4 % 7.1 %
20400 Century Boulevard/Gaithersburg 100 % 15,296 9,747 9,957 35,000 8.5 % 8.6 %
Research Triangle
2400 Ellis Road, 40 and 41 Moore Drive, and 14 TW Alexander Drive/Research Triangle 100 % 93,455 101,799 141,746 337,000 7.5 % 6.7 %
4 Davis Drive/Research Triangle 100 % - 21,362 TBD
5 and 9 Laboratory Drive/Research Triangle 100 % 162,721 37,986 15,293 216,000 7.2 % 7.1 %
6040 George Watts Hill Drive, Phase II/Research Triangle 100 % - 4,256 59,744 64,000 8.0 % 7.0 %
Texas
8800 Technology Forest Place/Greater Houston 100 % - 38,145 TBD
$ 1,383,450 $ 3,746,801 $ 4,210,000
(1)
$ 9,340,000
(1)
(1)Amounts rounded to the nearest $10 million.
New Class A Development and Redevelopment Properties: Summary of Pipeline
June 30, 2022
(Dollars in thousands)

Market
Property/Submarket
Our Ownership Interest Book Value Square Footage
Development and Redevelopment
Under Construction Near
Term
Intermediate
Term
Future
Total(1)
Greater Boston
Mega Campus: Alexandria Center® at One Kendall Square/Cambridge/
Inner Suburbs
100 % $ 334,164 462,100 - - - 462,100
325 Binney Street
Mega Campus: Alexandria Center® at Kendall Square/Cambridge/
Inner Suburbs
100 % 916,883 403,892 - - - 403,892
One Rogers Street
Mega Campus: The Arsenal on the Charles/Cambridge/Inner Suburbs 100 % 207,990 348,126 - - 34,157 382,283
311 Arsenal Street, 400 and 500 North Beacon Street, 100 Talcott Avenue, and 4 Kingsbury Avenue
99 Coolidge Avenue/Cambridge/Inner Suburbs 75.0 % 103,179 320,809 - - - 320,809
Mega Campus: Alexandria Center® for Life Science - Fenway/Fenway
(2)
868,320 510,116 507,997 - - 1,018,113
201 Brookline Avenue and 421 Park Drive
15 Necco Street/Seaport Innovation District 90.0 % 268,155 345,995 - - - 345,995
Reservoir Woods/Route 128 100 % 159,850 202,428 312,845 - 440,000 955,273
40, 50, and 60 Sylvan Road
840 Winter Street/Route 128 100 % 86,450 139,984 28,230 - - 168,214
275 Grove Street/Route 128 100 % - - 160,251 - - 160,251
10 Necco Street/Seaport Innovation District 100 % 96,555 - - 175,000 - 175,000
215 Presidential Way/Route 128 100 % 6,808 - - 112,000 - 112,000
Mega Campus: 480 Arsenal Way and 500 and 550 Arsenal Street/Cambridge/Inner Suburbs 100 % 56,988 - - - 775,000 775,000
550 Arsenal Street
Mega Campus: Alexandria Technology Square®/Cambridge/Inner Suburbs
100 % 7,881 - - - 100,000 100,000
Mega Campus: 380 and 420 E Street/Seaport Innovation District 100 % 123,514 - - - 1,000,000 1,000,000
99 A Street/Seaport Innovation District 100 % 48,882 - - - 235,000 235,000
Mega Campus: One Upland Road, 100 Tech Drive, and One Investors Way/Route 128 100 % 24,264 - - - 1,100,000 1,100,000
Other value-creation projects 100 % 174,664 453,869 190,992 - 466,504 1,111,365
$ 3,484,547 3,187,319 1,200,315 287,000 4,150,661 8,825,295

Refer to "Mega campus" in the "Definitions and reconciliations" of this Supplemental Information for additional details.

(1)Represents total square footage upon completion of development or redevelopment of a new Class A property. Square footage presented includes RSF of buildings currently in operation at properties that also have inherent future development or redevelopment opportunities. Upon expiration of existing in-place leases, we have the intent to demolish or redevelop the existing property and commence future construction. Refer to "Definitions and reconciliations" of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.
(2)We have a 98.6% ownership interest in 201 Brookline Avenue aggregating 510,116 SF, which is currently under construction. We have a 100% ownership interest in the near-term development project at 421 Park Drive aggregating 507,997 SF.
New Class A Development and Redevelopment Properties: Summary of Pipeline (continued)
June 30, 2022
(Dollars in thousands)

Market
Property/Submarket
Our Ownership Interest Book Value Square Footage
Development and Redevelopment
Under Construction Near
Term
Intermediate
Term
Future
Total(1)
San Francisco Bay Area
Mega Campus: Alexandria Technology Center® - Gateway/
South San Francisco
(2)
$ 286,827 530,602 - - 291,000 821,602
651 and 751 Gateway Boulevard
Mega Campus: Alexandria Center® for Science and Technology - Mission Bay/Mission Bay
100 % 74,098 - 191,000 - - 191,000
1450 Owens Street
Alexandria Center® for Life Science - Millbrae/South San Francisco
48.5 % 167,091 - 633,747 - - 633,747
230 Harriet Tubman Way, 201 and 231 Adrian Road, and 6 and 30 Rollins Road
3825 and 3875 Fabian Way/Greater Stanford 100 % - - 250,000 - 228,000 478,000
Mega Campus: Alexandria Center® for Life Science - San Carlos/Greater Stanford
100 % 369,162 - 105,000 700,000 692,830 1,497,830
960 Industrial Road, 987 and 1075 Commercial Street, and 888 Bransten Road
901 California Avenue/Greater Stanford 100 % 6,337 - 56,924 - - 56,924
Mega Campus: 88 Bluxome Street/SoMa 100 % 331,907 - 1,070,925 - - 1,070,925
Mega Campus: 1122, 1150, and 1178 El Camino Real/South San Francisco 100 % 335,885 - - - 1,930,000 1,930,000
Mega Campus: 211(3), 213(3), 249, 259, 269, and 279 East Grand Avenue/
South San Francisco
100 % 6,624 - - - 90,000 90,000
211 East Grand Avenue
Other value-creation projects 100 % - - - - 25,000 25,000
1,577,931 530,602 2,307,596 700,000 3,256,830 6,795,028
New York City
Alexandria Center® for Life Science - Long Island City/New York City
100 % 115,368 65,558 135,938 - - 201,496
30-02 48th Avenue and 47-50 30th Street
Mega Campus: Alexandria Center® for Life Science - New York City/
New York City
100 % 98,380 - - 550,000
(4)
- 550,000
219 East 42nd Street/New York City 100 % - - - - 579,947 579,947
$ 213,748 65,558 135,938 550,000 579,947 1,331,443

Refer to "Mega campus" in the "Definitions and reconciliations" of this Supplemental Information for additional details.

(1)Represents total square footage upon completion of development or redevelopment of a new Class A property. Square footage presented includes RSF of buildings currently in operation at properties that also have inherent future development or redevelopment opportunities. Upon expiration of existing in-place leases, we have the intent to demolish or redevelop the existing property and commence future construction. Refer to "Definitions and reconciliations" of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.
(2)We own a 50.0% ownership interest in 651 Gateway Boulevard aggregating 300,010 RSF and a 51.0% ownership interest in 751 Gateway Boulevard aggregating 230,592 RSF.
(3)We own a partial interest in this property through a real estate joint venture. Refer to "Joint venture financial information" of this Supplemental Information for additional details.
(4)Pursuant to an option agreement, we are currently negotiating a long-term ground lease with the City of New York for the future site of a new building approximating 550,000 SF.
New Class A Development and Redevelopment Properties: Summary of Pipeline (continued)
June 30, 2022
(Dollars in thousands)

Market
Property/Submarket
Our Ownership Interest Book Value Square Footage
Development and Redevelopment
Under Construction Near
Term
Intermediate
Term
Future
Total(1)
San Diego
Mega Campus: SD Tech by Alexandria/Sorrento Mesa 50.0 % $ 143,560 84,981 190,074 160,000 333,845 768,900
9805 Scranton Road and 10055 and 10075 Barnes Canyon Road
Scripps Science Park by Alexandria/Sorrento Mesa 100 % 121,206 144,113 105,000 70,041 164,000 483,154
10102 Hoyt Park Drive, 10048 and 12019 Meanley Drive, and 10277 Scripps Ranch Boulevard
Mega Campus: One Alexandria Square/Torrey Pines 100 % 224,288 - 608,252 - 125,280 733,532
10931, 10933, 11255, and 11355 North Torrey Pines Road and 10975 and 10995 Torreyana Road
Mega Campus: Alexandria Point/University Town Center 55.0 % 130,202 - 598,029 - 324,445 922,474
10260 Campus Point Drive and 4110, 4150, and 4161 Campus Point Court
Mega Campus: Sequence District by Alexandria/Sorrento Mesa 100 % 41,334 - 200,000 509,000 1,089,915 1,798,915
6260, 6290, 6310, 6340, 6350, and 6450 Sequence Drive
Mega Campus: University District/University Town Center 100 % 193,622 - - 1,137,000 - 1,137,000
9363, 9373, 9393 Towne Centre Drive, 4555 Executive Drive, 8410-8750 Genesee Avenue, and 4282 Esplanade Court
9444 Waples Street/Sorrento Mesa 50.0 % 21,058 - - 149,000 - 149,000
Mega Campus: 5200 Illumina Way/University Town Center 51.0 % 14,487 - - - 451,832 451,832
4025, 4031, 4045, and 4075 Sorrento Valley Boulevard/Sorrento Valley 100 % 20,281 - - - 247,000 247,000
Other value-creation projects 100 % 71,919 - - - 539,235 539,235
981,957 229,094 1,701,355 2,025,041 3,275,552 7,231,042
Seattle
Mega Campus: The Eastlake Life Science Campus by Alexandria/
Lake Union
100 % 154,126 311,631 - - - 311,631
1150 Eastlake Avenue East
Alexandria Center® for Advanced Technologies - Monte Villa Parkway/Bothell
100 % 76,841 213,976 50,552 - - 264,528
3301, 3555, and 3755 Monte Villa Parkway
Mega Campus: Alexandria Center® for Life Science - South Lake Union/
Lake Union
(2)
342,946 - 1,095,586 - 188,400 1,283,986
601 and 701 Dexter Avenue North and 800 Mercer Street
830 and 1010 4th Avenue South/SoDo 100 % $ 52,789 - - - 597,313 597,313

Refer to "Mega campus" in the "Definitions and reconciliations" of this Supplemental Information for additional details.

(1)Represents total square footage upon completion of development or redevelopment of a new Class A property. Square footage presented includes RSF of buildings currently in operation at properties that also have inherent future development or redevelopment opportunities. Upon expiration of existing in-place leases, we have the intent to demolish or redevelop the existing property and commence future construction. Refer to "Definitions and reconciliations" of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.
(2)We have a 100% ownership interest in 601 and 701 Dexter Avenue North aggregating 414,986 SF and a 60% ownership interest in the near-term development project at 800 Mercer Street aggregating 869,000 SF.
New Class A Development and Redevelopment Properties: Summary of Pipeline (continued)
June 30, 2022
(Dollars in thousands)

Market
Property/Submarket
Our Ownership Interest Book Value Square Footage
Development and Redevelopment
Under Construction Near
Term
Intermediate
Term
Future
Total(1)
Seattle (continued)
Mega Campus: Alexandria Center® for Advanced Technologies - Canyon Park/Bothell
100 % $ 13,392 - - - 230,000 230,000
21660 20th Avenue Southeast
Other value-creation projects 100 % 79,258 - - - 691,000 691,000
719,352 525,607 1,146,138 - 1,706,713 3,378,458
Maryland
Mega Campus: Alexandria Center® for Life Science - Shady Grove/Rockville
100 % 143,407 360,533 250,000 258,000 38,000 906,533
9601, 9603, and 9808 Medical Center Drive and 9810, 9820, and 9830 Darnestown Road
20400 Century Boulevard/Gaithersburg 100 % 9,747 44,323 - - - 44,323
153,154 404,856 250,000 258,000 38,000 950,856
Research Triangle
Mega Campus: Alexandria Center® for Life Science - Durham/
Research Triangle
100 % 248,421 376,871 - - 2,060,000 2,436,871
40 and 41 Moore Drive and 14 TW Alexander Drive
Mega Campus: Alexandria Center® for Advanced Technologies/
Research Triangle
100 % 56,401 180,000 - - 990,000 1,170,000
4 and 12 Davis Drive
6040 George Watts Hill Drive, Phase II/Research Triangle 100 % 4,256 88,038 - - - 88,038
Alexandria Center® for AgTech/Research Triangle
100 % 37,986 61,680 - - - 61,680
9 Laboratory Drive
Mega Campus: Alexandria Center® for NextGen Medicines/
Research Triangle
100 % 98,089 - 100,000 100,000 855,000 1,055,000
3029 East Cornwallis Road
120 TW Alexander Drive, 2752 East NC Highway 54, and 10 South Triangle Drive/Research Triangle 100 % 50,121 - - - 750,000 750,000
Other value-creation projects 100 % 4,185 - - - 76,262 76,262
499,459 706,589 100,000 100,000 4,731,262 5,637,851
Texas
8800 Technology Forest Place/Greater Houston 100 % 42,981 201,499 - - 116,287 317,786
Other value-creation projects 100 % 136,837 - 143,105 - 2,090,000 2,233,105
179,818 201,499 143,105 - 2,206,287 2,550,891
Other value-creation projects 100 % 33,438 - - - 474,000 474,000
Total pipeline as of June 30, 2022
$ 7,843,404
(2)
5,851,124 6,984,447 3,920,041 20,419,252 37,174,864
(1)
Refer to "Mega campus" in the "Definitions and reconciliations" of this Supplemental Information for additional details.

(1)Total square footage includes 4,170,757 RSF of buildings currently in operation that will be redeveloped or replaced with new development RSF upon commencement of future construction. Refer to "Definitions and reconciliations" of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.
(2)Total book value includes $3.7 billion of projects currently under construction that are 75% leased/negotiating. We also expect to commence construction on pre-leased/negotiating near-term projects aggregating $441.8 million in the next six quarters that are 89% leased/negotiating.
Construction Spending
June 30, 2022
(In thousands)


Six Months Ended
Construction Spending June 30, 2022
Additions to real estate -consolidated projects
$ 1,377,589
Investments in unconsolidated real estate joint ventures 336
Contributions from noncontrolling interests (99,215)
Construction spending (cash basis) 1,278,710
Change in accrued construction 115,575
Construction spending 1,394,285
Projected construction spending for the six months ending December 31, 2022 1,605,715
Guidance midpoint $ 3,000,000
(1)
Year Ending
Projected Construction Spending December 31, 2022
Development, redevelopment, and pre-construction projects $ 3,106,000
Contributions from noncontrolling interests (consolidated real estate joint ventures)
(286,000)
Revenue-enhancing and repositioning capital expenditures
98,000
Non-revenue-enhancing capital expenditures
82,000
Guidance midpoint $ 3,000,000
(1)

(1)During the three months ended June 30, 2022, we reduced our projected construction spending for the remainder of 2022 by $285 million. Refer to "Guidance" in the Earnings Press Release of our Supplemental Information for additional details.
Joint Venture Financial Information
June 30, 2022
Consolidated Real Estate Joint Ventures
Property Market Submarket
Noncontrolling
Interest Share(1)
Operating RSF
at 100%
50 and 60 Binney Street Greater Boston Cambridge/Inner Suburbs 66.0% 532,395
75/125 Binney Street Greater Boston Cambridge/Inner Suburbs 60.0% 388,270
100 Binney Street Greater Boston Cambridge/Inner Suburbs 70.0% 432,931
225 Binney Street Greater Boston Cambridge/Inner Suburbs 70.0% 305,212
300 Third Street Greater Boston Cambridge/Inner Suburbs 70.0% 131,963
99 Coolidge Avenue Greater Boston Cambridge/Inner Suburbs 25.0% -
(2)
Alexandria Center® for Science and Technology - Mission Bay(3)
San Francisco Bay Area Mission Bay 75.0% 1,005,989
601, 611, 651, 681, 685, and 701 Gateway Boulevard San Francisco Bay Area South San Francisco 50.0% 789,567
751 Gateway Boulevard San Francisco Bay Area South San Francisco 49.0% -
(2)
213 East Grand Avenue San Francisco Bay Area South San Francisco 70.0% 300,930
500 Forbes Boulevard San Francisco Bay Area South San Francisco 90.0% 155,685
Alexandria Center® for Life Science - Millbrae
San Francisco Bay Area South San Francisco 51.5% -
Alexandria Point(4)
San Diego University Town Center 45.0% 1,337,916
5200 Illumina Way San Diego University Town Center 49.0% 792,687
9625 Towne Centre Drive San Diego University Town Center 49.9% 163,648
SD Tech by Alexandria(5)
San Diego Sorrento Mesa 50.0% 793,957
Pacific Technology Park San Diego Sorrento Mesa 50.0% 572,887
1201 and 1208 Eastlake Avenue East and 199 East Blaine Street Seattle Lake Union 70.0% 321,218
400 Dexter Avenue North Seattle Lake Union 70.0% 290,111
800 Mercer Street Seattle Lake Union 40.0% -
Unconsolidated Real Estate Joint Ventures
Property Market Submarket
Our Ownership Share(6)
Operating RSF
at 100%
1655 and 1725 Third Street San Francisco Bay Area Mission Bay 10.0% 586,208
1401/1413 Research Boulevard Maryland Rockville 65.0%
(7)
(8)
1450 Research Boulevard Maryland Rockville 73.2%
(9)
42,679
101 West Dickman Street Maryland Beltsville 57.9%
(9)
135,423

(1)In addition to the consolidated real estate joint ventures listed, various partners hold insignificant noncontrolling interests in three other real estate joint ventures in North America.
(2)Represents a property currently under construction. Refer to "New Class A development and redevelopment properties: current projects" for additional details.
(3)Includes 409 and 499 Illinois Street, 1500 and 1700 Owens Street, and 455 Mission Bay Boulevard South.
(4)Includes 10210, 10260, 10290, and 10300 Campus Point Drive and 4110, 4150, 4161, 4224, and 4242 Campus Point Court in our University Town Center submarket.
(5)Includes 9605, 9645, 9675, 9685, 9725, 9735, 9808, 9855, and 9868 Scranton Road and 10055 and 10065 Barnes Canyon Road in our Sorrento Mesa submarket.
(6)In addition to the unconsolidated real estate joint ventures listed, we hold an interest in one other insignificant unconsolidated real estate joint venture in North America.
(7)Represents our ownership interest; our voting interest is limited to 50%.
(8)Represents a joint venture with a distinguished retail real estate developer for an approximately 90,000 RSF retail shopping center.
(9)Represents a joint venture with a local real estate operator in which our partner manages the day-to-day activities that significantly affect the economic performance of the joint venture.
Joint Venture Financial Information (continued)
June 30, 2022
(In thousands)


As of June 30, 2022
Noncontrolling Interest
Share of Consolidated
Real Estate JVs
Our Share of
Unconsolidated Real
Estate JVs
Investments in real estate $ 3,036,883 $ 110,461
Cash, cash equivalents, and restricted cash 110,417 4,466
Other assets 351,455 10,400
Secured notes payable (refer to page 53)
(6,077) (83,998)
Other liabilities (169,877) (3,742)
Redeemable noncontrolling interests (9,612) -
$ 3,313,189 $ 37,587

Noncontrolling Interest Share of Consolidated Real Estate JVs Our Share of Unconsolidated Real Estate JVs
June 30, 2022 June 30, 2022
Three Months Ended Six Months Ended Three Months Ended Six Months Ended
Total revenues $ 89,263 $ 167,940 $ 2,728 $ 5,566
Rental operations (25,331) (48,028) (638) (1,370)
63,932 119,912 2,090 4,196
General and administrative (547) (870) (25) (96)
Interest - - (918) (1,778)
Depreciation and amortization of real estate assets (26,418) (50,099) (934) (1,889)
Fixed returns allocated to redeemable noncontrolling interests(1)
201 402 - -
$ 37,168 $ 69,345 $ 213 $ 433
Straight-line rent and below-market lease revenue $ 4,309 $ 8,633 $ 287 $ 540
Funds from operations(2)
$ 63,586 $ 119,444 $ 1,147 $ 2,322

(1)Represents an allocation of joint venture earnings to redeemable noncontrolling interests primarily in one property in our South San Francisco submarket. These redeemable noncontrolling interests earn a fixed return on their investment rather than participate in the operating results of the property.
(2)Refer to "Funds from operations and funds from operations per share" in our Earnings Press Release and "Funds from operations and funds from operations, as adjusted, attributable to Alexandria's common stockholders" in the "Definitions and reconciliations" of this Supplemental Information for the definition and reconciliation from the most directly comparable financial measure presented in accordance with GAAP.

Investments
June 30, 2022
(Dollars in thousands)

We hold investments in publicly traded companies and privately held entities primarily involved in the life science, agtech, and technology industries. The tables below summarize components of our non-real estate investments and investment income. For additional details, refer to "Investments" in the "Definitions and reconciliations" of this Supplemental Information.

June 30, 2022
Three Months Ended Six Months Ended Year Ended December 31, 2021
Realized gains $ 28,647 $ 51,761 $ 215,845
(1)
Unrealized (losses) gains (68,128) (331,561) 43,632
Investment (loss) income $ (39,481) $ (279,800) $ 259,477

June 30, 2022
Investments Cost Unrealized
Gains
Carrying Amount
Publicly traded companies $ 220,033 $ 24,292
(2)
$ 244,325
Entities that report NAV 433,133 355,062 788,195
Entities that do not report NAV:
Entities with observable price changes
68,744 80,457 149,201
Entities without observable price changes
395,271 - 395,271
Investments accounted for under the equity method of accounting N/A N/A 80,469
June 30, 2022 $ 1,117,181
(3)
$ 459,811
(4)
$ 1,657,461
December 31, 2021 $ 1,007,303 $ 797,673 $ 1,876,564

(1)Includes six separate significant realized gains aggregating $110.1 million related to the following transactions: (i) the sales of investments in three publicly traded biotechnology companies, (ii) a distribution received from a limited partnership investment, and (iii) the acquisition of two of our privately held non-real estate investments in a biopharmaceutical company and a biotechnology company.
(2)Comprises gross unrealized gains and losses of $122.5 million and $98.2 million, respectively.
(3)Represents 3.0% of gross assets as of June 30, 2022.
(4)Comprises gross unrealized gains and losses of $565.5 million and $105.7 million, respectively.

Public/Private
Mix (Cost)
Tenant/Non-Tenant
Mix (Cost)
Key Credit Metrics
June 30, 2022

Liquidity Minimal Outstanding Borrowings and Significant Availability on Unsecured Senior Line of Credit
(in millions)
$5.5B
(in millions)
Availability under our unsecured senior line of credit, net of amounts outstanding under our commercial paper program $ 2,850
Outstanding forward equity sales agreements(1)
1,697
Cash, cash equivalents, and restricted cash 518
Remaining construction loan commitments 169
Investments in publicly traded companies 244
Liquidity as of June 30, 2022
$ 5,478
Net Debt and Preferred Stock to Adjusted EBITDA(2)
Fixed-Charge Coverage Ratio(2)
(1)Represents expected net proceeds from the future settlement of 9.0 million shares of forward equity sales agreements.
(2)Quarter annualized. Refer to "Fixed-charge coverage ratio" and "Net debt and preferred stock to Adjusted EBITDA" in the "Definitions and reconciliations"of this Supplemental Information for additional details.
Summary of Debt
June 30, 2022
(In millions)


Weighted-Average Remaining Term of 13.6 Years
(1)Refer to footnote 3 on the next page under "Fixed-rate and variable-rate debt" for additional details.
Summary of Debt (continued)
June 30, 2022
(Dollars in thousands)

Fixed-rate and variable-rate debt Fixed-Rate
Debt
Variable-Rate Debt Total Percentage Weighted-Average
Interest Rate(1)
Remaining Term
(in years)
Secured notes payable $ 678 $ 24,308 $ 24,986 0.2 % 3.78 % 4.6
Unsecured senior notes payable 10,096,462 - 10,096,462 98.3 3.51 13.8
Unsecured senior line of credit(2)
- - - - N/A 3.5
Commercial paper program - 149,958 149,958 1.5 2.02
(3)
Total/weighted average $ 10,097,140 $ 174,266 $ 10,271,406 100.0 % 3.49 % 13.6
(3)
Percentage of total debt 98.3 % 1.7 % 100.0 %
(1)Represents the weighted-average interest rate as of the end of the applicable period, including expense/income related to the amortization of loan fees, amortization of debt premiums (discounts), and other bank fees.
(2)During the year ended December 31, 2021, we achieved certain sustainability measures, as described in our unsecured senior line of credit agreement, which reduced the borrowing rate by one basis point for a one-year period to LIBOR+0.815% from LIBOR+0.825%.
(3)The commercial paper program provides us with the ability to issue up to $1.5 billion of commercial paper notes that bear interest at short-term fixed rates and can generally be issued with a maturity of 30 days or less and with a maximum maturity of 397 days from the date of issuance. Borrowings under the program are used to fund short-term capital needs and are backed by our unsecured senior line of credit. There was $150.0 million of commercial paper notes outstanding as of June 30, 2022. In the event we are unable to issue commercial paper notes or refinance outstanding borrowings under terms equal to or more favorable than those under our unsecured senior line of credit, we expect to borrow under the unsecured senior line of credit at L+0.815%. As such, we calculate the weighted-average remaining term of our commercial paper notes by using the maturity date of our unsecured senior line of credit. Using the maturity date of our outstanding commercial paper, the consolidated weighted-average maturity of our debt is 13.5 years. The commercial paper notes sold during the three months ended June 30, 2022 were issued at a weighted-average yield to maturity of 1.35% and had a weighted-average maturity term of 11 days.

Debt covenants Unsecured Senior Notes Payable Unsecured Senior Line of Credit
Debt Covenant Ratios(1)
Requirement June 30, 2022 Requirement June 30, 2022
Total Debt to Total Assets ≤ 60% 29% ≤ 60.0% 28.5%
Secured Debt to Total Assets ≤ 40% 0.1% ≤ 45.0% 0.1%
Consolidated EBITDA to Interest Expense ≥ 1.5x 15.7x ≥ 1.50x 4.55x
Unencumbered Total Asset Value to Unsecured Debt ≥ 150% 333% N/A N/A
Unsecured Interest Coverage Ratio N/A N/A ≥ 1.75x 11.91x
(1)All covenant ratio titles utilize terms as defined in the respective debt and credit agreements. The calculation of consolidated EBITDA is based on the definitions contained in our loan agreements and is not directly comparable to the computation of EBITDA as described in Exchange Act Release No. 47226.

Unconsolidated real estate joint ventures' debt At 100%
Unconsolidated Joint Venture Our Share Maturity Date Stated Rate
Interest Rate(1)
Aggregate Commitment
Debt Balance(2)
1401/1413 Research Boulevard 65.0% 12/23/24 2.70% 3.32% $ 28,500 $ 28,064
1655 and 1725 Third Street
10.0% 3/10/25 4.50% 4.57% 600,000 598,868
101 West Dickman Street 57.9% 11/10/26 SOFR+1.95%
(3)
3.51% 26,750 10,129
1450 Research Boulevard 73.2% 12/10/26 SOFR+1.95%
(3)
N/A 13,000 -
$ 668,250 $ 637,061
(1)Includes interest expense and amortization of loan fees.
(2)Represents outstanding principal, net of unamortized deferred financing costs, as of June 30, 2022.
(3)This loan is subject to a fixed SOFR floor rate of 0.75%.
Summary of Debt (continued)
June 30, 2022
(Dollars in thousands)

Debt Stated
Rate
Interest
Rate(1)
Maturity
Date(2)
Principal Payments Remaining for the Periods Ending December 31, Principal Unamortized (Deferred Financing Cost), (Discount)/Premium Total
2022 2023 2024 2025 2026 Thereafter
Secured notes payable
Greater Boston(3)
SOFR+2.70 % 3.71 % 11/19/26 $ - $ - $ - $ - $ 25,975 $ - $ 25,975 $ (1,667) $ 24,308
San Francisco Bay Area 6.50 % 6.50 7/1/36 28 30 32 34 36 518 678 - 678
Secured debt weighted-average interest rate/subtotal
2.80 % 3.78 28 30 32 34 26,011 518 26,653 (1,667) 24,986
Commercial paper program(4)(5)
2.02 %
(4)
2.02
(4)
(4)
(4)
- - - 150,000
(4)
- 150,000 (42) 149,958
Unsecured senior line of credit(5)
L+0.815 % N/A 1/6/26 - - - - - - - - -
Unsecured senior notes payable
3.45 % 3.62 4/30/25 - - - 600,000 - - 600,000 (2,498) 597,502
Unsecured senior notes payable
4.30 % 4.50 1/15/26 - - - - 300,000 - 300,000 (1,748) 298,252
Unsecured senior notes payable - green bond
3.80 % 3.96 4/15/26 - - - - 350,000 - 350,000 (1,873) 348,127
Unsecured senior notes payable
3.95 % 4.13 1/15/27 - - - - - 350,000 350,000 (2,323) 347,677
Unsecured senior notes payable
3.95 % 4.07 1/15/28 - - - - - 425,000 425,000 (2,361) 422,639
Unsecured senior notes payable
4.50 % 4.60 7/30/29 - - - - - 300,000 300,000 (1,579) 298,421
Unsecured senior notes payable
2.75 % 2.87 12/15/29 - - - - - 400,000 400,000 (3,082) 396,918
Unsecured senior notes payable
4.70 % 4.81 7/1/30 - - - - - 450,000 450,000 (2,982) 447,018
Unsecured senior notes payable
4.90 % 5.05 12/15/30 - - - - - 700,000 700,000 (6,679) 693,321
Unsecured senior notes payable
3.375 % 3.48 8/15/31 - - - - - 750,000 750,000 (5,946) 744,054
Unsecured senior notes payable - green bond 2.00 % 2.12 5/18/32 - - - - - 900,000 900,000 (9,257) 890,743
Unsecured senior notes payable
1.875 % 1.97 2/1/33 - - - - - 1,000,000 1,000,000 (9,272) 990,728
Unsecured senior notes payable - green bond 2.95 % 3.07 3/15/34 - - - - - 800,000 800,000 (9,109) 790,891
Unsecured senior notes payable
4.85 % 4.93 4/15/49 - - - - - 300,000 300,000 (3,159) 296,841
Unsecured senior notes payable
4.00 % 3.91 2/1/50 - - - - - 700,000 700,000 10,273 710,273
Unsecured senior notes payable
3.00 % 3.08 5/18/51 - - - - - 850,000 850,000 (12,176) 837,824
Unsecured senior notes payable
3.55 % 3.63 3/15/52 - - - - - 1,000,000 1,000,000 (14,767) 985,233
Unsecured debt weighted average/subtotal
3.49 - - - 600,000 800,000 8,925,000 10,325,000 (78,580) 10,246,420
Weighted-average interest rate/total
3.49 % $ 28 $ 30 $ 32 $ 600,034 $ 826,011 $ 8,925,518 $ 10,351,653 $ (80,247) $ 10,271,406
Balloon payments
$ - $ - $ - $ 600,000 $ 825,975 $ 8,925,068 $ 10,351,043 $ - $ 10,351,043
Principal amortization
28 30 32 34 36 450 610 (80,247) (79,637)
Total debt $ 28 $ 30 $ 32 $ 600,034 $ 826,011 $ 8,925,518 $ 10,351,653 $ (80,247) $ 10,271,406
Fixed-rate debt $ 28 $ 30 $ 32 $ 600,034 $ 650,036 $ 8,925,518 $ 10,175,678 $ (78,538) $ 10,097,140
Variable-rate debt - - - - 175,975 - 175,975 (1,709) 174,266
Total debt
$ 28 $ 30 $ 32 $ 600,034 $ 826,011 $ 8,925,518 $ 10,351,653 $ (80,247) $ 10,271,406
Weighted-average stated rate on maturing debt
N/A N/A N/A 3.45% 3.62% 3.36%
(1)Represents the weighted-average interest rate as of the end of the applicable period, including amortization of loan fees, amortization of debt premiums (discounts), and other bank fees.
(2)Reflects any extension options that we control.
(3)Represents a secured construction loan held by our consolidated real estate joint venture at 99 Coolidge Avenue, of which we own a 75.0% interest. As of June 30, 2022, this joint venture has $169.3 million available under the existing lender commitments. The interest rate shall be reduced from SOFR+2.70% to SOFR+2.10% over time upon the completion of certain leasing, construction, and financial covenant milestones.
(4)Refer to footnote 3 on the prior page under "Fixed-rate and variable-rate debt."
(5)We plan to amend and extend our unsecured senior line of credit in 2H22. We may also consider increasing the size of our commercial paper program up to 50% of the total commitments under our unsecured senior line of credit.
Definitions and Reconciliations
June 30, 2022

This section contains additional details for sections throughout this Supplemental Information and the accompanying Earnings Press Release, as well as explanations and reconciliations of certain non-GAAP financial measures and the reasons why we use these supplemental measures of performance and believe they provide useful information to investors. Additional detail can be found in our most recent annual report on Form 10-K and subsequent quarterly reports on Form 10-Q, as well as other documents filed with or furnished to the SEC from time to time.

Adjusted EBITDA and Adjusted EBITDA margin
The following table reconciles net income (loss), the most directly comparable financial measure calculated and presented in accordance with GAAP, to Adjusted EBITDA and calculates the Adjusted EBITDA margin:
Three Months Ended
(Dollars in thousands)
6/30/22 3/31/22 12/31/21 9/30/21 6/30/21
Net income (loss) $ 309,382 $ (117,392) $ 99,796 $ 124,433 $ 404,520
Interest expense
24,257 29,440 34,862 35,678 35,158
Income taxes
2,089 3,571 4,156 3,672 2,800
Depreciation and amortization 242,078 240,659 239,254 210,842 190,052
Stock compensation expense 14,340 14,028 14,253 9,728 12,242
Loss on early extinguishment of debt
3,317 - - - -
(Gain) loss on sales of real estate (214,219) - (124,226) 435 -
Significant realized gains on non-real estate investments - - - (52,427) (34,773)
Unrealized losses (gains) on non-real estate investments 68,128 263,433 139,716 14,432 (244,031)
Impairment of real estate
- - - 42,620 4,926
Adjusted EBITDA
$ 449,372 $ 433,739 $ 407,811 $ 389,413 $ 370,894
Total revenues $ 643,764 $ 615,065 $ 576,923 $ 547,759 $ 509,619
Adjusted EBITDA margin
70% 71% 71% 71% 73%

We use Adjusted EBITDA as a supplemental performance measure of our operations, for financial and operational decision-making, and as a supplemental means of evaluating period-to-period comparisons on a consistent basis. Adjusted EBITDA is calculated as earnings before interest, taxes, depreciation, and amortization ("EBITDA"), excluding stock compensation expense, gains or losses on early extinguishment of debt, gains or losses on sales of real estate, impairments of real estate, and significant termination fees. Adjusted EBITDA also excludes unrealized gains or losses and significant realized gains or losses and impairments that result from our non-real estate investments. These non-real estate investment amounts are classified in our consolidated statements of operations outside of total revenues.

We believe Adjusted EBITDA provides investors with relevant and useful information as it allows investors to evaluate the operating performance of our business activities without having to account for differences recognized because of investing and financing decisions related to our real estate and non-real estate investments, our capital structure, capital market transactions, and variances resulting from the volatility of market conditions outside of our control. For example, we exclude gains or losses on the early extinguishment of debt to allow investors to measure our performance independent of our indebtedness and capital structure. We believe that adjusting for the effects of impairments and gains or losses on sales of real estate, significant impairments and realized gains or losses on non-real estate investments, and significant termination fees allows investors to evaluate performance from period to period on a consistent basis without having to account for differences recognized because of investing and financing decisions related to our real estate and non-real estate investments or other corporate activities that may not be representative of the operating performance of our properties.

In addition, we believe that excluding charges related to stock compensation and unrealized gains or losses facilitates for investors a comparison of our business activities across periods without the volatility resulting from market forces outside of our control. Adjusted EBITDA has limitations as a measure of our performance. Adjusted EBITDA does not reflect our historical expenditures or future requirements for capital expenditures or contractual commitments. While Adjusted EBITDA is a relevant measure of performance, it does not represent net income (loss) or cash flows from operations calculated and presented in accordance with GAAP, and it should not be considered as an alternative to those indicators in evaluating performance or liquidity.

In order to calculate the Adjusted EBITDA margin, we divide Adjusted EBITDA by total revenues as presented in our consolidated statements of operations. We believe that this supplemental performance measure provides investors with additional useful information regarding the profitability of our operating activities.

Annual rental revenue

Annual rental revenue represents the annualized fixed base rental obligations, calculated in accordance with GAAP, for leases in effect as of the end of the period, related to our operating RSF. Annual rental revenue is presented using 100% of the annual rental revenue from our consolidated properties and our share of annual rental revenue for our unconsolidated real estate joint ventures. Annual rental revenue per RSF is computed by dividing annual rental revenue by the sum of 100% of the RSF of our consolidated properties and our share of the RSF of properties held in unconsolidated real estate joint ventures. As of June 30, 2022, approximately 91% of our leases (on an annual rental revenue basis) were triple net leases, which require tenants to pay substantially all real estate taxes, insurance, utilities, repairs and maintenance, common area expenses, and other operating expenses (including increases thereto) in addition to base rent. Annual rental revenue excludes these operating expenses recovered from our tenants. Amounts recovered from our tenants related to these operating expenses, along with base rent, are classified in income from rentals in our consolidated statements of operations.

Capitalization rates

Capitalization rates are calculated based on net operating income and net operating income (cash basis) annualized for the quarter preceding the date on which the property is sold, or near term prospective net operating income.
Definitions and Reconciliations (continued)
June 30, 2022
Cash interest

Cash interest is equal to interest expense calculated in accordance with GAAP plus capitalized interest, less amortization of loan fees and debt premiums (discounts). Refer to the definition of fixed-charge coverage ratio for a reconciliation of interest expense, the most directly comparable financial measure calculated and presented in accordance with GAAP, to cash interest.

Class A properties and AAA locations

Class A properties are properties clustered in AAA locations that provide innovative tenants with highly dynamic and collaborative environments that enhance their ability to successfully recruit and retain world-class talent and inspire productivity, efficiency, creativity, and success. Class A properties generally command higher annual rental rates than other classes of similar properties.

AAA locations are in close proximity to concentrations of specialized skills, knowledge, institutions, and related businesses. Such locations are generally characterized by high barriers to entry for new landlords, high barriers to exit for tenants, and a limited supply of available space.

Construction costs related to active development and redevelopment projects under contract

Includes (i) costs incurred to date, (ii) remaining costs to complete under a general contractor's guaranteed maximum price construction contract or other fixed contracts, and (iii) our maximum committed tenant improvement allowances under our executed leases. The general contractor's guaranteed maximum price contract or other fixed contracts reduce our exposure to costs of construction materials, labor, and services from third-party contractors and suppliers, unless the overruns result from, among other things, a force majeure event or a change in the scope of work covered by the contract.

Development, redevelopment, and pre-construction

A key component of our business model is our disciplined allocation of capital to the development and redevelopment of new Class A properties, and property enhancements identified during the underwriting of certain acquired properties, located in collaborative life science, agtech, and technology campuses in AAA innovation clusters. These projects are generally focused on providing high-quality, generic, and reusable spaces that meet the real estate requirements of, and are reusable by, a wide range of tenants. Upon completion, each value-creation project is expected to generate a significant increase in rental income, net operating income, and cash flows. Our development and redevelopment projects are generally in locations that are highly desirable to high-quality entities, which we believe results in higher occupancy levels, longer lease terms, higher rental income, higher returns, and greater long-term asset value.

Development projects generally consist of the ground-up development of generic and reusable facilities. Redevelopment projects consist of the permanent change in use of office, warehouse, and shell space into office/laboratory, agtech, or tech office space. We generally will not commence new development projects for aboveground construction of new Class A office/laboratory, agtech, and tech office space without first securing significant pre-leasing for such space, except when there is solid market demand for high-quality Class A properties.

Pre-construction activities include entitlements, permitting, design, site work, and other activities preceding commencement of construction of aboveground building improvements. The advancement of pre-construction efforts is focused on reducing the time required to deliver projects to prospective tenants. These critical activities add significant value for future ground-up development and are required for the vertical construction of buildings. Ultimately, these projects will provide high-quality facilities and are expected to generate significant revenue and cash flows.

Development, redevelopment, and pre-construction spending also includes the following costs: (i) amounts to bring certain acquired properties up to market standard and/or other costs identified during the acquisition process (generally within two years of acquisition) and (ii) permanent conversion of space for highly flexible, move-in-ready office/laboratory space to foster the growth of promising early- and growth-stage life science companies.

Revenue-enhancing and repositioning capital expenditures represent spending to reposition or significantly change the use of a property, including through improvement in the asset quality from Class B to Class A.

Non-revenue-enhancing capital expenditures represent costs required to maintain the current revenues of a stabilized property, including the associated costs for renewed and re-leased space.

Dividend payout ratio (common stock)

Dividend payout ratio (common stock) is the ratio of the absolute dollar amount of dividends on our common stock (shares of common stock outstanding on the respective record dates multiplied by the related dividend per share) to funds from operations attributable to Alexandria's common stockholders - diluted, as adjusted.

Dividend yield

Dividend yield for the quarter represents the annualized quarter dividend divided by the closing common stock price at the end of the quarter.

Space Intentionally Blank

Definitions and Reconciliations (continued)
June 30, 2022
Fixed-charge coverage ratio

Fixed-charge coverage ratio is a non-GAAP financial measure representing the ratio of Adjusted EBITDA to fixed charges. We believe that this ratio is useful to investors as a supplemental measure of our ability to satisfy fixed financing obligations and preferred stock dividends. Cash interest is equal to interest expense calculated in accordance with GAAP plus capitalized interest, less amortization of loan fees and debt premiums (discounts).

The following table reconciles interest expense, the most directly comparable financial measure calculated and presented in accordance with GAAP, to cash interest and computes fixed-charge coverage ratio:
Three Months Ended
(Dollars in thousands) 6/30/22 3/31/22 12/31/21 9/30/21 6/30/21
Adjusted EBITDA $ 449,372 $ 433,739 $ 407,811 $ 389,413 $ 370,894
Interest expense
$ 24,257 $ 29,440 $ 34,862 $ 35,678 $ 35,158
Capitalized interest 68,202 57,763 44,078 43,185 43,492
Amortization of loan fees (3,236) (3,103) (2,911) (2,854) (2,859)
Amortization of debt (discounts) premiums (267) 424 502 498 465
Cash interest and fixed charges $ 88,956 $ 84,524 $ 76,531 $ 76,507 $ 76,256
Fixed-charge coverage ratio:
- quarter annualized 5.1x 5.1x 5.3x 5.1x 4.9x
- trailing 12 months 5.1x 5.1x 5.0x 4.8x 4.6x
Funds from operations and funds from operations, as adjusted, attributable to Alexandria's common stockholders

GAAP-basis accounting for real estate assets utilizes historical cost accounting and assumes that real estate values diminish over time. In an effort to overcome the difference between real estate values and historical cost accounting for real estate assets, the Nareit Board of Governors established funds from operations as an improved measurement tool. Since its introduction, funds from operations has become a widely used non-GAAP financial measure among equity REITs. We believe that funds from operations is helpful to investors as an additional measure of the performance of an equity REIT. Moreover, we believe that funds from operations, as adjusted, allows investors to compare our performance to the performance of other real estate companies on a consistent basis, without having to account for differences recognized because of real estate acquisition and disposition decisions, financing decisions, capital structure, capital market transactions, variances resulting from the volatility of market conditions outside of our control, or other corporate activities that may not be representative of the operating performance of our properties.

The 2018 White Paper published by the Nareit Board of Governors (the "Nareit White Paper") defines funds from operations as net income (computed in accordance with GAAP), excluding gains or losses on sales of real estate, and impairments of real estate, plus depreciation and amortization of operating real estate assets, and after adjustments for our share of consolidated and unconsolidated partnerships and real estate joint ventures. Impairments represent the write-down of assets when fair value over the recoverability period is less than the carrying value due to changes in general market conditions and do not necessarily reflect the operating performance of the properties during the corresponding period.

We compute funds from operations, as adjusted, as funds from operations calculated in accordance with the Nareit White Paper, excluding significant gains, losses, and impairments realized on non-real estate investments, unrealized gains or losses on non-real estate investments, gains or losses on early extinguishment of debt, significant termination fees, acceleration of stock compensation expense due to the resignation of an executive officer, deal costs, the income tax effect related to such items, and the amount of such items that is allocable to our unvested restricted stock awards. Neither funds from operations nor funds from operations, as adjusted, should be considered as alternatives to net income (determined in accordance with GAAP) as indications of financial performance, or to cash flows from operating activities (determined in accordance with GAAP) as measures of liquidity, nor are they indicative of the availability of funds for our cash needs, including our ability to make distributions.

The following table reconciles net income to funds from operations for the share of consolidated real estate joint ventures attributable to noncontrolling interests and our share of unconsolidated real estate joint ventures:
Noncontrolling Interest Share of Consolidated Real Estate JVs Our Share of Unconsolidated
Real Estate JVs
June 30, 2022 June 30, 2022
(In thousands) Three Months Ended Six Months Ended Three Months Ended Six Months Ended
Net income $ 37,168 $ 69,345 $ 213 $ 433
Depreciation and amortization of real estate assets 26,418 50,099 934 1,889
Funds from operations $ 63,586 $ 119,444 $ 1,147 $ 2,322
Gross assets

Gross assets are calculated as total assets plus accumulated depreciation:
(In thousands) 6/30/22 3/31/22 12/31/21 9/30/21 6/30/21
Total assets $ 33,244,053 $ 32,844,256 $ 30,219,373 $ 28,558,718 $ 27,018,850
Accumulated depreciation 4,060,536 3,951,666 3,771,241 3,614,440 3,461,780
Gross assets $ 37,304,589 $ 36,795,922 $ 33,990,614 $ 32,173,158 $ 30,480,630
Initial stabilized yield (unlevered)

Initial stabilized yield is calculated as the estimated amounts of net operating income at stabilization divided by our investment in the property. Our initial stabilized yield excludes the benefit of leverage. Our cash rents related to our value-creation projects are generally expected to increase over time due to contractual annual rent escalations. Our estimates for initial stabilized yields, initial stabilized yields (cash basis), and total costs at completion represent our initial estimates at the commencement of the project. We expect to update this information upon completion of the project, or sooner if there are significant changes to the expected project yields or costs.
•Initial stabilized yield reflects rental income, including contractual rent escalations and any rent concessions over the term(s) of the lease(s), calculated on a straight-line basis.
•Initial stabilized yield (cash basis) reflects cash rents at the stabilization date after initial rental concessions, if any, have elapsed and our total cash investment in the property.

Definitions and Reconciliations (continued)
June 30, 2022
Investment-grade or publicly traded large cap tenants

Investment-grade or publicly traded large cap tenants represent tenants that are investment-grade rated or publicly traded companies with an average daily market capitalization greater than $10 billion for the twelve months ended June 30, 2022, as reported by Bloomberg Professional Services. Credit ratings from Moody's Investors Service and S&P Global Ratings reflect credit ratings of the tenant's parent entity, and there can be no assurance that a tenant's parent entity will satisfy the tenant's lease obligation upon such tenant's default. We monitor the credit quality and related material changes of our tenants. Material changes that cause a tenant's market capitalization to decrease below $10 billion, which are not immediately reflected in the twelve-month average, may result in their exclusion from this measure.

Investments

We hold investments in publicly traded companies and privately held entities primarily involved in the life science, agtech, and technology industries. We recognize, measure, present, and disclose these investments as follows:
Statements of Operations
Balance Sheet Gains and Losses
Carrying Amount Unrealized Realized
Difference between proceeds received upon disposition and historical cost
Publicly traded companies
Fair value Changes in fair value
Privately held entities without readily determinable fair values that:
Report NAV Fair value, using NAV as a practical expedient Changes in NAV, as a practical expedient to fair value
Do not report NAV
Cost, adjusted for observable price changes and impairments(1)
Observable price changes(1)
Impairments to reduce costs to fair value, which result in an adjusted cost basis and the differences between proceeds received upon disposition and adjusted or historical cost
Equity method investments
Contributions, adjusted for our share of the investee's earnings or losses, less distributions received, reduced by other-than-temporary impairments
Our share of unrealized gains or losses reported by the investee
Our share of realized gains or losses reported by the investee, and other-than-temporary impairments
(1)An observable price is a price observed in an orderly transaction for an identical or similar investment of the same issuer. Observable price changes result from, among other things, equity transactions for the same issuer with similar rights and obligations executed during the reporting period, including subsequent equity offerings or other reported equity transactions related to the same issuer.

Investments in real estate

The following table reconciles our investments in real estate as of June 30, 2022:
(In thousands) Investments in
Real Estate
Gross investments in real estate - North America $ 31,996,462
Less: accumulated depreciation - North America (4,056,183)
Net investments in real estate - North America 27,940,279
Net investments in real estate - Asia 12,652
Investments in real estate $ 27,952,931
Space Intentionally Blank
Definitions and Reconciliations (continued)
June 30, 2022
The square footage presented in the table below includes RSF of buildings in operation as of June 30, 2022, primarily representing lease expirations at recently acquired properties that also have inherent future development or redevelopment opportunities and for which we have the intent to demolish or redevelop the existing property upon expiration of the existing in-place leases and commencement of future construction:
Dev/
Redev
RSF of Lease Expirations Targeted for
Development and Redevelopment
Property/Submarket 2022 2023 Thereafter Total
Near-term projects:
40 Sylvan Road/Route 128 Redev - 312,845 - 312,845
275 Grove Street/Route 128 Redev 48,793 - 111,458
(1)
160,251
840 Winter Street/Route 128 Redev - 10,265 17,965 28,230
3825 Fabian Way/Greater Stanford Redev - 250,000 - 250,000
3301 Monte Villa Parkway/Bothell Redev 50,552 - - 50,552
Other/Texas Redev - - 143,105
(1)
143,105
99,345 573,110 272,528 944,983
Intermediate-term projects:
9444 Waples Street/Sorrento Mesa Dev 23,789 - 4,746 28,535
23,789 - 4,746 28,535
Future projects:
550 Arsenal Street/Cambridge/Inner Suburbs Dev - - 260,867
(1)
260,867
380 and 420 E Street/Seaport Innovation District Dev - - 195,506 195,506
Other/Greater Boston Redev - - 167,549
(1)
167,549
1122 El Camino Real/South San Francisco Dev - - 223,232 223,232
1150 El Camino Real/South San Francisco Dev - - 431,940
(1)
431,940
3875 Fabian Way/Greater Stanford Redev - - 228,000 228,000
960 Industrial Road/Greater Stanford Dev - - 110,000 110,000
219 East 42nd Street/New York City Dev - - 349,947 349,947
10975 and 10995 Torreyana Road/Torrey Pines Dev - - 84,829 84,829
4161 Campus Point Court/University Town Center Dev - 159,884 - 159,884
10260 Campus Point Drive/University Town Center Dev - 109,164 - 109,164
Sequence District by Alexandria/Sorrento Mesa Dev/Redev - - 689,938 689,938
4025 and 4045 Sorrento Valley Boulevard/Sorrento Valley Dev 10,926 - 11,960
(1)
22,886
601 Dexter Avenue North/Lake Union Dev - 18,680 - 18,680
830 4th Avenue South/SoDo Dev - - 42,380
(1)
42,380
Other/Seattle Dev - 92,205 10,232
(1)
102,437
10,926 379,933 2,806,380 3,197,239
134,060 953,043 3,083,654 4,170,757
(1)Includes vacant square footage as of June 30, 2022.
Joint venture financial information

We present components of balance sheet and operating results information related to our real estate joint ventures, which are not presented, or intended to be presented, in accordance with GAAP. We present the proportionate share of certain financial line items as follows: (i) for each real estate joint venture that we consolidate in our financial statements, which are controlled by us through contractual rights or majority voting rights, but of which we own less than 100%, we apply the noncontrolling interest economic ownership percentage to each financial item to arrive at the amount of such cumulative noncontrolling interest share of each component presented; and (ii) for each real estate joint venture that we do not control and do not consolidate, and are instead controlled jointly or by our joint venture partners through contractual rights or majority voting rights, we apply our economic ownership percentage to each financial item to arrive at our proportionate share of each component presented.

The components of balance sheet and operating results information related to our real estate joint ventures do not represent our legal claim to those items. For each entity that we do not wholly own, the joint venture agreement generally determines what equity holders can receive upon capital events, such as sales or refinancing, or in the event of a liquidation. Equity holders are normally entitled to their respective legal ownership of any residual cash from a joint venture only after all liabilities, priority distributions, and claims have been repaid or satisfied.

We believe that this information can help investors estimate the balance sheet and operating results information related to our partially owned entities. Presenting this information provides a perspective not immediately available from consolidated financial statements and one that can supplement an understanding of the joint venture assets, liabilities, revenues, and expenses included in our consolidated results.

The components of balance sheet and operating results information related to our real estate joint ventures are limited as an analytical tool as the overall economic ownership interest does not represent our legal claim to each of our joint ventures' assets, liabilities, or results of operations. In addition, joint venture financial information may include financial information related to the unconsolidated real estate joint ventures that we do not control. We believe that in order to facilitate for investors a clear understanding of our operating results and our total assets and liabilities, joint venture financial information should be examined in conjunction with our consolidated statements of operations and balance sheets. Joint venture financial information should not be considered an alternative to our consolidated financial statements, which are presented and prepared in accordance with GAAP.

Definitions and Reconciliations (continued)
June 30, 2022
Key items included in net income attributable to Alexandria's common stockholders

We present a tabular comparison of items, whether gain or loss, that may facilitate a high-level understanding of our results and provide context for the disclosures included in this Supplemental Information, our most recent annual report on Form 10-K, and our subsequent quarterly reports on Form 10-Q. We believe that such tabular presentation promotes a better understanding for investors of the corporate-level decisions made and activities performed that significantly affect comparison of our operating results from period to period. We also believe that this tabular presentation will supplement for investors an understanding of our disclosures and real estate operating results. Gains or losses on sales of real estate and impairments of held for sale assets are related to corporate-level decisions to dispose of real estate. Gains or losses on early extinguishment of debt are related to corporate-level financing decisions focused on our capital structure strategy. Significant realized and unrealized gains or losses on non-real estate investments and impairments of real estate and non-real estate investments are not related to the operating performance of our real estate assets as they result from strategic, corporate-level non-real estate investment decisions and external market conditions. Impairments of non-real estate investments are not related to the operating performance of our real estate as they represent the write-down of non-real estate investments when their fair values decrease below their respective carrying values due to changes in general market or other conditions outside of our control. Significant items, whether a gain or loss, included in the tabular disclosure for current periods are described in further detail in this Supplemental Information and accompanying Earnings Press Release.

Mega campus

Mega campuses are cluster campuses that consist of approximately 1 million RSF or more, including operating, active development/redevelopment, and land RSF less operating RSF expected to be demolished. The following table reconciles our operating RSF as of June 30, 2022:

Operating RSF
Mega campus 27,046,236
Non-mega campus 14,037,293
Total 41,083,529
Mega campus RSF as a percentage of total operating property RSF 66 %

Net cash provided by operating activities after dividends

Net cash provided by operating activities after dividends includes the deduction for distributions to noncontrolling interests. For purposes of this calculation, changes in operating assets and liabilities are excluded as they represent timing differences.

Net debt and preferred stock to Adjusted EBITDA

Net debt and preferred stock to Adjusted EBITDA is a non-GAAP financial measure that we believe is useful to investors as a supplemental measure of evaluating our balance sheet leverage. Net debt and preferred stock is equal to the sum of total consolidated debt less cash, cash equivalents, and restricted cash, plus preferred stock outstanding as of the end of the period. Refer to the definition of Adjusted EBITDA and Adjusted EBITDA margin for further information on the calculation of Adjusted EBITDA.

The following table reconciles debt to net debt and preferred stock and computes the ratio to Adjusted EBITDA:
(Dollars in thousands) 6/30/22 3/31/22 12/31/21 9/30/21 6/30/21
Secured notes payable $ 24,986 $ 208,910 $ 205,198 $ 198,758 $ 227,984
Unsecured senior notes payable 10,096,462 10,094,337 8,316,678 8,314,851 8,313,025
Unsecured senior line of credit and commercial paper 149,958 - 269,990 749,978 299,990
Unamortized deferred financing costs 78,978 81,175 65,476 65,112 66,913
Cash and cash equivalents (420,258) (775,060) (361,348) (325,872) (323,876)
Restricted cash (97,404) (95,106) (53,879) (42,182) (33,697)
Preferred stock - - - - -
Net debt and preferred stock $ 9,832,722 $ 9,514,256 $ 8,442,115 $ 8,960,645 $ 8,550,339
Adjusted EBITDA:
- quarter annualized $ 1,797,488 $ 1,734,956 $ 1,631,244 $ 1,557,652 $ 1,483,576
- trailing 12 months $ 1,680,335 $ 1,601,857 $ 1,517,838 $ 1,442,929 $ 1,371,586
Net debt and preferred stock to Adjusted EBITDA:
- quarter annualized 5.5 x 5.5 x 5.2 x 5.8 x 5.8 x
- trailing 12 months 5.9 x 5.9 x 5.6 x 6.2 x 6.2 x

Space Intentionally Blank

Definitions and Reconciliations (continued)
June 30, 2022
Net operating income, net operating income (cash basis), and operating margin

The following table reconciles net income to net operating income and net operating income (cash basis) and computes operating margin:
Three Months Ended Six Months Ended
(Dollars in thousands) 6/30/22 6/30/21 6/30/22 6/30/21
Net income $ 309,382 $ 404,520 $ 191,990 $ 430,053
Equity in earnings of unconsolidated real estate joint ventures (213) (2,609) (433) (6,146)
General and administrative expenses
43,397 37,880 84,328 71,876
Interest expense 24,257 35,158 53,697 71,625
Depreciation and amortization
242,078 190,052 482,737 370,965
Impairment of real estate
-

4,926 - 10,055
Loss on early extinguishment of debt
3,317 - 3,317 67,253
Gain on sales of real estate (214,219) - (214,219) (2,779)
Investment loss (income) 39,481 (304,263) 279,800 (305,277)
Net operating income 447,480 365,664 881,217 707,625
Straight-line rent revenue
(27,362) (27,903) (69,387) (55,285)
Amortization of acquired below-market leases
(16,760) (13,267) (30,675) (25,379)
Net operating income (cash basis) $ 403,358 $ 324,494 $ 781,155 $ 626,961
Net operating income (cash basis) - annualized
$ 1,613,432 $ 1,297,976 $ 1,562,310 $ 1,253,922
Net operating income (from above) $ 447,480 $ 365,664 $ 881,217 $ 707,625
Total revenues $ 643,764 $ 509,619 $ 1,258,829 $ 989,468
Operating margin 70% 72% 70% 72%

Net operating income is a non-GAAP financial measure calculated as net income, the most directly comparable financial measure calculated and presented in accordance with GAAP, excluding equity in the earnings of our unconsolidated real estate joint ventures, general and administrative expenses, interest expense, depreciation and amortization, impairments of real estate, gains or losses on early extinguishment of debt, gains or losses on sales of real estate, and investment income or loss. We believe net operating income provides useful information to investors regarding our financial condition and results of operations because it primarily reflects those income and expense items that are incurred at the property level. Therefore, we believe net operating income is a useful measure for investors to evaluate the operating performance of our consolidated real estate assets. Net operating income on a cash basis is net operating income adjusted to exclude the effect of straight-line rent and amortization of acquired above- and below-market lease revenue adjustments required by GAAP. We believe that net operating income on a cash basis is helpful to investors as an additional measure of operating performance because it eliminates straight-line rent revenue and the amortization of acquired above- and below-market leases.

Furthermore, we believe net operating income is useful to investors as a performance measure of our consolidated properties because, when compared across periods, net operating income reflects trends in occupancy rates, rental rates, and operating costs, which provide a perspective not immediately apparent from net income or loss. Net operating income can be used to measure the initial stabilized yields of our properties by calculating net operating income generated by a property divided by our investment in the property. Net operating income excludes certain components from net income in order to provide results that are more closely related to the results of operations of our properties. For example, interest expense is not necessarily linked to the operating performance of a real estate asset and is often incurred at the corporate level rather than at the property level. In addition, depreciation and amortization, because of historical cost accounting and useful life estimates, may distort comparability of operating performance at the property level. Impairments of real estate have been excluded in deriving net operating income because we do not consider impairments of real estate to be property-level operating expenses. Impairments of real estate relate to changes in the values of our assets and do not reflect the current operating performance with respect to related revenues or expenses. Our impairments of real estate represent the write-down in the value of the assets to the estimated fair value less cost to sell. These impairments result from investing decisions or a deterioration in market conditions. We also exclude realized and unrealized investment gain or loss, which results from investment decisions that occur at the corporate level related to non-real estate investments in publicly traded companies and certain privately held entities. Therefore, we do not consider these activities to be an indication of operating performance of our real estate assets at the property level. Our calculation of net operating income also excludes charges incurred from changes in certain financing decisions, such as losses on early extinguishment of debt, as these charges often relate to corporate strategy. Property operating expenses included in determining net operating income primarily consist of costs that are related to our operating properties, such as utilities, repairs, and maintenance; rental expense related to ground leases; contracted services, such as janitorial, engineering, and landscaping; property taxes and insurance; and property-level salaries. General and administrative expenses consist primarily of accounting and corporate compensation, corporate insurance, professional fees, office rent, and office supplies that are incurred as part of corporate office management. We calculate operating margin as net operating income divided by total revenues.

We believe that in order to facilitate for investors a clear understanding of our operating results, net operating income should be examined in conjunction with net income or loss as presented in our consolidated statements of operations. Net operating income should not be considered as an alternative to net income or loss as an indication of our performance, nor as an alternative to cash flows as a measure of our liquidity or our ability to make distributions.

Operating statistics

We present certain operating statistics related to our properties, including number of properties, RSF, occupancy percentage, leasing activity, and contractual lease expirations as of the end of the period. We believe these measures are useful to investors because they facilitate an understanding of certain trends for our properties. We compute the number of properties, RSF, occupancy percentage, leasing activity, and contractual lease expirations at 100% for all properties in which we have an investment, including properties owned by our consolidated and unconsolidated real estate joint ventures. For operating metrics based on annual rental revenue, refer to the definition of annual rental revenue herein.

Definitions and Reconciliations (continued)
June 30, 2022
Same property comparisons

As a result of changes within our total property portfolio during the comparative periods presented, including changes from assets acquired or sold, properties placed into development or redevelopment, and development or redevelopment properties recently placed into service, the consolidated total income from rentals, as well as rental operating expenses in our operating results, can show significant changes from period to period. In order to supplement an evaluation of our results of operations over a given quarterly or annual period, we analyze the operating performance for all consolidated properties that were fully operating for the entirety of the comparative periods presented, referred to as same properties. We separately present quarterly and year-to-date same property results to align with the interim financial information required by the SEC in our management's discussion and analysis of our financial condition and results of operations. These same properties are analyzed separately from properties acquired subsequent to the first day in the earliest comparable quarterly or year-to-date period presented, properties that underwent development or redevelopment at any time during the comparative periods, unconsolidated real estate joint ventures, properties classified as held for sale, and corporate entities (legal entities performing general and administrative functions), which are excluded from same property results. Additionally, termination fees, if any, are excluded from the results of same properties.

Space Intentionally Blank
The following table reconciles the number of same properties to total properties for the six months ended June 30, 2022:
Redevelopment - placed into
Development - under construction Properties
service after January 1, 2021
Properties
5 and 9 Laboratory Drive 2 700 Quince Orchard Road 1
4 Davis Drive 1 3160 Porter Drive 1
201 Brookline Avenue 1 5505 Morehouse Drive 1
10055 Barnes Canyon Road 1 Other 1
15 Necco Street 1 4
751 Gateway Boulevard 1
325 Binney Street 1
Acquisitions after January 1, 2021
Properties
1150 Eastlake Avenue East 1 3301, 3303, 3305, 3307, 3420, and 3440 Hillview Avenue 6
10102 Hoyt Park Drive 1
9810 Darnestown Road 1 Sequence District by Alexandria 5
99 Coolidge Avenue 1
Alexandria Center® for Life Science - Fenway
1
500 North Beacon Street and 4 Kingsbury Avenue 2
550 Arsenal Street 1
9808 Medical Center Drive 1 1501-1599 Industrial Road 6
6040 George Watts Hill Drive 1 One Investors Way 2
16 2475 Hanover Street 1
Development - placed into
10975 and 10995 Torreyana Road 2
service after January 1, 2021
Properties Pacific Technology Park 6
1165 Eastlake Avenue East 1 1122 and 1150 El Camino Real 2
201 Haskins Way 1 12 Davis Drive 1
825 and 835 Industrial Road 2 7360 Carroll Road 1
9950 Medical Center Drive 1 8505 Costa Verde Boulevard and 4260 Nobel Drive 2
3115 Merryfield Row 1
8 and 10 Davis Drive 2 225 and 235 Presidential Way 2
8 104 TW Alexander Drive 4
Redevelopment - under construction Properties One Hampshire Street 1
30-02 48th Avenue 1 Intersection Campus 12
The Arsenal on the Charles 11 Other 48
2400 Ellis Road, 40 and 41 Moore Drive, and 14 TW Alexander Drive 4 103
Unconsolidated real estate JVs 4
840 Winter Street 1 Properties held for sale 1
20400 Century Boulevard 1
9601 and 9603 Medical Center Drive 2 Total properties excluded from same properties 170
One Rogers Street 1
40, 50, and 60 Sylvan Road 3 Same properties 266
Alexandria Center® for Advanced Technologies - Monte Villa Parkway
6
Total properties in North America as of June 30, 2022
436
651 Gateway Boulevard 1
8800 Technology Forest Place 1
Other 2
34
Definitions and Reconciliations (continued)
June 30, 2022
Stabilized occupancy date

The stabilized occupancy date represents the estimated date on which the project is expected to reach occupancy of 95% or greater.

Tenant recoveries

Tenant recoveries represent revenues comprising reimbursement of real estate taxes, insurance, utilities, repairs and maintenance, common area expenses, and other operating expenses and earned in the period during which the applicable expenses are incurred and the tenant's obligation to reimburse us arises.

We classify rental revenues and tenant recoveries generated through the leasing of real estate assets within revenue in income from rentals in our consolidated statements of operations. We provide investors with a separate presentation of rental revenues and tenant recoveries in "Same Property Performance" of this Supplemental Information because we believe it promotes investors' understanding of our operating results. We believe that the presentation of tenant recoveries is useful to investors as a supplemental measure of our ability to recover operating expenses under our triple net leases, including recoveries of utilities, repairs and maintenance, insurance, property taxes, common area expenses, and other operating expenses, and of our ability to mitigate the effect to net income for any significant variability to components of our operating expenses.

The following table reconciles income from rentals to tenant recoveries:
Three Months Ended Six Months Ended
(In thousands) 6/30/22 3/31/22 12/31/21 9/30/21 6/30/21 6/30/22 6/30/21
Income from rentals $ 640,959 $ 612,554 $ 574,656 $ 546,527 $ 508,371 $ 1,253,513 $ 987,066
Rental revenues (485,067) (469,537) (435,637) (415,918) (396,804) (954,604) (767,037)
Tenant recoveries $ 155,892 $ 143,017 $ 139,019 $ 130,609 $ 111,567 $ 298,909 $ 220,029

Total equity capitalization

Total equity capitalization is equal to the outstanding shares of common stock multiplied by the closing price on the last trading day at the end of each period presented.

Total market capitalization

Total market capitalization is equal to the sum of total equity capitalization and total debt.

Unencumbered net operating income as a percentage of total net operating income

Unencumbered net operating income as a percentage of total net operating income is a non-GAAP financial measure that we believe is useful to investors as a performance measure of the results of operations of our unencumbered real estate assets as it reflects those income and expense items that are incurred at the unencumbered property level. Unencumbered net operating income is derived from assets classified in continuing operations, which are not subject to any mortgage, deed of trust, lien, or other security interest, as of the period for which income is presented.

The following table summarizes unencumbered net operating income as a percentage of total net operating income:
Three Months Ended
(Dollars in thousands)
6/30/22 3/31/22 12/31/21 9/30/21 6/30/21
Unencumbered net operating income
$ 446,473 $ 420,960 $ 390,017 $ 371,026 $ 353,104
Encumbered net operating income
1,007 12,777 11,189 10,738 12,560
Total net operating income $ 447,480 $ 433,737 $ 401,206 $ 381,764 $ 365,664
Unencumbered net operating income as a percentage of total net operating income
100% 97% 97% 97% 97%

Weighted-average interest rate for capitalization of interest

The weighted-average interest rate required for calculating capitalization of interest pursuant to GAAP represents a weighted-average rate as of the end of the applicable period, based on the rates applicable to borrowings outstanding during the period, including expense/income related to interest rate hedge agreements, amortization of loan fees, amortization of debt premiums (discounts), and other bank fees. A separate calculation is performed to determine our weighted-average interest rate for capitalization for each month. The rate will vary each month due to changes in variable interest rates, outstanding debt balances, the proportion of variable-rate debt to fixed-rate debt, the amount and terms of interest rate hedge agreements, and the amount of loan fee and premium (discount) amortization.

Space Intentionally Blank
Definitions and Reconciliations (continued)
June 30, 2022
Weighted-average shares of common stock outstanding - diluted

From time to time, we enter into capital market transactions, including forward equity sales agreements ("Forward Agreements"), to fund acquisitions, to fund construction of our highly leased development and redevelopment projects, and for general working capital purposes. We are required to consider the potential dilutive effect of our forward equity sales agreements under the treasury stock method while the forward equity sales agreements are outstanding. As of June 30, 2022, we had Forward Agreements outstanding to sell an aggregate of 9.0 million shares of common stock.

The weighted-average shares of common stock outstanding used in calculating EPS - diluted, FFO per share - diluted, and FFO per share - diluted, as adjusted, during each period are calculated as follows:
Three Months Ended Six Months Ended
(In thousands) 6/30/22 3/31/22 12/31/21 9/30/21 6/30/21 6/30/22 6/30/21
Basic shares for earnings per share 161,412 158,198 153,464 150,854 145,825 159,814 141,596
Forward Agreements - - 843 707 233 - 300
Diluted shares for earnings per share 161,412 158,198 154,307 151,561 146,058 159,814 141,896
Basic shares for funds from operations per share and funds from operations per share, as adjusted 161,412 158,198 153,464 150,854 145,825 159,814 141,596
Forward Agreements - 11 843 707 233 - 300
Diluted shares for funds from operations per share and funds from operations per share, as adjusted 161,412 158,209 154,307 151,561 146,058 159,814 141,896