Material Agreement - Form 8-K

On February 13, 2024, Codexis, Inc. (the "Company") entered into a loan and security agreement (the "Loan Agreement") with Innovatus Life Sciences Lending Fund I, LP, a Delaware limited partnership ("Innovatus") as collateral agent and the Lenders listed on Schedule 1.1 thereto, pursuant to which Innovatus, as a Lender, has agreed to make certain term loans to the Company in the aggregate principal amount of up to $40.0 million (the "Term Loans"). Funding of the first $30.0 million tranche was completed on February 13, 2024. The Company will be eligible to draw on a second tranche of $10.0 million upon achievement of certain milestones, including the achievement of certain trailing twelve month net product revenue and certain ratio of Indebtedness (as defined in the Loan Agreement) to its then Market Capitalization (as defined in the Loan Agreement).

The Company is entitled to make interest-only payments for thirty-sixmonths, or up to forty-eight months if certain conditions are met. The Term Loans will mature on the 5th anniversary of the initial funding date, and will bear interest at a floating rate of the sum of (a) the greater of (i) Primate Rate (as defined in the Loan Agreement) and (ii) 7.50%, plus (b) 3.25%.

The Loan Agreement is secured by substantially all assets of the Company. Proceeds will be used for working capital purposes and to fund Company's general business requirements. The Loan Agreement contains customary representations and warranties and covenants, subject to customary carve outs, and includes financial covenants related to liquidity and net product revenue, with the latter beginning with the period ending September 30, 2024.

In connection with the Term Loans, the Company is required to issue to Innovatus a warrant (the "Warrants") to purchase an aggregate of 424,028 shares of the Company's common stock at an exercise price of $2.83 per share. The Warrants may be exercised on a cashless basis, and are immediately exercisable through the 10th anniversary of the initial funding date. The number of shares of common stock for which each Warrant is exercisable and the associated exercise price are subject to certain proportional adjustments as set forth in such Warrant.

The descriptions of the Loan Agreement and the Warrants contained herein do not purport to be complete and are qualified in their entirety by reference to the complete text of the Loan Agreement which will be filed as an exhibit to the Company's Annual Report on Form 10-Kfor the year ended December 31, 2023, and the form of Warrant filed as Exhibit 4.1 attached hereto.