Shimadzu Corporation

04/18/2023 | Press release | Distributed by Public on 04/17/2023 22:09

One-Step, Efficient Evaluation of the Thermal Stability of Nucleic Acid PharmaceuticalsRelease of Tm Analysis System, which Achieves the Highest Level of Data Reliability in[...]

Tm analysis serves an important role in checking the thermal stability and sequence of nucleic acids. In Tm analysis, heat is applied to the nucleic acids in double-strands. Then, the change in absorbance (melting curve) that occurs as the temperature increases and the strands dissociate into single strands is measured. The melting temperature (Tm value) is determined as the temperature where the mole fractions of single and double strands are equal.