Additional Proxy Soliciting Materials - Form DEFA14A

Preliminary Proxy Statement

Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

Definitive Proxy Statement

Definitive Additional Materials

Soliciting Material Pursuant to §240.14a-12

No fee required.

Fee paid previously with preliminary materials.

Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.

  P.O. BOX 8016, CARY, NC 27512-9903

Cabaletta Bio, Inc.

Annual Meeting of Stockholders

Monday, June 3, 2024 at 9:00 AM, Eastern Time

Annual Meeting to be held live via the internet - please visit www.proxydocs.com/CABA for more details

You must pre-register to attend the meeting online at www.proxydocs.com/CABA

For a convenient way to view proxy materials, VOTE, and obtain directions to attend the meeting go to www.proxydocs.com/CABA

To vote your proxy while visiting this site, you will need the 12 digit control number in the box below.

This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. This is not a ballot. You cannot use this notice to vote your shares. We encourage you to access and review all of the important information contained in the proxy materials before voting.

Under United States Securities and Exchange Commission rules, proxy materials do not have to be delivered in paper. Proxy materials can be distributed by making them available on the Internet.

If you want to receive a paper or e-mail copy of the proxy material, you must request one. There is no charge to you for requesting a copy. In order to receive a paper package in time for this year's meeting, you must make this request on or before May 24, 2024.

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Meeting Materials: Notice of Meeting and Proxy Statement & Annual Report or Form 10-K

Important Notice Regarding the Availability of Proxy Materials for the Stockholders Meeting To Be Held On June 3, 2024 For Stockholders of record as of April 4, 2024

To order paper materials, use one of the following methods.

Internet:

www.investorelections.com/CABA

Call:

1-866-648-8133

Email:

[email protected]

* If requesting material by e-mail, please send a blank e-mail with the 12 digit control number (located below) in the subject line. No other requests, instructions OR other inquiries should be included with your e-mail requesting material.

Have the 12 digit control number located in the

box above available when you access the

website and follow the instructions.

PROPOSAL