NIST - National Institute of Standards and Technology

07/09/2024 | Press release | Distributed by Public on 07/10/2024 03:12

Metabolomics 2023 Workshop Report: Moving Toward Consensus on Best QA/QC Practices in LC MS Based Untargeted Metabolomics

Published
July 9, 2024

Author(s)

Tracey Schock, Jonathan Mosley, Warwick Dunn, Julia Kuligowski, Matthew Lewis, Maria Monge, Candice Ulmer Holland, Dajana Vuckovic, Krista Zanetti

Abstract

Introduction: During the Metabolomics 2023 conference, the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) presented a workshop focusing on key quality assurance and quality control (QA/QC) topic categories for LC-MS-based untargeted metabolomics. This is the second workshop in a series presented at consecutive Metabolomics Society conferences. Objectives: The mQACC Best Practices Working Group aimed to disseminate recent findings from forums examining four key QA/QC areas with respect to untargeted LC-MS-based metabolomics and discuss which aspects to include in a living guidance document. Methods: Presentations of four topics, focusing on reference materials, data quality review, metabolite identification/annotation and QA were given. Live polling and a short discussion occurred immediately following each presentation. A discussion regarding the living guidance document concluded the session. Results: Enthusiastic participation in polls and follow-up discussions provided additional data that offered a broad international perspective on QA/QC practices. Conclusions: Community input gathered from this workshop series is being used to shape the living guidance document, which aims to be a continually evolving QA/QC best practices resource for metabolomics researchers.
Citation
Metabolomics
Pub Type
Journals

Keywords

metabolomics, quality control (QC) samples, Liquid Chromatography-Mass Spectrometry (LC-MS), metabolite annotation, metabolite identification, reference materials, data quality, quality assurance

Citation

Schock, T. , Mosley, J. , Dunn, W. , Kuligowski, J. , Lewis, M. , Monge, M. , Ulmer Holland, C. , Vuckovic, D. and Zanetti, K. (2024), Metabolomics 2023 Workshop Report: Moving Toward Consensus on Best QA/QC Practices in LC-MS-Based Untargeted Metabolomics, Metabolomics, [online], https://doi.org/10.1007/s11306-024-02135-w, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=957658 (Accessed July 10, 2024)

Additional citation formats

Issues

If you have any questions about this publication or are having problems accessing it, please contact [email protected].