04/04/2024 | Press release | Distributed by Public on 04/04/2024 10:28
Clinical and real-world evidence presentations highlight how the Company is transforming care for patients who are fighting some of the most common and devastating cardiovascular diseases
NEW BRUNSWICK, NJ (April 4, 2024) - Johnson & Johnson announced today that clinical and real-world evidence from its cardiovascular portfolio will be featured at the American College of Cardiology 73rd Annual Scientific Session & Expo (ACC.24) taking place April 6-8, 2024, in Atlanta, Georgia. Eleven abstracts, including five oral presentations, will showcase data from Company-sponsored studies demonstrating therapeutic benefit of breakthrough medicines, such as XARELTO® (rivaroxaban), and interventional technologies, such as those from Abiomed® and Biosense Webster®, to help treat cardiovascular diseases, including atrial fibrillation (AF) and peripheral artery disease (PAD).
"Cardiovascular disease remains the leading cause of death for adults worldwide and millions more may be at risk of stroke and other life-threatening cardiovascular conditions as the population ages.1 As a global leader in healthcare, we are determined to improve these statistics and empower those living with cardiovascular disease to lead fuller, healthier lives," said Katie Devine, President, US General Medicines, Canada and Puerto Rico, Johnson & Johnson Innovative Medicine. "At ACC.24, we look forward to sharing the latest research and innovation from our broad portfolio, including XARELTO®, to equip clinicians and researchers with knowledge and insights that can help transform cardiovascular care for all."
Improving the outlook for people with cardiovascular disease
Johnson & Johnson is committed to elevating the standard of care in cardiovascular diseases and unlocking the potential of medicines and solutions of tomorrow. Several data presentations at ACC.24 demonstrate how the Company is improving outcomes for people living with cardiovascular disease, including older adults and other patient populations often considered hard to treat. These include:
"Our advancements have changed how cardiovascular diseases are diagnosed and treated and have had a meaningful impact on the lives of millions of patients and families. The data we're presenting at ACC.24 demonstrate how we're continuing to deliver on our commitment," said Tim Schmid, Executive Vice President and Worldwide Chairman, Johnson & Johnson MedTech. "We are intent on elevating the standard of care in cardiovascular diseases and, with our partners, are leading research in areas like nonvalvular AF, stroke, and acute coronary syndrome. The real-world and clinical evidence presented at ACC.24 will provide cardiology teams with critical information to help deliver improved care for their patients."
The list of Company-sponsored abstracts follows:
XARELTO® (rivaroxaban) |
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Oral sessions |
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Abstract #903-04 |
Efficacy and Safety of Dual Antiplatelet Therapy After Peripheral Artery Revascularization: Insights from VOYAGER PAD |
Abstract #903-10 |
Risk of Adverse Events in Peripheral Artery Disease Patients with Below-Knee Disease: An Analysis from the VOYAGER-PAD Catheter-Based Angiographic Core Lab |
Abstract #903-12 |
Risk Stratification for Amputation in Patients with Symptomatic PAD After Lower Extremity Revascularization: Insights from VOYAGER PAD |
Abstract #906-04 |
Effect of Rivaroxaban on Bleeding or Ischemic Event and Rehospitalization Among Elderly or Non-Elderly Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: Insights from the PIONEER AF-PCI Trial |
Poster session |
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Abstract #1403-154 |
Efficacy of Rivaroxaban in Reducing Coronary or Peripheral Hospitalizations According to Smoking Status: A Post Hoc Analysis of the VOYAGER PAD Trial |
Biosense Webster |
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Oral session |
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Abstract #916-10 |
Scar Burden and Outcomes in Paroxysmal Atrial Fibrillation in the REAL-AF Registry |
Poster sessions |
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Abstract #1293-202 |
Left Atrial Volume Index and Scar Burden are Not Associated with Recurrence After Persistent Atrial Fibrillation Ablation |
Abstract #1293-203 |
Patients with Severe Left Atrial Scar Burden May Benefit from More Extensive Ablation |
Abstract #1511-205 |
Utilization of ICE vs TEE and Recurrence of Arrhythmias at 12 Months Post-Ablation in Paroxysmal (PAF) and Persistent Atrial Fibrillation (PSAF) in the REAL-AF Registry |
Abiomed |
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Late Breaking Clinical Trial |
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Abstract #406-14 |
Percutaneous Transvalvular Micro-axial Flow Pump in Infarct Related Cardiogenic Shock. Results of The Danger-shock Trial. |
Population Health |
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Poster session |
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Abstract #1044-05 |
Neighborhood Health Predicts Peripheral Artery Disease Outcomes After Controlling for Quality of Medical Care: A Cohort Analysis Applying the Area Deprivation Index |
About XARELTO® (rivaroxaban)
XARELTO® is a prescription medicine used to:
XARELTO® is used with low dose aspirin to:
XARELTO® is used in children to:
XARELTO® was not studied and is not recommended in children less than 6 months of age who:
IMPORTANT SAFETY INFORMATION
WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT XARELTO®?
XARELTO® may cause serious side effects, including:
Do not stop taking XARELTO® without talking to the doctor who prescribes it for you. Stopping XARELTO® increases your risk of having a stroke. If you have to stop taking XARELTO®, your doctor may prescribe another blood thinner medicine to prevent a blood clot from forming.
You may have a higher risk of bleeding if you take XARELTO® and take other medicines that increase your risk of bleeding, including:
Tell your doctor if you take any of these medicines. Ask your doctor or pharmacist if you are not sure if your medicine is one listed above.
Call your doctor or get medical help right away if you or your child develop any of these signs or symptoms of bleeding:
Unexpected bleeding or bleeding that lasts a long time, such as:
Spinal or epidural blood clots (hematoma). People who take a blood thinner medicine (anticoagulant) like XARELTO®, and have medicine injected into their spinal and epidural area, or have a spinal puncture, have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis). Your risk of developing a spinal or epidural blood clot is higher if:
If you take XARELTO® and receive spinal anesthesia or have a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots.
Tell your doctor right away if you have:
XARELTO® is not for use in people with artificial heart valves.
XARELTO® is not for use in people with antiphospholipid syndrome (APS), especially with positive triple antibody testing.
Do not take XARELTO® if you or your child:
Before taking XARELTO®, tell your doctor about all your medical conditions, including if you or your child:
Are pregnant or plan to become pregnant. It is not known if XARELTO® will harm your unborn baby.
Tell all of your doctors and dentists that you or your child are taking XARELTO®. They should talk to the doctor who prescribed XARELTO® for you before you have any surgery, medical or dental procedure.
Tell your doctor about all the medicines you or your child take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Some of your other medicines may affect the way XARELTO® works, causing side effects. Certain medicines may increase your risk of bleeding. See "What is the most important information I should know about XARELTO®?"
HOW SHOULD I TAKE XARELTO®?
If you take XARELTO® for:
Atrial Fibrillation that is not caused by a heart valve problem:
Blood clots in the veins of your legs or lungs:
If you miss a dose:
Hip or knee replacement surgery:
Blood clots in people hospitalized for an acute illness:
Reducing the risk of serious heart problems, heart attack and stroke in coronary artery disease:
Reducing the risk of a sudden decrease in blood flow to the legs, major amputation, serious heart problems or stroke in people with peripheral artery disease, including those who have recently had a procedure to improve blood flow to the legs:
For children who take XARELTO®:
If your child vomits or spits up:
If your child misses a dose:
WHAT ARE THE POSSIBLE SIDE EFFECTS OF XARELTO®?
XARELTO® may cause serious side effects:
The most common side effect of XARELTO® in adults was bleeding.
The most common side effects of XARELTO® in children include:
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects to Janssen Pharmaceuticals, Inc., at 1-800-JANSSEN (1-800-526-7736).
Please read full Prescribing Information, including Boxed Warnings, and Medication Guide for XARELTO®.
Trademarks are those of their respective owners. Janssen and Bayer together are developing rivaroxaban.
About Johnson & Johnson
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.
Learn more at https://www.jnj.com/ or at www.janssen.com/johnson-johnson-innovative-medicine. Janssen Research & Development, LLC, Janssen Biotech, Inc. and Janssen Pharmaceuticals, Inc. are Johnson & Johnson companies.
Cautions Concerning Forward-Looking Statements
This press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995 regarding product development and the potential benefits and treatment impact of rivaroxaban. The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of Janssen Research & Development, LLC, Janssen Biotech, Inc., Janssen Pharmaceuticals, Inc. and/or Johnson & Johnson. Risks and uncertainties include, but are not limited to: challenges and uncertainties inherent in product research and development, including the uncertainty of clinical success and of obtaining regulatory approvals; uncertainty of commercial success; manufacturing difficulties and delays; competition, including technological advances, new products and patents attained by competitors; challenges to patents; product efficacy or safety concerns resulting in product recalls or regulatory action; changes in behavior and spending patterns of purchasers of health care products and services; changes to applicable laws and regulations, including global health care reforms; and trends toward health care cost containment. A further list and descriptions of these risks, uncertainties and other factors can be found in Johnson & Johnson's Annual Report on Form 10-K for the fiscal year ended December 31, 2023, including in the sections captioned "Cautionary Note Regarding Forward-Looking Statements" and "Item 1A. Risk Factors," and in Johnson & Johnson's subsequent Quarterly Reports on Form 10-Q and other filings with the Securities and Exchange Commission. Copies of these filings are available online at www.sec.gov, www.jnj.com or on request from Johnson & Johnson. None of Janssen Research & Development, LLC, Janssen Biotech, Inc., Janssen Pharmaceuticals, Inc. nor Johnson & Johnson undertake to update any forward-looking statement as a result of new information or future events or developments.
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Media contact:
Tesia Williams
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202-809-4599
Investor contact:
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1 World Health Organization. Cardiovascular diseases (CVDs). 2021. Accessed February 15, 2024. Available at: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds).