Explanation of Responses:
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1. Shares were sold pursuant to a Rule 10b5-1 trading plan.
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2. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $53.37 to $54.27 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
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3. reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
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4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $56.18 to $57.16 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
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5. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $57.18 to $57.99 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
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6. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $55.69 to $56.67 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
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7. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $56.69 to $57.67 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
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8. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $57.68 to $58.56 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
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9. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $58.68 to $59.67 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
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10. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $59.70 to $59.78 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
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11. The reported securities are held directly by Omega Fund V, L.P. ('Omega V'). The reported securities may be deemed to be beneficially owned by each of Omega Fund V GP, L.P. ('Omega V GP'), as the general partner of Omega V, and Omega Fund V GP Manager, Ltd. ('Omega V GP Manager'), as the general partner of Omega V GP. Otello Stampacchia, Anne-Mari Paster and Claudio Nessi (the 'Omega Directors') are all the shareholders and directors of Omega V GP Manager and have shared voting and investment power over the shares held by Omega V. Each of Omega V GP, Omega Fund V GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.
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Remarks:
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