Discussing cystatin C @ Spring Clinical Meetings 2024

Spring Clinical Meetings (SCM) is a great occasion for renal health care providers to get insights to development in the field of nephrology. This year the meeting will be in Long Beach, CaliforniaMay 14-18^th.

We're excited to attend the event, and you will find us atbooth #744eager to talk about cystatin C, the new KDIGO guidelines and kidney health. Don't miss this chance to learn more about one of this year's most talked-about diagnostic tools in the kidney care space.

Cystatin C measuring GFR - a fast and reliable estimation of renal function

The glomerular filtration rate (GFR) is used to diagnose chronic kidney disease (CKD) and cystatin C is an established marker for estimating glomerular filtration rate (GFR). Recently the scientific community has demonstrated that measuring both creatinine and cystatin C gives a significant advantage when estimating the eGFR. One advantage of measuring cystatin C in addition to creatinine is the increased accuracy achieved partially due to cystatin C being less susceptible to factors that affect muscle mass like age, diet, sex, physical activity, etc.^1-8

Kidney health advocates and organizations embrace the benefits of cystatin C

KDIGO Guidelines

The international organization KDIGO (Kidney Disease: Improving Global Outcomes), has recently published the 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (CKD).This updated guideline places greater emphasis on the biomarker cystatin C for estimating glomerular filtration rate (GFR).

Highlighting the significance of employing the most precise GFR assessment available, the guideline underscores the utility of utilizing a combination of cystatin C and creatinine. This synergistic approach offers advantages in the management of kidney disease. Cystatin C stands out due to its independence by factors such as race and diet, and it is less susceptible to variations due to age, muscle mass, and sex.

National Kidney Foundation(NKF) and the American Society of Nephrology Task Force

The heightened interest in eGFR equationshas its origin from the movement among US medical students that questioned the use of a race coefficient in the calculation of eGFR, and the impact its use can have in healthcare disparities faced by African Americans.

As an answer to the movement a joint task force with the National Kidney Foundation(NKF) and the American Society of Nephrologywas established to reassess the inclusion of race in diagnosing kidney disease. Based on input collected over 10 months from hundreds of patients, patient advocates, medical students, clinicians and scientists, ­­the task force recommends "increased use of cystatin C combined with serum creatinine, as a confirmatory assessment of GFR or kidney function."

The European Kidney Function Consortium (EKFC) and the Chronic Kidney Disease Epidemiology Collaboration (CKD-Epi) initiative

The European Kidney Function Consortium (EKFC) has also followed up on the initiative from the Chronic Kidney Disease Epidemiology Collaboration (CKD-Epi), addressing the race factor in eGFR equations, in a recent study with data from over 227 000 patients. Their newly developed cystatin C based eGFR equation does not rely on factors for race and gender and can estimate the GFR without compromising on accuracy versus creatinine equations.

Gentian Cystatin C Immunoassay - available on most automated clinical chemistry platforms

Gentian's cystatin C immunoassay is applied to turbidimetry-based clinical chemistry platforms. It is an open channel assay, meaning it can be added to all clinical chemistry analysers.

• FDA 510(k) cleared since 2008
• CE-marked and IVDR-certified
• Developed and manufactured by Gentian
• Avian antibodies - gives less interference⁹
• Manufactured in Norway and according to ISO 13485:2016
  
  

Get in touch for more information on cystatin C

Explore cystatin C in your lab or clinical practice - fill out the form below or send an email to [email protected] for more information about the product and prices.

References:

1. Flodin M et al. Evaluation of Gentian cystatin C reagent on Abbott Ci8200 and calculation of glomerular filtration rate expressed in mL/min/1.73 m(2) from the cystatin C values in mg/L. Scand J Clin Lab Invest. 2007;67(5):560-567
2. Delgado C et al. A Unifying Approach for GFR Estimation: Recommendations of the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease. Am J Kidney Dis. 2022;79(2):268-288
3. KDIGO - CKD Evaluation and Management - 2024 Guidelines. 2024
4. Tangri N et al. Changes in dietary protein intake has no effect on serum cystatin C levels independent of the glomerular filtration rate. Kidney Int. 2011;79(4):471-477
5. Grubb A. Cystatin C is Indispensable for Evaluation of Kidney Disease. EJIFCC. 2017;28(4):268-276
6. Björk J et al. Validation of standardized creatinine and cystatin C GFR estimating equations in a large multicentre European cohort of children. Pediatr Nephrol. 2019;34(6):1087-1098
7. Inker LA et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012;367(1):20-29
8. Schaeffner E et al. Two novel equations to estimate kidney function in persons aged 70 years or older. Ann Intern Med. 2012;157(7):471-481
9. Larsson A, Sjöquist J. Chicken antibodies: a tool to avoid false positive results by rheumatoid factor in latex fixation tests. J Immunol Methods. 1988;108(1-2):205-208

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